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1Anatomically realistic multiscale models of normal and abnormal gastrointestinal electrical activity显示文摘One of the major aims of the International Union of Physiological Sciences (IUPS) Physiome Project is to develop multiscale mathematical and computer models that can be used to help understand human health. We present here a small facet of this broad plan that applies to the gastrointestinal system. Specifically, we present an anatomically and physiologically based modelling framework that is capable of simulating normal and pathological electrical activity within the stomach and small intestine. The continuum models used within this framework have been created using anatomical information derived from common medical imaging modalities and data from the Visible Human Project. These models explicitly incorporate the various smooth muscle layers and networks of interstitial cells of Cajal (ICC) that are known to exist within the walls of the stomach and small bowel. Electrical activity within individual ICCs and smooth muscle cells is simulated using a previously published simplified representation of the cell level electrical activity. This simulated cell level activity is incorporated into a bidomain representation of the tissue, allowing electrical activity of the entire stomach or intestine to be simulated in the anatomically derived models. This electrical modelling framework successfully replicates many of the qualitative features of the slow wave activity within the stomach and intestine and has also been used to investigate activity associated with functional uncoupling of the stomach.Leo K Cheng Rie Komuro Travis M Austin Martin L Buist Andrew J Pullan 2007World Journal of Gastroenterology2007,13,9:3
2Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre 2013Fundamental & Clinical Pharmacology2013,,4:2
3Unveiling the burden of pertussis 显示文摘Van Boven M Ferguson NM Van Rie A 2004Trends Microbiol2004,12,3:1
4Developmentof a continuous electrodialysis fermentation system for production of lactic acid by Lactobacillus rhamnosus显示文摘GAO M T MICI-HTERU K RIE G 2005Process Biochemistry2005,40,:1
5Amendment of soil with coal fly ash modified the burrowing habits of two earthworm species显示文摘Yunusa I M Braun M Law rie R 2009Applied Soil Ecolog y2009,,42:1
6Heterolayer light-emitting diodes based on new oxadiazole polymers显示文摘Meier M Buchwald E Karg S Psch P Greezmiel M Strohriegl P Rie W 1996Synthetic Metals1996,76,:1
7Bacillus thuringiensis:A common member of microflora in activated sludges of a sewage treatment plant显示文摘EIICHI M MINORU M RIE T 2001Current Microbiology2001,42,6:1
8Development of a continuous electrodialysis fermentation system for production of lactic acid by Lactobacillus rhamnosus显示文摘GAO M T MICHITERU K RIE G 2005Process Biochemistry2005,40,:1
9Duration of immunity against pertussis after natural infection or vaccination 显示文摘WENDELBOE A M VAN RIE A SALMASO S 2005Pediatr Infect Dis J2005,24,5:1
10Catalytic asymmetric synthesis of R207910显示文摘YUTAKA S RIE M SAE M 2010J Am Chem Soc2010,132,:1
11Unveiling the burden of pertussis显示文摘van Boven M Ferguson NM van Rie A 2004Trends Microbiol2004,12,3:1
12A Study on the Dispersion,Preparation,Characterization and Photo-degradation of Polypropylene Traced with Rare Earth Oxides显示文摘Feliks B Valérie M Jean B 2010Polymer Degradation and Stability2010,96,:1
13A comparative study of food habits and body shape perception of university students in Japan and Korea显示文摘 Rie A Yoshie M 2005Nutrition Journal2005,,4:1
14Simultaneous Deter- mination of Di(2-ethylhexy-1) Phthalate,Mono(2-ethylhex- yl) Phthalate,and Phthalic Acid Migrating from Gamma-ray Irradiated Polyvinyl Chloride Sheet by Liquid Chromatogra- phy-tandem Mass Spectrometry显示文摘RIE I NAOKO M MIGAKU K 2008Journal of Liquid Chro- matography & Related Technologies2008,31,:1
15Formalin-fixed paraffin embedded tissue: the holy grail of clinical proteomics显示文摘Valérie B Lise P Evelyne M 2014Proteomics Clinical Application2014,8,10:1
16Mechanism of Insect Resistance to the Microbial Insecticide Bacillus Thuringiensis 显示文摘VAN RIE J M CGAUGHEY W H JOHNSON D E 1990Science1990,,72:1
17ADAMTS10 Mutations in Autosomal Recessive Weill-Marchesani Syndrome显示文摘Nathalie Dagoneau Catherine Benoist-Lasselin Céline Huber Laurence Faivre André Mégarbané Abdulrahman Alswaid Hélène Dollfus Yves Alembik Arnold Munnich Laurence Legeai-Mallet Valérie Cormier-Daire 2004The American Journal of Human Genetics2004,,5:1
18Radiologically and histologi-cally mixed liposarcoma: a report of two biphasic cases显示文摘Rie T Hatori M Watanabe M 2003Jpn JClin0ncol2003,33,9:1
19Nutrient dynamics at the sediment-water interface in a Mediterranean lagoon ( Than, France) : Influence of biodeposition by shellfish farming activities 显示文摘VALE'RIE M SYLVIE O GABRIEL B 2007Marine Environmental Research2007,63,:1
20Resistance to the Bacillus thuringiensis bioinsecticide in a field population of Plutella xylos- tella is due to a change in a midgut membrane receptor显示文摘Ferr6 J Real M D Van Rie J 1991Pro- ceedings of the National Academy of Sciences of the United States of America1991,88,12:1
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