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| 1 | PI3K signaling pathway targeting by using different molecular approaches to treat cancer显示文摘Recent evidence of research has been proposed that the phosphoinositide 3-kinase(PI3K) pathway is noticeable target for searching novel anticancer agents. The phosphoinositide 3-kinase(PI3K) is accountable for harmonizing a diverse range of cell functions, such as transcription, proliferation, cell survival, cell growth, degranulation, vesicular trafficking and cell migration, which are mostly involved in carcinogenesis. Particularly, PI3K-mediated signaling molecules and its effects on gene expression contribute to tumorigenesis. PI3Ks generally are grouped into three distinct classes: Ⅰ, Ⅱ and Ⅲ according to their structure and function. The class IA of PI3K includes an alpha, beta or delta p110 catalytic subunit(p110α, p110β, or p110γ), which are associated with the activation of RTKs. Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, have just been recognized as novel mechanisms of inducing oncogenic PI3K signaling. Therefore, the class IA PI3K is the only one of most evidently implicated in cancer. The PI3K pathway is mostly mutated in more cancer patients compared with normal person, making it an eyecatching molecular target for analyses based on inhibitor molecule. In this article, we highlighted the signaling effects and regulation pathway of PI3K involved in the development and survival of tumor cells. The consequence and intricacy of PI3K pathway made it an essential beneficial target for cancer treatment. | Mohammad Rashid Shahid Karim Babar Ali Shamshir Khan Makhmur Ahmad Asif Husain Ravinesh Mishra | 2017 | Journal of Chinese Pharmaceutical Sciences2017，26，9： | 7 |
| 2 | Pancreatic necrosis:Complications and changing trend of treatment显示文摘Incidence of acute pancreatitis seems to be increasing in the Western countries and has been associated with significantly increased morbidity. Nearly 80% of the patients with acute pancreatitis undergo resolution; some develop complications including pancreatic necrosis. Infection of pancreatic necrosis is the leading cause of death in these patients. A significant portion of these patients needs surgical interventions. Traditionally, the 'gold standard' procedure has been the open surgical necrosectomy, which is now being completed by the relatively lesser invasive interventions. Minimally invasive surgical(MIS) procedures include endoscopic drainage, percutaneous image-guided catheter drainage, and retroperitoneal drainage. This review article discusses the open and MIS interventions for pancreatic necrosis with each having its own respective benefits and disadvantages are covered. | Mamoon Ur Rashid Ishtiaq Hussain Sundas Jehanzeb Waqas Ullah Saeed Ali Akriti Gupta Jain Neelam Khetpal Sarfraz Ahmad | 2019 | World Journal of Gastrointestinal Surgery2019，11，4： | 7 |
| 3 | Response of Wheat to Tillage Plus Rice Residue and Nitrogen Management in Rice-Wheat System显示文摘Zero tillage with residues retention and optimizing nitrogen fertilization are important strategies to improve soil quality and wheat(Triticum aestivum L.) yield in rice(Oryza sativa L.)-wheat system. Field experiments were conducted on silty clay soil(Hyperthermic, and Typic Torrifluvents) in D. I. Khan, Pakistan, to explore the impact of six tillage methods(zero tillage straw retained(ZTsr), ZT straw burnt(ZTsb), reduced tillage straw incorporated(RTsi, including tiller and rotavator), RT straw burnt(RTsb), conventional tillage straw incorporated(CTsi, including disc plow, tiller, rotavator, and leveling operations), CT straw burnt(CTsb)) and five nitrogen rates, i.e., 0, 100, 150, 200, and 250 kg ha-1 on wheat yield. Mean values for N revealed that spikes m-2, grains/spike, 1 000-grain weight(g), and grain yield(kg ha-1) were significantly higher at 200 kg N ha-1 in both the years as well as mean over years than all other treatments. Mean values for tillage revealed that ZTsr produced highest number of spikes m-2 among tillage methods. However, grains/spike, 1 000-grain weight, and grain yield were higher in tillage methods with either straw retained/incorporated than tillage methods with straw burnt. Interaction effects were significant in year 1 and in mean over years regarding spikes m-2, 1 000-grain weight, total soil organic matter(SOM), and total soil N(TSN). ZTsr produced the most spikes m-2 and 1 000-grain weight at 200 kg N ha-1. ZTsr also produced higher SOM and TSN at 200-250 kg N ha-1 at the end of 2 yr cropping. Thus ZTsr with 200 kg N ha-1 may be an optimum and sustainable approach to enhance wheat yield and soil quality in rice-wheat system. | Khalid Usman Ejaz Ahmad Khan Niamatullah Khan Abdur Rashid Fazal Yazdan Saleem Ud Din | 2014 | Journal of Integrative Agriculture2014，13，11： | 6 |
