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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Positive aspects of caregiving in schizophrenia: A review显示文摘Schizophrenia is a severe mental illness which is associated with significant consequences for both the patients and their relatives. Due to chronicity of the illness, the relatives of patients of schizophrenia have to bear the main brunt of the illness. Studies across the world have evaluated various aspects of caregiving and caregivers such as burden, coping, quality of life, social support, expressed emotions, and psychological morbidity. In general the research has looked at caregiving as a negative phenomenon, however, now it is increasingly recognised that caregiving is not only associated with negative consequences only, also experience subjective gains and satisfaction. This review focus on the conceptual issues, instruments available to assess the positive aspects of caregiving and the various correlates of positive aspects of caregiving reported in relation to schizophrenia. The positive aspect of caregiving has been variously measured as positive caregiving experience, caregiving satisfaction, caregiving gains and finding meaning through caregiving scale and positive aspects of caregiving experience. Studies suggests that caregivers of patients with schizophrenia and psychotic disorders experience caregiving gains(in the form of becoming more sensitive to persons with disabilities, clarity about their priorities in life and a greater sense of inner strength), experience good aspects of relationship with the patient, do have personal positive experiences. Some of the studies suggest that those who experience greater negative caregiving experience also do experience positive caregiving experience. | Parmanand Kulhara Natasha Kate Sandeep Grover Ritu Nehra | 2012 | World Journal of Psychiatry2012，2，3： | 10 |
| 3 | Antioxidant activity and phenol and flavonoid contents of eight medicinal plants from Western Nepal显示文摘OBJECTIVE: The purpose of this study was to evaluate the antioxidant activity, phenolic and flavonoids contents of selected medicinal plants form the Western region of Nepal.METHODS: The antioxidant activity of selected medicinal plants were determined by using 2, 2-diphenyl-1-picrylhydrazyl radical scavenging activity; total ferric ion reducing ability through spectroscopic analysis. The content of total phenols was determined using Folin-Ciocalteu reagent, whereas Aluminum chloride colorimetric method was used for flavonoid determination.RESULTS: Extracts of Syzygium Operculatus(87%),Astilbe Rivularis(83%) and Mallotus Philippnensis(88%) showed significant free radical scavenging activity with effective concentration(EC50) close to that of ascorbic acid. Syzygium Operculatus(96%),Astilbe Rivularis(97%) and Mallotus Philippnensis(97%) had potent reducing power in concentration dependent fashion. Those plant extract with higher free radical scavenging and ferric reducing effect also showed the greater content of both phenols and flavonoids, suggesting the correlation between polyphenolic content and antioxidant activity. Those plant extracts which showed better antioxidant activity assays, also demonstrated higher total phenol and flavonoid contents. These three plants showed the presence of higher amount of phenols and flavonoids.CONCLUSION: This study may provide the scientific basis for the traditional use of those plants and may provide valuable idea for further research. | Lalita Subedi Sunita Timalsena Pabitra Duwadi Ritu Thapa Anita Paudel Kalpana Parajuli | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 8 |
| 4 | Attenuation of Collagen Induced Arthritis by Centella asiatica Methanol Fraction via Modulation of Cytokines and Oxidative Stress显示文摘Objective To investigate the anti-inflammatory, antioxidant and anti-arthritic effects of Centella asiatica methanolfraction(CaM E) on collagen-induced arthritis(CIA), an animal model of rheumatoid arthritis. Methods Arthritis was induced in female wistar rats by immunization with porcine type II collagen. The CIA rats were treated orally with CaM E(50, 150, and 250 mg/kg/day) for 15 d(beginning on day 21 of the experimental period). The clinical, histological, biochemical, and immunological parameters were assessed. Results CaM E treatment(150 and 250 mg/kg) significantly attenuated the severity of CIA and reduced the synovial inflammation, cartilage erosion, and bone erosion as evident from both histological and radiographic data. The escalated plasma levels of pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-12 alongwith nitric oxide in CIA rats decreased significantly on CaM E treatment. The serum levels of type-II collagen antibody were significantly lower in rats of CaM E(150 and 250 mg/kg) treated group than those in the arthritic group. Furthermore, by inhibiting the above mediators, CaM E also contributed towards the reversal of the disturbed antioxidant levels and peroxidative damage. Conclusion Our results clearly indicate that oral administration of CaM E suppresses joint inflammation, cytokine expression as well as antioxidant imbalance, thereby contributing to an amelioration of arthritis severity in CIA rats. | Shikha Sharma Ritu Gupta Sonu Chand Thaku | 2014 | Biomedical and Environmental Sciences2014，27，12： | 6 |
