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| 1 | Clinical outcome in patients with hilar malignant strictures type Ⅱ Bismuth-Corlette treated by minimally invasive unilateral versus bilateral endoscopic biliary drainage显示文摘BACKGROUND:Stenting of malignant hilar strictures remains a standard endoscopic treatment in patients with unresectable tumors.The aim of this two-center prospective study was to compare unilateral versus bilateral drainage in hilar malignant stenosis Bismuth-Corlette type II.METHODS:During a 3-year period,a total of 49 patients with hilar tumors(Bismuth-Corlette type II) were referred for endoscopic treatment,following the criteria of unresectability.Ultrasound,computed tomography scan and magnetic resonance cholangiopancreatography(MRCP) were previously performed in all patients in order to facilitate endoscopic retrograde cholangiopancreatography(ERCP).The stricture was first passed by the hydrophilic guide-wire and then contrast medium was injected.Mechanical bile duct dilation was performed,followed by plastic stent placement only in the liver lobe which was previously opacified.The procedures were performed under conscious sedation.The patients were followed up for the next 12 months with a stent exchange every 3 months.Primary outcome was assessed by patient survival in the first 12 months after the procedure.RESULTS:All 49 patients were treated with ERCP while 39(79.59%) had successful stent placement.Among these,32 had hilar cholangiocarcinoma(82%) and 7(18%) had gallbladder cancer.Two groups of patients had Bismuth II strictures:A,21 patients(54%) with unilateral contrast injection and drainage,and B,18(46%) with bilateral contrast injection and drainage.A total of 57 plastic stents were used(10 Fr,89%;11.5 Fr,11%).Group B showed a lower bilirubin level 7 days after the procedure(P=0.008).Early complications were cholangitis(3 patients,2 in group A and 1 in group B) and acute pancreatitis(2 patients,1 each in A and B) with no statistical difference between the groups.Late complications were stent migration(5 patients,1 in A and 4 in B) and stent clogging(6 patients,2 in A and 4 in B) showing a significant difference between the groups(P<0.01).The first stent replacement after 3 months was successful in 87% of patients(four died due to disease progression and one due to cardiopulmonary insufficiency) showing no statistical difference between the groups.At 6 months follow-up,72% patients survived,with no statistical difference between the groups.A final follow-up(12 months) showed the survival rate of 18%(4 patients from group A and 3 from group B)(P>0.05).CONCLUSIONS:A minimally invasive approach,based on the criterion that every bile duct being opacified needs to be drained,is associated with a lower incidence of early complications.Considering that the clinical outcome measured by bilirubin level was lower in patients with bilateral drainage 7 days after the procedure,we assumed that drainage of 50% or more of the liver volume leads to sufficient drainage effectiveness. | Milutin Bulajic Nikola Panic Miodrag Radunovic Radisav Scepanovic Radoslav Perunovic Predrag Stevanovic Tatjana Ille Maurizio Zilli Mirko Bulajic | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 8 |
| 2 | Helicobacter pylori and pancreatic diseases显示文摘A possible role for Helicobacter pylori(H. pylori) infec-tion in pancreatic diseases remains controversial. H. pylori infection with antral predomination leading to an increase in pancreatic bicarbonate output and induc-ing ductal epithelial cell proliferation could contribute to the development of pancreatic cancer via complex interactions with the ABO genotype, dietary and smok-ing habits and N-nitrosamine exposure of the host. Although the individual study data available so far is inconsistent, several meta-analyses have reported an increased risk for pancreatic cancer among H. pylori seropositive individuals. It has been suggested that H. pylori causes autoimmune pancreatitis due to molecu-lar mimicry between H. pylori a-carbonic anhydrase(a-CA) and human CA type Ⅱ, and between H. pylori plasminogen-binding protein and human ubiquitin-protein ligase E3 component n-recognin 