| 4 | Spatio-temporal variation of land surface temperature and temperature lapse rate over mountainous Kashmir Himalaya显示文摘In this study, Land Surface Temperature(LST) and its lapse rate over the mountainous Kashmir Himalaya was estimated using MODIS data and correlated with the observed in-situ air temperature(Tair) data. Comparison between the MODIS LST and Tair showed a close agreement with the maximum error of the estimate ±1°C and the correlation coefficient >0.90. Analysis of the LST data from 2002-2012 showed an increasing trend at all the selected locations except at a site located in the southeastern part of Kashmir valley. Using the GTOPO30 DEM, MODIS LST data was used to estimate the actual temperature lapse rate(ATLR) along various transects across Kashmir Himalaya, which showed significant variations in space and time ranging from 0.3°C to 1.2°C per 100 m altitude change. This observation is at variance with the standard temperature lapse rate(STLR) of 0.65°C used universally in most of the hydrological and other land surface models. Snowmelt Runoff Model(SRM) was used to determine the efficacy of using the ATLR for simulating the stream flows in one of the glaciated and snow-covered watersheds in Kashmir. The use of ATLR in the SRM model improved the R2 between the observed and predicted streamflows from 0.92 to 0.97.It is hoped that the operational use of satellite-derived LST and ATLR shall improve the understanding and quantification of various processes related to climate, hydrology and ecosystem in the mountainous and data-scarce Himalaya where the use of temperature and ATLR are critical parameters for understanding various land surface and climate processes. | Shakil Ahmad ROMSHOO Mohammd RAFIQ Irfan RASHID | 2018 | Journal of Mountain Science2018，15，3： | 4 |
| 5 | Composition ship collision risk based on fuzzy theory显示文摘Despite of modern navigation devices, there are problems in navigation of vessels in waterways due to the geographical structures, disturbances in water, dynamic nature, and heavily environmental influenced sea traffic. Even though all vessels are equipped with modern navigation devices, the accidents are reported caused by various reasons and mainly by human factor according to investigation. We propose an effective and efficient composition collision risk calculation method for finding the collision probability and avoiding the collision between ships in possible collision situations. The proposed composition collision risk calculation method at ship's position using combination of fuzzy and fuzzy comprehensive evaluation methods. The algorithm is straightforward to implement and is shown to be effective in automatic ship handling for ships involved in complex navigation situations. Experiments are carried out with indigenous data and the results show the effectiveness of the proposed approach. | CHEN Shu Rashid Ahmad Byung-Gil Lee Do Hyeun Kim | 2014 | Journal of Central South University2014，21，11： | 3 |
| 6 | Oxidative desulfurization of dibenzothiophene over Fe promoted Co–Mo/Al_2O_3 and Ni–Mo/Al_2O_3 catalysts using hydrogen peroxide and formic acid as oxidants显示文摘This work reports the enhancing effect of a highly cost effective and efficient metal, Fe, incorporation to Co or Ni based Mo/Al_2O_3 catalysts in the oxidative desulfurization(ODS) of dibenzothiophene(DBT) using H_2O_2 and formic acid as oxidants. The influence of operating parameters i.e. reaction time, catalyst dose, reaction temperature and oxidant amount on oxidation process was investigated. Results revealed that 99% DBT conversion was achieved at 60 °C and 150 min reaction time over Fe–Ni–Mo/Al_2O_3. Fe tremendously enhanced the ODS activity of Co or Ni based Mo/Al_2O_3 catalysts following the activity order: Fe–Ni–Mo/Al_2O_3 NFe–Co–Mo/Al_2O_3 NNi–Mo/Al_2O_3 NCo–Mo/Al_2O_3, while H_2O_2 exhibited higher oxidation activity than formic acid over all catalyst systems. Insight about the surface morphology and textural properties of fresh and spent catalysts were achieved using scanning electron microscopy(SEM), X-ray diffraction(XRD), energy dispersive X-ray(EDX)analysis, Atomic Absorption Spectroscopy(AAS) and BET surface area analysis, which helped in the interpretation of experimental data. The present study can be deemed as an effective approach on industrial level for ODS of fuel oils crediting to its high efficiency, low process/catalyst cost, safety and mild operating condition. | Yaseen Muhammad Ayesha Shoukat Ata Ur Rahman Haroon Ur Rashid Waqas Ahmad | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 3 |
