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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma显示文摘AIM To assess the safety and efficacy of transarterial chemoembolization(TACE) of hepatocellular carcinoma(HCC) using a new generation of 40 μm drug eluting beads in patients not eligible for curative treatment.METHODS Drug eluting bead TACE(DEB-TACE) using a new generation of microspheres(embozene tandem,40 μm) preloaded with 100 mg of doxorubicin was performed on 48 early or intermediate HCC patients with compensatedcirrhosis.Response to therapy was assessed with Response Evaluation Criteria in Solid Tumors(RECIST) and modified RECIST(m RECIST) guidelines applied to computed tomography or magnetic resonance imaging.Eleven out of the 48 treated patients treated progressed on to receive liver orthotopic transplantation(OLT).This allowed for histological analysis on the treated explanted nodules.RESULTS DEB-TACE with 40 μm showed a good safety profile without major complications or 30-d mortality.The objective response rate of treated tumors was 72.6% and 26.7% according to m RECIST and RECIST respectively.Histological examination in 11 patients assigned to OLT showed a necrosis degree > 90% in 78.6% of cases.The overall time to progression was 13 mo(11-21).CONCLUSION DEB-TACE with 40 μm particles is an effective treatment for the treatment of HCC in early-intermediate patients(Barcelona Clinic Liver Cancer stage A/B) with a good safety profile and good results in term of objective response rate and necrosis. | Giorgio Greco Tommaso Cascella Antonio Facciorusso Roberto Nani Rodolfo Lanocita Carlo Morosi Marta Vaiani Giuseppina Calareso Francesca G Greco Antonio Ragnanese Marco A Bongini Alfonso V Marchianò Vincenzo Mazzaferro Carlo Spreafico | 2017 | World Journal of Radiology2017，9，5： | 3 |
| 3 | Heterogeneous catalysis in the Fenton-type system reactive black 5/H2O2 显示文摘 | Yolanda F Roberto F Alberto A G | 2008 | Journal of Molecular Catalysis A: Chemical2008，281，12： | 1 |
| 4 | A method for calibration and validation subset partitioning显示文摘 | ROBERTO K H G MARIO C U A GLEDSON E J | 2005 | Talanta2005，67，4： | 1 |
| 5 | Berlinck显示文摘 | HERN(A)NDEZA I L C MACEDOA M L ROBERTO G S | 2004 | J Braz Chem Soc2004，15，3： | 1 |
| 6 | Residential Mortgage Default显示文摘 | Quercia Roberto G Michael A Stegman | 1992 | ournal of Housing Research1992，，3： | 1 |
| 7 | Design of a multiband OFDM system for realistic UWB channel environments显示文摘 | BATRA A BALAKRISHNAN J ROBERTO A G | 2004 | IEEE Transactions On Microwave Theory And Techniques2004，52，9： | 1 |
| 8 | Adaptation of the van Genuchten expression to the effects of empera- ture and density for compacted bentonites 显示文摘 | JACINTO A C VILLAR M V ROBERTO G E | 2009 | Applied Clay Science2009，42，34： | 1 |
| 9 | 查看详情显示文摘 | María L G P Patricia P B Roberto R G José L M V Antonia G F | | 0，，27： | 1 |
| 10 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 11 | The successive projections algorithm for spectral variable selection in classification problems 显示文摘 | Marcio J C P Roberto K H G Mario C U A | 2005 | Chemometrics and Intelligent Laboratory Systems2005，78，： | 1 |
| 12 | Cloning and characterization of a wheat vacuolar cation/proton antiporter and pyrophosphatase proton pump 显示文摘 | Brini F Roberto A G Gerald A B etal | 2005 | Plant Physiology and Biochemistry2005，43，： | 1 |
| 13 | Dynamic friction model based tire road friction estimation and emer- gency control显示文摘 | Huis A Yi J G Roberto H | 2005 | Transactions of the ASME2005，，127： | 1 |
| 14 | Batch xylitol production by Candida guilliermondii FTI20037from sugarcane bagasse hemicellulosic hydrolyzate at controlled pH values显示文摘 | R C L B Rodrigues M G A Felipe I C Roberto | 2003 | Bioprocess Biosyst Eng2003，26，： | 1 |
| 15 | Restoration of skeletal muscle leptin resp-onse does not precede the ex-ercise-induced recovery of insulin-stimulated glu-cose uptake in high-fat-fed rats显示文摘 | Lan R W Roberto A G | 2011 | Integrative andComparative Physiology2011，，49： | 1 |
| 16 | Ultra-wideband wireless system显示文摘 | Roberto A Rogerson G | 2003 | IEEE Microwave Magazine2003，4，2： | 1 |
| 17 | Activity and resistance to leaching of Cu-based catalysts in the wet oxidation of phenol显示文摘 | Francesco A Roberto G Teresa T | 2003 | Applied Catalysis B:Environmental2003，45，1： | 1 |
| 18 | Bioconversion of rice straw hemicelulose hydrolysate for the production of xylitol:Effect of pH and nitrogen source显示文摘 | ROBERTO I C C SILVA S S FELIPE M G A | 1996 | Appl Biochem Biotech1996，57，1： | 1 |
| 19 | Risk of fracture in celiac disease:Gender,dietary compliance,or both?显示文摘AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture risk.METHODS:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before study entry and a cohort of 530 age-and sex-matched controls who had been diagnosed with functional gastrointestinal disorders.Data were collected through in-person interviews with an investigator.The overall assessment window for patients was 9843 patient-years (2815 patient-years after diagnosis).RESULTS:Compared with the control group,the CD cohort showed significantly higher incidence rate and risk of first peripheral fracture before diagnosis [adjusted hazard ratio (HR):1.78,95% CI:1.23-2.56,P < 0.002] and in men (HR:2.67,95% CI:1.37-5.22,P < 0.004).Fracture risk was significantly associated with the classic CD presentation with gastrointestinal symptoms (P < 0.003).In the time period after diagnosis,the risk of fractures was comparable between the CD cohort and controls in both sexes (HR:1.08,95% CI:0.55-2.10 for women;HR:1.57,95% CI:0.57-4.26 for men).CONCLUSION:CD patients have higher prevalence of fractures in the peripheral skeleton before diagnosis.This is associated with male sex and classic clinical presentation.The fracture risk was reduced after the treatment. | María Inés Pinto Sánchez Adriana Mohaidle Andrea Baistrocchi Dolores Matoso Horacio Vázquez Andrea González Roberto Mazure Evangelina Maffei Guillermina Ferrari Edgardo Smecuol Adriana Crivelli Juan Andrés de Paula Juan C Gómez Silvia Pedreira Eduardo Maurio Julio César Bai | 2011 | World Journal of Gastroenterology2011，17，25： | 1 |
| 20 | Moisture diffusivity coefficient and convective drying, mdelling of nmrta ( Ugni molinae Turcz) : influence of temperature and vacuum on drying kinetics 显示文摘 | Kong A H Zambra C E Agu~ro J E Antonio V G Roberto Lemus- Mondaca | 2012 | Food and Bioprocess Technology2012，6，4： | 1 |
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