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| 1 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 2 | Sonographic hepatorenal ratio: A noninvasive method to diagnose nonalcoholic steatosis显示文摘 | Valéria Ferreira de Almeida e Borges Angélica L. D. Diniz Helma P. Cotrim Haroldo L. O. G. Rocha Nestor Barbosa Andrade | 2012 | J Clin Ultrasound2012，，1： | 2 |
| 3 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 4 | New approached for improving engraftment after cord blood transplanta- tion显示文摘 | ROCHA V BROXMEYER H E | 2010 | Bio Blood Marrow Transplant2010，16，： | 1 |
| 5 | Flypaper effect Revisted: Evidence for Tax Collection Efficiency in Brazilian Municipalities 显示文摘 | Mattos E Fabiana Rocha Paulo Arvate | 2011 | Estudos Econ? micos2011，41，2： | 1 |
| 6 | Probiotic potential of Mi-nas fresh cheese prepared with the addition of Lactobacillus paracasei显示文摘 | Buriti F A da Rocha J S Assis E G | | 0，，02： | 1 |
| 7 | 查看详情显示文摘 | Aleman E A Manriquez Rocha J Wongwitwichote W | | 0，，24： | 1 |
| 8 | Qualis 2011-2013- The three Rs 显示文摘 | Mauricio Rocha e Silva | 2011 | J Vasc Bras2011，10，2： | 1 |
| 9 | Probiotic potential of Minas fresh cheese prepared with the addition of Lactobacillus paracasei 显示文摘 | BURITI F C A DA ROCHA J S ASSIS E G | 2005 | Lebensmittel-Wissenschaft und Tehonlogie2005，38，2： | 1 |
| 10 | Acute generalized, widespread bleeding, diagnosis and management显示文摘 | ROCHA E PARAMO J A MONTES R | 1998 | Haematologica1998，83，： | 1 |
| 11 | Outcome of cord-blood t ransplantation from related and unrelated donors显示文摘 | Gluekman E Rocha V Boyer-Chamrnanl A | 1997 | N Engl J Med1997，337，6： | 1 |
| 12 | Codon usage and lateral gene transfer in Bacillus subtilis显示文摘 | Moszer Rocha E P C Danchin A | 1999 | Currenl O pinion in Microbiology1999，2，5： | 1 |
| 13 | Hemostasis in liver disease显示文摘 | Paramo JA Rocha E | 1993 | Semin Thromb Hemost1993，19，3： | 1 |
| 14 | Speciation of mercury using capillary electrophoresis coupled to volatile species generation-inductively coupled plasma mass spectrometry 显示文摘 | ROCHA M S SOLDADO A B BLANCO E | 2001 | J Anal At Spectom2001，，16： | 1 |
| 15 | Preoperative iden- tification of patients at high risk of deep venous thrombosis despite prophylaxis in total hip replacement显示文摘 | ROCHA E ALFARO M J PARAMO J A | 2008 | Thromb Haemost2008，59，： | 1 |
| 16 | Does gum chewing ameliorate Postoperative ileus? Results of a prospective, ran- domized, placebo controlled trial显示文摘 | Matros E Rocha F Zinner M | 2006 | J Am Coil Surg2006，202，5： | 1 |
| 17 | Acute and Chronic Effects of Atrazine and Sodium Dodecyl Sulfate on the Tropical Freshwater Cladoceran Pseudosida ramosa 显示文摘 | FREITAS E C ROCHA O | 2012 | Ecotoxicology2012，21，5： | 1 |
| 18 | Singular value decomposition and principal component analysis显示文摘 | WALL M E RECHTSTEINER A ROCHA L M | 2002 | A Practical Approach to Microarray Data Analysis2002，，5： | 1 |
| 19 | Identification and organ expression of peroxisome proliferator activated receptors in brown trout (Salmo trutta fario )显示文摘 | Batista-Pinto C Rodrigues P Rocha E | 2005 | Biochim Biophys Acta2005，1731，： | 1 |
| 20 | Psychosocial risk factors in coronary heart disease:beyond type A behavior显示文摘 | Trigo M Silva D Rocha E | 2005 | Rev Port Cardiol2005，24，2： | 1 |
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