| 5 | 居民健康调查资料中的缺失数据的多重估算显示文摘目的 解决居民健康调查数据中存在的数据缺失问题 ,充分利用所采集到的数据 ,得出更有效的统计推断。方法 运用建立在马尔科夫链蒙特卡罗方法基础上的多重估算技术 ,对缺失数据进行替换 ,产生多个完整的数据集 ,进行联合统计推断。结果 弥补了由于缺失数据所造成的信息损失 ,改善了统计推断的质量。结论 多重估算技术是解决社会调查资料中数据缺失问题的有效工具。 | 曹阳 Sadana Ritu Tandon Ajay | 2002 | 中国卫生统计2002，19，5： | 6 |
| 6 | 金刚纂提取物对N-亚硝基二乙胺诱导小鼠肝癌的抗肝毒性作用(英文)显示文摘目的:通过N-亚硝基二乙胺(N-nitrosodiethylamine,DENA)诱导白化小鼠肝癌,研究金刚簒水乙醇提取物抗小鼠肝毒性的作用。方法:在给予实验小鼠口服50mg/kg的DENA两周前,先予150或400mg/kg金刚簒水乙醇提取物或浓度为0.5%或1%的丁基羟基茴香醚(butylated hydroxyanisole,BHA)连续灌胃。测定各组小鼠肝脏内细胞色素(cytochrome,Cyt)P450及b5,还原型谷胱甘肽 (reduced glutathione,GSH)、谷胱甘肽转移酶(glutathione-S-transferase,GST)以及肝组织天冬氨酸氨基转移酶(aspartate aminotransaminase,AST)、丙氨酸氨基转移酶(alanine aminotransaminase,ALT)、碱性磷酸酶(alkaline phosphatase,ALP)活性及总胆固醇和蛋白质含量。结果:口服50mg/kg的DENA可显著降低CytP450、Cytb5以及GSH、GST的浓度(P<0.01),肝组织AST、ALT、ALP活性和总蛋白含量也显著降低(P<0.01),但总胆固醇含量显著增加。经150或400mg/kg金刚簒水乙醇提取物预处理14d的实验小鼠,其由DENA诱发的各项组织生化指标异常发生显著逆转(P<0.01)。结论:金刚簒水乙醇提取物可通过提高细胞抗氧化活性、减少自由基的生成来减少致癌物DENA造成的肝脏损伤。 | Veena Sharma Pracheta Janmeda Ritu Paliwal Shatruhan Sharma | 2012 | 中西医结合学报2012，10，11： | 5 |
| 7 | Antimicrobial ability and growth promoting effects of feed supplemented with probiotic bacterium isolated from gut microflora of Cirrhinus mrigala显示文摘The present studies were conducted to isolate, select, identify and characterize gut bacteria as antimicrobial and growth promoting agent for the feed of economically important fish Cirrhinus mrigala. Intestinal microflora were isolated, counted, and identified, and their in vitro antibacterial properties were determined. The results have revealed that occurrence of Gram-negative rods was around 75% and of Gram-positive rods was 25%. Among the isolates Gram-positive were maintained in nutrient agar slants at 4°C. Of these, eight strains were replica-plated on agar seeded with Aeromonas hydrophila and only one strain CM2(C. mrigala 2) exhibited antibacterial properties in vitro showing inhibition against fish pathogen by well diffusion assay. This isolated strain was identified as Bacillus cereus. This bacterium was mass cultured and incorporated in the pelleted diet(40% protein and 18 k J g–1 gross energy) of C. mrigala to investigate its effect on growth performance, digestibility, nutrient retention and activities of digestive enzymes. The results of feeding trial revealed significantly(P<0.05) high growth performance in terms of specific growth rate, growth percent gain in body weight(BD)(272.4±1.5)%, high apparent protein digestibility((79.9±0.30)%) and low food conversion ratio in the group of fishes fed on diet containing B. cereus in comparison to the fishes fed on diet without probiotics. The carcass composition also revealed high accumulation of proteins((15.28±0.15) g 100 g–1) in fishes fed on diet containing probiotics. Intestinal enzyme activities of protease, amylase and cellulase were also significantly(P<0.05) high in the group of fishes fed on diet supplemented with probiotics indicating the extracellular enzyme production by B. cereus. These results indicate that probiotics stimulate the digestion through the supply of digestive enzyme and certain essential nutrients to animals. Also significantly(P<0.05) low excretion of metabolites, i.e., ammonia excretion and phosphate production(mg kg–1 BW d–1) was observed in the fishes fed with probiotic based diets. Thus, B. cereus appears to be a promising candidate for ptobiotic applications which can enhance growth performance and nutrient retention in C. mrigala. | Anita Bhatnagar Ritu Lamba | 2015 | Journal of Integrative Agriculture2015，14，3： | 5 |
| 8 | 临床表现罕见的流行性角结膜炎1例:腺病毒角结膜上皮炎(英文)显示文摘腺病毒角结膜炎,由腺病毒血清型8,19,37引起。腺病毒结膜炎典型的体征包括耳前淋巴结病变,结膜充血水肿,结膜下出血,结膜滤泡。腺病毒角结膜炎角膜受累情况各不相同,多数患者有弥散的轻微的浅层角膜炎,局部隆起的点状上皮损害,随后形成上皮下混浊。我们报道一例罕见的腺病毒角结膜上皮炎,为临床表现特殊的流行性角结膜炎(EKC),并回顾相关特殊病例文献。患者,男,35岁,患腺病毒结膜炎,临床表现罕见,表现为角结膜上皮炎形式,这种病例文献未见报道。经过保守治疗患者痊愈。角结膜上皮炎可以是临床表现特殊的腺病毒角结膜炎。 | Sudesh Kumar Arya Badri Prasad Badhu Ritu Amatya V G Ramachandran Poonam Lavaju | 2009 | 国际眼科杂志2009，9，8： | 4 |
