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		题名	作者	年代	出处	被引量
	1	Distribution of linear alkylbenzenes (LABs) in riverine and coastal environments in South and Southeast Asia显示文摘	Kei O Isobea Mohamad P Zakariab Nguyen H Chiem	2004	Water Research2004，38，：	1
	2	Lignin Depolymerization with Phenol via Redistribution Mechanism in Ionic Liquids 显示文摘	Sepa N Antonio F P Kei S	2014	AmerieaJ1 Chemical Society2014，，2：	1
	3	Altered upper airway and soft tissue structures in the new zealand obese mouse显示文摘	Michael J B Allan I P Kei K	2009	Am J Respir Crit Care Med2009，179，2：	1
	4	The attenuated sopBmutant of Salmonella enterica serovar Typhimurium has the same tis-sue distribution and host chemokine response as the wild type in bo-vine Peyer’ s patches显示文摘	KEIS B P ZHANG S P TSOUS R M	2003	Vet Microbiol2003，97，34：	1
	5	Multi pie-locus Variable-nu mber tandem repeat analysis reveals genetic relationships Within Bacill us anthraeis显示文摘	Kei m P Price LB KleVytska AM	2000	J Baeteriol2000，182，10：	1
	6	Advantages of flame retardants based on nitrogen compounds显示文摘	Yang T P Pearce Kei T K	1989	Macromolecule1989，，22：	1
	7	Effects of small amount addition of rare earth Er on micro- structure and property of SnAgCu solder 显示文摘	Shi Y W Tian J Hao H Xia Z D kei Y P Guo F	2008	Journal of Al- loys and Compounds2008，453，12：	1
	8	Effect of excess aluminium and manganese on Norway spruce seedlings as related to magnesium nutrition显示文摘	BUCHHOLZ C H JORNS C A KEI P	1987	Journal of Plant Nutrition1987，10，916：	1
	9	HM30181A,a potent P-glycoprotein inhibitor,potentiates the absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumor model显示文摘Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma,owing to the presence of the blood-brain barrier and the activity of P-gp,which pumps its substrate back into the systemic circulation.The aim of the present study was to develop an intravenous formulation of HM30181 A(HM)to inhibit P-gp in the brain to effectively deliver paclitaxel(PTX)for the treatment of malignant glioma.Methods:Two formulations of solubilized HM were designed on the basis of different solid dispersion strategies:i)spray-drying[polyvinlypyrrolidone(PVP)-HM]and ii)solvent evaporation[HP-β-cyclodextrin(cyclodextrin)-HM].The P-gp inhibition of these 2 formulations was assessed on the basis of rhodamine 123 uptake in cancer cells.Blood and brain pharmacokinetic parameters were also determined,and the antitumor effect of cyclodextrin-HM with PTX was evaluated in an orthotopic glioma xenograft mouse model.Results:Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro,cyclodextrin-HM had a higher maximum tolerated dose in mice than did PVP-HM.Pharmacokinetic study of cyclodextrin-HM revealed a plasma concentration plateau at 20 mg/kg,and the mice began to lose weight at doses above this level.Cyclodextrin-HM(10 mg/kg)administered with PTX at 10 mg/kg showed optimal antitumor activity in a mouse model,according to both tumor volume measurement and survival time(P<0.05).Conclusions:In a mouse orthotopic brain tumor model,the intravenous co-administration of cyclodextrin-HM with PTX showed potent antitumor effects and therefore may have potential for glioma therapy in humans.	Wu Zeng Betty Yuen Kwan Law Vincent Kam Wai Wong Denise So Bik Chan Simon Wing Fai Mok Joyce Jia Ying Gao Rebecca Ka Yan Ho Xu Liang Jia Hao Li Ming Tsung Lee Weng Li Yoon Michael P Smolinski Johnson Yiu Nam Lau Christopher Wai Kei Lam Manson Fok	2020	Cancer Biology & Medicine2020，17，4：	0

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