| 7 | Physiological and biochemical appraisal for mulching and partial rhizosphere drying of cotton显示文摘Water is the main factor for the healthy life of plant.One of the main negative effects of climate change is the increasing scarcity of water that is lethal for plant.Globally,for water deficit regions(arid and semi-arid),drought is the main factor responsible for low production of agriculture,especially for cotton.Great efforts have been and are being made to find alternatives to water saving practices.This study aimed to examine the effects of partial rhizosphere drying(PRD,half of the root system irrigated at one event,and the other half irrigated in the next event,and so on)with and/or without various mulching treatments on physiological and biochemical traits of cotton.To explore this objective,we laid out experiments in completely randomized design with factorial arrangement in the Islamia University of Bahawalpur,Pakistan in 2016.Two factors included were four mulching treatments(M0,no mulching;M1,black plastic mulching;M2,wheat straw mulching;and M3,cotton sticks mulching)and two irrigation levels(I0,control(full irrigation);and I1,PRD).Fisher's analysis of variance among means of treatments was compared using least significant difference test at 5% probability level.Results revealed that the maximum plant height,leaf area,leaf gas exchange(photosynthetic rate and stomata conductance),chlorophyll,proline and total sugar contents,and enzyme activities were higher under M2 than under other three mulching treatments.As for irrigation levels,higher values of plant height,photosynthesis and water related parameters(leaf water potential,leaf osmotic potential,leaf turgor potential,etc.)were recorded.Contents of total sugar and proline and activities of antioxidant enzymes were significantly higher in PRD-treated plants than in control plants.It was concluded that combined application of PRD and mulching was more effective than the rest of the treatments used in the experiment.Similar study can be conducted in the field by applying irrigation water in alternate rows in semi-arid regions. | Rashid IQBAL Muhammad A S RAZA Muhammad F SALEEM Imran H KHAN Salman AHMAD Muhammad S ZAHEER Muhammad U ASLAM Imran HAIDER | 2019 | Journal of Arid Land2019，11，5： | 2 |
| 8 | Strongly correlated intermetallic rare-earth monoaurides(Ln-Au):Ab-initio study显示文摘In this paper, we explored the structural, elastic and mechanical properties of the strongly correlated electron systems, intermetallic Ln-Au(Ln = Ce, Pr, Nd, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) in cubic structure,using PF-LAPW method within the density functional theory. Structural properties of these intermetallics were investigated by treating the exchange-correlation potential with the GGA-PBE, GGA-PBEsol and GGA + U. The effectiveness of the U for the structural properties as compared to other methods confirms the strong correlated nature of these compounds and the calculated lattice constants endorse the divalency of Yb. The results demonstrate the stable cubic CsCl structure of these compounds. Bulk modulus, Young's modulus, shear modulus, B/G ratio, Cauchy pressure, Poisson's ratio, anisotropic ratio,Kleinman parameters and Lame's coefficients were studied using the PBEsol to evaluate their importance in various types of engineering applications. The most prominent features of these compounds are their ductility, very high melting points, resistance to corrosion, and anisotropic nature. | Sardar Ahmad M.Shafiq Rashid Ahmad S.Jalali-Asadabadi Iftikhar Ahmad | 2018 | Journal of Rare Earths2018，36，10： | 2 |
| 9 | Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies显示文摘Bis-thiobarbiturate derivatives 1–15 have been synthesized, characterized by1 HNMR and EI-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with IC_(50) values ranging 7.45 0.12 74.24 0.81 mmol/L while the standard thiourea behaved normally(IC_(50) = 21.10 0.12). Compounds 1(IC_(50) = 7.45 0.12 μmol/L), 9(IC_(50) = 18.17 1.03 μmol/L) and 13(IC_(50) = 8.61 0.45 μmol/L) showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme.Structure-activity relationship has also been established for these compounds. This study identified bisthiobarbiturate as a novel class of urease inhibitors. | Fazal Rahim Muhammad Ali Shifa Ullah Umer Rashid Hayat Ullah Muhammad Taha Muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid Muhammad Bilal | 2016 | Chinese Chemical Letters2016，27，5： | 2 |