2, enzymes that are highly expressed in the pancreatic ductal andacinar cells, respectively. Future studies involving large numbers of cases are needed in order to examine the role of H. pylori in autoimmune pancreatitis more fully. Considering the worldwide pancreatic cancer burden, as well as the association between autoimmune pan-creatitis and other autoimmune conditions, a complete elucidation of the role played by H. pylori in the gen-esis of such conditions could have a substantial impact on healthcare. | Milutin Bulajic Nikola Panic Johannes Matthias Lohr | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 3 |
| 3 | Chronic alcoholics knowledge regarding tuber-culosis显示文摘 | Panic E Panic I | 2001 | Pneumologia2001，50，4： | 1 |
| 4 | RuO2-TiO2 coated titanium anodes obtained by the sol-gel procedure and their electro- chemical behavior in the chlorine evolution reaction 显示文摘 | PANIC V V DEKANSKI A MILONJIC S K | 1999 | Colloids and Surfaces A: Physicochemieal and Engineering Aspects1999，157，13： | 1 |
| 5 | RuO2- TiO2 coated titanium anodes obtained by the sol-gel procedure and their electrochemical behaviour in the chlorine evolution re action显示文摘 | PANIC V V DEKANSKI A MILONJI C S K | 1999 | Colloids and Surfaces A: Physicochemieal and Engineering Aspects1999，157，： | 1 |
| 6 | Quality of quarg pro- dueod by probioties application显示文摘 | MILANOVIC S D PANIC M D CARIC M D | 2004 | Aeta Period Teehnol2004，35，： | 1 |
| 7 | Evaluation of the endorsement of the preferred reporting items fur systematic reviews and meta-analysis ( PRIS- MA) statement on the quality of published systematic review and meta-analy- ses显示文摘 | Panic N Leoneini E de Belvis G | 2013 | PLuS One2013，8，83： | 1 |
| 8 | Meckel's diverticulum in children: a 20-year review 显示文摘 | Stvil D Brandt ML Panic S | 1991 | J Pediatr Surg1991，26，11： | 1 |
| 9 | The properties of carbon supported hydrous ruthenium oxide obtained from RuOxHy sol显示文摘 | V PANIC T VIDAKOVIC GOJKOVIC S S | 2003 | Electrochimica Acta2003，，48： | 1 |
| 10 | Electrocatalytic activity of sol-gel-prepared RuO2/Ti anode in chlorine and oxygen evolution reactions 显示文摘 | PANIC V DEKANSKI A MILONJIC S | 2006 | Russ J Electrochem2006，42，10： | 1 |
| 11 | Docetaxel and zoledronic acid in patients with metastatic hormone-refractory prostate cancer 显示文摘 | Vordos D Panic B Vacherot F | 2004 | BJU Int2004，94，4： | 1 |
| 12 | Morphology of RuO2-TiO2 coatings and TEM characterization of oxide sols used for their preparation 显示文摘 | PANIC V DEKANSKI A WANG G | 2003 | Journal of Colloid and Interface Science2003，263，： | 1 |
| 13 | Meckel's diverticulum in children:a 20-year reviw显示文摘 | Stvil D Brandt ML Panic S | 1991 | J Pediatr Surg1991，26，11： | 1 |
| 14 | On the deactivation mechanism of RuO2-TiO2/Ti anodes prepared by the sol-gel procedure 显示文摘 | Panic V Dekanski A Miskovib-Stankovi6 V | 2005 | Journal of Eleetroanalytical Chemistry2005，579，1： | 1 |
| 15 | Effect of proprioeeption training on knee joint position sense in female team handball players显示文摘 | Panics G Tallay A Pavlik A | 2008 | Br J Sports Med2008，42，6： | 1 |
| 16 | Evaluation of the endorsement of the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement on the quality of published systematic review and meta-analyses显示文摘 | Panic N Leoncini E de Belvis G | 2013 | PLoS One2013，8，83： | 1 |
| 17 | The properties of electroactive ruthenium oxide coatings supported by titanium- based ternary carbides 显示文摘 | Panic V V Jovanovic V M Terzio S | 2007 | Surface & Coatings Technology2007，202，2： | 1 |
| 18 | Antitumor immunity after vaccination with B lymphoma cells overexpressing a triad of costimulatory molecules 显示文摘 | BRIONES J TIMMERMAN J M PANICALLI D L | 2003 | J Natl Cancer Inst2003，95，7： | 1 |
| 19 | Morphology of RuO2-TiO2 coatings and TEM characterization of oxide sols used for their preparation 显示文摘 | Panic V Dekanski A Wang G | 2003 | Journal of Colloid and Interface Science2003，263，： | 1 |
| 20 | Morphology of RuO2-TiO2 coatings and TEM characterization of oxide sols used for their preparation 显示文摘 | Panic V Dekanski A Wang G | 2003 | Journal of Colloid and Interface Science2003，263，： | 1 |
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