| 9 | Promising drug targets and associated therapeutic interventions in Parkinson's disease显示文摘Parkinson's disease(PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in PD, novel drug targets for PD, and finally, the role of some critical beneficial natural products to control the progression of PD. | Sachchida Nand Rai Payal Singh Ritu Varshney Vivek K.Chaturvedi Emanuel Vamanu M.P.Singh Brijesh Kumar Singh | 2021 | Neural Regeneration Research2021，16，9： | 4 |
| 10 | A new approach for real time object detection and tracking on high resolution and multi-camera surveillance videos using GPU显示文摘High resolution cameras and multi camera systems are being used in areas of video surveillance like security of public places, traffic monitoring, and military and satellite imaging. This leads to a demand for computational algorithms for real time processing of high resolution videos. Motion detection and background separation play a vital role in capturing the object of interest in surveillance videos, but as we move towards high resolution cameras, the time-complexity of the algorithm increases and thus fails to be a part of real time systems. Parallel architecture provides a surpass platform to work efficiently with complex algorithmic solutions. In this work, a method was proposed for identifying the moving objects perfectly in the videos using adaptive background making, motion detection and object estimation. The pre-processing part includes an adaptive block background making model and a dynamically adaptive thresholding technique to estimate the moving objects. The post processing includes a competent parallel connected component labelling algorithm to estimate perfectly the objects of interest. New parallel processing strategies are developed on each stage of the algorithm to reduce the time-complexity of the system. This algorithm has achieved a average speedup of 12.26 times for lower resolution video frames(320×240, 720×480, 1024×768) and 7.30 times for higher resolution video frames(1360×768, 1920×1080, 2560×1440) on GPU, which is superior to CPU processing. Also, this algorithm was tested by changing the number of threads in a thread block and the minimum execution time has been achieved for 16×16 thread block. And this algorithm was tested on a night sequence where the amount of light in the scene is very less and still the algorithm has given a significant speedup and accuracy in determining the object. | Mohammad Farukh Hashmi Ritu Pal Rajat Saxena Avinash G.Keskar | 2016 | Journal of Central South University2016，23，1： | 4 |
| 11 | Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC. | Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel | 2017 | World Journal of Stem Cells2017，9，9： | 4 |
| 12 | Bioautography and its scope in the field of natural product chemistry显示文摘Medicinal plants, vegetables and fruits are the sources of huge number of bioactive lead/scaffolds with therapeutic and nutraceutical importance. Bioautography is a means of target-directed isolation of active molecules on chromatogram. Organic solvents employed in chromatographic separation process can be completely removed before biological detection because these solvents cause inactivation of enzymes and/or death of living organisms. They offer a rapid and easy identification of bioactive lead/scaffolds in complex matrices of plant extracts. Bioautography is a technique to isolate hit(s)/lead(s) by employing a suitable chromatographic process followed by a biological detection system. This review critically describes the methodologies to identify antimicrobial, antioxidant, enzyme inhibitor lead/scaffolds by employing bioautography. A significant number of examples have been incorporated to authenticate the methodologies. | Saikat Dewanjee Moumita Gangopadhyay Niloy Bhattacharya Ritu Khanra Tarun K.Dua | 2015 | Journal of Pharmaceutical Analysis2015，5，2： | 3 |
| 13 | The more the messier:centrosome amplification as a novel biomarker for personalized treatment of colorectal cancers显示文摘Colon cancer is currently the third most common cancer and second most fatal cancer in the United States,resulting in approximately 600,000 deaths annually.Though colorectal cancer death rates are decreasing by about 3%every year,disease outcomes could be substantially improved with more research into the drivers of colon carcinogenesis,the determinants of aggressiveness in colorectal cancer and the identification of biomarkers that could enable choice of more optimal treatments.Colon carcinogenesis is notably a slow process that can take decades.Known factors that contribute to the development of colon cancer are mutational,epigenetic and environmental,and risk factors include age,history of polyps and family history of colon