| 10 | Recent Insights into Signaling Responses to Cope Drought Stress in Rice显示文摘Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies in rice include stomatal closure,cellular adaptation and changes in root development.Moreover,the endogenous plant hormones(abscisic acid and jasmonic acid)and reactive oxygen species have paramount importance in drought tolerance in rice.The drought tolerance induces modification in biochemical,molecular and physiological properties of plants.At the molecular level,expression of several transcription-factors is modulated which further determine the activation of drought responsive gene families.Mitogen activated protein kinases and Ca signaling pathways initiate an array of signaling cascade for mediating the gene expression in rice.Approaches,conventional breeding methods combined with modern emerging techniques such as genetic engineering,to improve rice drought tolerance were discussed.This review provided recent insights into major regulatory factors against drought stress,signaling mechanisms and molecular engineering strategies(including conventional transgenic and recent genome editing approaches)to induce drought tolerance in rice. | Muhammad Mahran ASLAM Muhammad Abdul Rehman RASHID Mohammad Aquil SIDDIQUI Muhammad Tahir KHAN Fozia FARHAT Shafquat YASMEEN Imtiaz Ahmad KHAN Shameem RAJA Fatima RASOOL Mahboob Ali SIAL ZHAO Yan | 2022 | Rice science2022，29，2： | 2 |
| 11 | Sinapic acid ameliorates D-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways显示文摘BACKGROUND Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer activities.Its mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue injuries.AIM To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/Dgalactosamine(D-GalN)-induced acute liver failure(ALF)in rats.METHODS Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg D-GalN in normal saline.SA was administered orally once daily starting 7 d before LPS/D-GalN treatment.RESULTS Data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MDA)and NO levels in ALF model rats.However,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling pathway.CONCLUSION In conclusion,SA offers significant protection against LPS/D-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB. | Mushtaq Ahmad Ansari Mohammad Raish Yousef A Bin Jardan Ajaz Ahmad Mudassar Shahid SheikhFayaz Ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet | 2021 | World Journal of Gastroenterology2021，27，7： | 2 |
| 12 | Structural, electronic, and optical properties of ZnO_(1-x)Se_x alloys using first-principles calculations显示文摘The structural, electronic, and optical properties of binary ZnO, ZnSe compounds, and their ternary ZnO 1-x Se x alloys are computed using the accurate full potential linearized augmented plane wave plus local orbital (FP-LAPW + lo) method in the rocksalt (B1) and zincblende (B3) crystallographic phases. The electronic band structures, fundamental energy band gaps, and densities of states for ZnO 1-x Se x are evaluated in the range 0 ≤ x ≤ 1 using Wu-Cohen (WC) generalized gradient approximation (GGA) for the exchange-correlation potential. Our calculated results of lattice parameters and bulk modulus reveal a nonlinear variation for pseudo-binary and their ternary alloys in both phases and show a considerable deviation from Vegard's law. It is observed that the predicted lattice parameter and bulk modulus are in good agreement with the available experimental and theoretical data. We establish that the composition dependence of band gap is semi-metallic in B1 phase, while a direct band gap is observed in B3 phase. The calculated density of states is described by taking into account the contribution of Zn 3d, O2p, and Se 4s, and the optical properties are studied in terms of dielectric functions, refractive index, reflectivity, and energy loss function for the B3 phase and are compared with the available experimental data. | Muhammad Rashid Fayyaz Hussain Muhammad Imran S A Ahmad N A Noor M U Sohaib S M Alay-e-Abbas | 2013 | Chinese Physics B2013，22，8： | 2 |
| 13 | Preliminary cardiovascular activity evaluation of capparidisine, a spermidine alkaloid from Capparis deciduas 显示文摘 | RASHID S LODHI F AHMAD M | 1989 | Pak J Pharmacol1989，6，12： | 1 |
