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| 1 | Menopause and cognitive impairment:A narrative review of current knowledge显示文摘A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition. | Délio Marques Conde Roberto Carmignani Verdade Ana L R Valadares Lucas F B Mella Adriana OrcesiPedro Lucia Costa-Paiva | 2021 | World Journal of Psychiatry2021，11，8： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Specific genetic markers for wheat, spelt, and four wild relatives: Comparison of isozymes, RAPDs, and wheat microsatellites显示文摘 | Roberto G Dessislava S B Francois F | 2001 | Genome2001，44，4： | 1 |
| 4 | R&R blends as refrigerants显示文摘 | Sergio B Roberto C Laura F | 2004 | International Refrigeration and Air Conditioning Conference2004，，： | 1 |
| 5 | Late recurrent capsular hematoma afteraugmentationmammaplasty:casereport 显示文摘 | Mauro S Euqenio F Roberto B | 2005 | Aesthetic Plast Surg2005，29，1： | 1 |
| 6 | Assessment of nutritional status in free living elderly individuals by bioelectrical impedance vector analysis 显示文摘 | Roberto B 6iovanni F Elisabetta M | 2009 | btrition2009，25，： | 1 |
| 7 | 查看详情显示文摘 | María L G P Patricia P B Roberto R G José L M V Antonia G F | | 0，，27： | 1 |
| 8 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 9 | Ionic profile of honey as a potential indicator of botanical origin and global environmental pollution显示文摘 | Paola F Gianggiacomo B Roberto M F | 2013 | Environmental pollution2013，178，： | 1 |
| 10 | The Prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe: The Euro Heart Survey on diabetes and the heart显示文摘 | Malgorzata B Lars R Roberto F | 2004 | Eur Heart J2004，25，： | 1 |
| 11 | Comparative genomic analysis of hyperthermophilic archaeal Fuselloviridae viruses显示文摘 | WIEDENHEFT B STRDMAN K ROBERTO F | 2004 | J Vorol2004，78，： | 1 |
| 12 | Cloning and characterization of a wheat vacuolar cation/proton antiporter and pyrophosphatase proton pump 显示文摘 | Brini F Roberto A G Gerald A B etal | 2005 | Plant Physiology and Biochemistry2005，43，： | 1 |
| 13 | TBD-catalysed solventless synthesis of symmetrically N,N' substituted ureas from primary amines and diethyl carbonate显示文摘 | Roberto B Dennis F Raimondo M | 2003 | Green Chemistry2003，5，： | 1 |
| 14 | Assessmentof nutritional status in free-living elderlyindividuals by bioelectrical impedance vector analysis显示文摘 | Roberto B Giovanni F Elisabetta M | 2009 | Nutrition2009，25，1： | 1 |
| 15 | The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe显示文摘 | Malgorzata B Lars R Roberto F | 2004 | Eur Heart J2004，25，： | 1 |
| 16 | Curcumin,an antioxidant and anti-inflammatory agent,induces heme oxygenase-1 and protects endothelial cells against oxidative stress显示文摘 | ROBERTO M ROBERTA F REKHA B C | 2000 | Free Rad Bio Med2000，28，8： | 1 |
| 17 | Freeze Drying of Pharmaceutical Excipients close to collapse temperature: Influence of the process conditions on process time and product quality, Drying Technology 显示文摘 | Antonello A B G Sabrina F Davide P Roberto | 2009 | (27): 805-8162009，，27： | 1 |
| 18 | Human natural killer cell activating receptors 显示文摘 | Roberto B Claudia C Michela F | 2000 | Mol Immunol2000，37，3： | 1 |
| 19 | Glottal source biometricalsignature for voice pathology detection显示文摘 | PEDRO G V ROBERTO F B VICTORIA R B VICTOR N L AGUSTIN A M LUIS M M F RAFAEL M O JUAN I G L | 2009 | Speech Communication2009，51，9： | 1 |
| 20 | Self-assembly,spectroscopic,and electrochemical properties of rotaxane显示文摘 | Stoddart J F Roberto B Vincenzo B | 1996 | J Am Chem Soc1996，118，21： | 1 |
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