cancer.Colorectal cancers exhibit heterogeneity in their features and are often characterized by the presence of chromosomal instability,microscopic satellite instability,or CpG island methylator phenotype.In this review,we propose that centrosome amplification may be a widespread occurrence in colorectal cancers and could potently influence tumor biology.Moreover,the quantitation of this cancer-specific anomaly could offer valuable prognostic information and pave the way for further customization of treatment based on the organellar profile of patients.Patient stratification models that take into account centrosomal status could thus potentially reduce adverse side effects and result in improved outcomes for colorectal cancer patients. | Monica M.Mahathre Padmashree C.G.Rida Ritu Aneja | 2016 | The Journal of Biomedical Research2016，30，6： | 3 |
| 14 | Through a Glass Darkly: Information Technology Design, Identity Verification, and Knowledge Contribution in Online Communities显示文摘 | Meng Ma Ritu Agarwal | 2007 | Information Systems Research2007，，1： | 2 |
| 15 | Eosinophilic Esophagitis: A 10-Year Experience in 381 Children显示文摘 | Chris A. Liacouras Jonathan M. Spergel Eduardo Ruchelli Ritu Verma Maria Mascarenhas Edisio Semeao Jonathan Flick Janice Kelly Terry Brown–Whitehorn Petar Mamula Jonathan E. Markowitz | 2005 | Clinical Gastroenterology and Hepatology2005，，： | 2 |
| 16 | Colloidal lead-free Cs_(2)AgBiBr_(6)double perovskite nanocrystals:Synthesis,uniform thin-film fabrication,and application in solution-processed solar cells显示文摘Recently developed lead-free double perovskite nanocrystals(NCs)have been proposed for the possible application in solutionprocessed optoelectronic devices.However,the optoelectronic applications of double perovskite NCs have been hampered due to the structural and chemical instability in the presence of polar molecules.Here,we report a facile strategy for the synthesis and purification of Cs_(2)AgBiBr_(6)double perovskite NCs that remained stable even after washing with polar solvent.This is realized with our efficient colloidal route to synthesize Cs_(2)AgBiBr_(6)NCs that involve stable and strongly coordinated precursor such as silvertrioctyl phosphine complex together with bismuth neodecanoate,which leads to a significantly improved chemical and colloidal stability.Using layer-by-layer solid-state ligand exchange technique,a compact and crack-free thin film of Cs_(2)AgBiBr_(6)NCs were fabricated.Finally,perovskite solar cells consisting of Cs_(2)AgBiBr_(6)as an absorber layer were fabricated and tested. | Razi Ahmad Gautam Virender Nutan Dinesh Singh Govind Gupta Udit Soni Sameer Sapra Ritu Srivastava | 2021 | Nano Research2021，14，4： | 2 |
| 17 | 14 Years of Eosinophilic Esophagitis: Clinical Features and Prognosis显示文摘 | Jonathan M Spergel Terri F Brown-Whitehorn Janet L Beausoleil James Franciosi Michele Shuker Ritu Verma Chris A Liacouras | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，1： | 2 |
| 18 | Integrated Design Environment for DC/DC Converter FET Optimization显示文摘 | Ritu Sodhi | 1999 | IEEE1999，，： | 1 |
| 19 | Dexmedetomidine prolongs the effect of bupivacaine in supraclavicular brachial plexus block显示文摘 | Sandhya Agarwal Ritu Aggarwal Praveen Gupta | 2014 | Journal of Anaesthesiology Clinical Pharmacology2014，，1： | 1 |
| 20 | Neighborhood spaces in residential environments:Lessons for contemporary Indian context显示文摘The importance of open and unbuilt neighborhood spaces in residential developments has been established by numerous scholars.Having a diverse nomenclature in varied contexts,these areas are indispensable yet often neglected and designated as leftovers in contemporary planning practice.With their usefulness in the Indian context of socially active and sometimes even intrusive communities,such spaces are rapidly losing their place in present-day residential environments due to the pressure of providing for the rapidly growing population coupled with mass migratory patterns.These neighborhood spaces that impart physical,psychological,and perceptual comfort to residents have been present in spontaneously developed traditional Indian cities due to their inherent order and integrity.Moreover,some contemporary housing environments by eminent designers have also utilized the virtues of well-designed neighborhood environments.This study is a comparative analysis of three selected projects,which aspire to devise suitable methods for contemporary Indian context and achieve neighborhood comfort and an overall sense of belongingness among residents. | Ritu Gulati | 2020 | Frontiers of Architectural Research2020，9，1： | 1 |
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