| 14 | Epidemiologic aspects of postpartum pituitary hypofunction (Sheehan’s syndrome)显示文摘 | Abdul Hamid Zargar Bikram Singh Bashir Ahmad Laway Shariq Rashid Masoodi Arshad Iqbal Wani Mir Iftikhar Bashir | 2005 | Fertility and Sterility2005，，2： | 1 |
| 15 | Short Response of Spring Wheat to Tillage, Residue Management and Split Nitrogen Application in a Rice-Wheat System显示文摘A field experiment was conducted to study the impact of tillage, crop residue management and nitrogen(N) splitting on spring wheat(Triticum aestivum L.) yield over 2 yr(2010-2012) in a rice(Oryza sativa L.)-wheat system in northwestern Pakistan. The experiment was conducted as split plot arranged in randomized complete blocks design with three replications. Treatments comprised six tillage and residue managements: zero tillage straw retained(ZTsr), zero tillage straw burnt(ZTsb), reduced tillage straw incorporated(RTsi), reduced tillage straw burnt(RTsb), conventional tillage straw incorporated(CTsi), and conventional tillage straw burnt(CTsb) as main plots and N(200 kg ha-1) was applied as split form viz., control(no nitrogen & no splitting, N0S0); 2 splits of total N, half at sowing and half at the 1st irrigation(i.e., 20 d after sowing(DAS))(NS1); 3 splits of total N, 1/3 at sowing, 1/3 at the 1st irrigation, and 1/3 at the 2nd irrigation(NS2); 4 splits of total N, 1/4 at sowing, 1/4 at the 1st irrigation, 1/4 at the 2nd irrigation(45 DAS), and 1/4 at the 3rd irrigation(70 DAS)(NS3); and 4 splits of total N, 1/4 at the 1st irrigation, 1/4 at the 2nd irrigation, 1/4 at the 3rd irrigation, and 1/4 at the 4th irrigation(95DAS)(NS4) as sub plots. The results showed that the most pikes m-2, grains/spike, 1 000-grain weight, grain yield, and N use efficiency(NUE) were obtained at zero tillage, straw retained and 4 splits application of total N(i.e., at sowing 20, 45 and 70 d after sowing). The results indicated that ZTsr with application of 200 kg N ha-1 in 4 equal splits viz. at sowing 20, 45 and 70 d after sowing is an appropriate strategy that enhanced wheat yield(7 436-7 634 kg ha-1) and N efficiency(28.6-29.5 kg kg-1) in rice-wheat system. | Khalid Usman Ejaz Ahmad Khan Fazal Yazdan Niamatullah Khan Abdur Rashid Saleem Ud Din | 2014 | Journal of Integrative Agriculture2014，13，12： | 1 |
| 16 | Aspects of cationic dye molecule adsorption to palygorskite显示文摘 | Ahmed A-F Ahmad J Rashid A-H | 2007 | Desalination2007，214，： | 1 |
| 17 | Aspects of cat ionic dye molecule adsorption to palygorskite显示文摘 | Ahmed Alfutaisi Ahmad Jamrah Rashid Alhanai | 2007 | Desalination2007，214，13： | 1 |
| 18 | Factors influencing clients in the selection of offshore software out- sourcing vendors: An exploratory study using a systematic literature review 显示文摘 | SIFFAT ULLAH KHAN MAHMOOD NIAZI RASHID AHMAD | 2011 | The Journal of Systems and Software2011，，84： | 1 |
| 19 | Outcome of ventricular septal defect closure显示文摘 | Saleem K Ahmad SA Rashid A | 2004 | J Ooll Physicians Surg Pak2004，14，： | 1 |
| 20 | A review on 3D terrain visualization of GIS data:techniques and software显示文摘3D terrain visualization of geographic information systems(GIS)data has become an important issue in recent years.This is due to the emergence of new geo-browsers such as Google Earth,widely popular among users.The availability of 3D representation tools has increased the demand for 3D terrain visualization.The aim of this paper is to review the literature related to the 3D terrain visualization of GIS data from the first map produced until the online mapping era.The reviews are divided into four different sections:manual visualization of 3D terrain,automated visualization of 3D terrain,online visualization of 3D terrain,and software for visualizing 3D terrain.Then,the paper compares between the different types of systems developed by various authors based on the capabilities and the limitations of the system.Some of the techniques have their own strengths and limitations which solve the problem in 3D terrain visualization.However,the research on improving 3D terrain visualization is still ongoing.This is due to the popularity of online environments and mobile devices that render 3D terrain.This review paper will help interested users understand the current state of 3D terrain visualization of GIS data in a better way. | Che Mat RUZINOOR Abdul Rashid Mohamed SHARIFF Biswajeet PRADHAN Mahmud RODZI AHMAD Mohd Shafry Mohd RAHIM | 2012 | Geo-Spatial Information Science2012，15，2： | 1 |
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