|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | CD14,a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein显示文摘 | Wright S D Ramos R A Tobias P S | 1990 | Science1990，249，4975： | 2 |
| 4 | A study on the characteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Trans on Power Delivery1993，8，4： | 1 |
| 5 | How can symptomatic hypotension be improved in hemodialysis patients:cold dialysis vs isothemal dialysis显示文摘 | Ramos R Soto C Mestres R | 2007 | Nefrologia2007，27，： | 1 |
| 6 | Isopentenyl diphosphate isomerase and prenyltransferase activities in rubiaceous and apocynaceous cultures显示文摘 | Ramos V A C Vander H R Verpoorte R | 1998 | Phytochemistry1998，48，： | 1 |
| 7 | A study on the char- acteristics of various conductive contaminants accumulated on high voltage insulators显示文摘 | Ramos N G Campillo R M T Naito K | 1993 | IEEE Transactions on Power Deliv- ery1993，8，18： | 1 |
| 8 | Shoot and root growth cycles of avocado in South Florida 显示文摘 | Ploletz R C Ramos J L Pan'ado J L | 1991 | Florida State Horticultural Socie- ty1991，，104： | 1 |
| 9 | Tenascin and β6 integrin are overexpressed in floor of mouth in situ carcinomas and invasive squamous cell carcinomas显示文摘 | Regezi JA Ramos DM Pytela R Dekker NP Jordan RCK | | 0，，04： | 1 |
| 10 | Variability of subjective classifications of comeal topography maps from LASIK candidates 显示文摘 | Ramos IC Correa R Guerra FP | 2013 | J Refract Surg2013，29，11： | 1 |
| 11 | Characterization of traditional and exotic apple varieties from Portugal part 1-nutritional, phytochemical and sensory evaluation显示文摘 | FELICIANO R P ANTUNES C RAMOS A | 2010 | Journal of Functional Foods2010，2，1： | 1 |
| 12 | Interfacial and colloidal behavior of asphaltenes obtained from Brazilian crude oils 显示文摘 | Antonio Carlos Da Silva Ramos Lilian Haraguchi Fabio R Notrispe | 2001 | Journal of Petroleum Science and Engineering2001，32，： | 1 |
| 13 | Sperm DNA fragmentation in infertile men with genitourinary infection by Chlamydia trachomatis and Mycoplasma显示文摘 | Gallegos G Ramos B Santiso R | 2008 | Fertil Steril2008，90，2： | 1 |
| 14 | Role of cortical cell type and morphology in sub- and su- prathreshold uniform electric field stimulation in vitro 显示文摘 | Radman T Ramos R L Brumberg J C | 2009 | Brain Stimulation2009，2，4： | 1 |
| 15 | Further insights into the Ru nanoparticles carbon interactions and their role in the catalytic properties 显示文摘 | Alarc6n M C Valiente A M Ramos I R | 2005 | Carbon2005，43，13： | 1 |
| 16 | Practical stability of switched systems without a common equilibria and governed by a time-dependent switching signal显示文摘 | KUIAVA R RAMOS R A POTA H R | 2013 | European Journal of Control2013，19，3： | 1 |
| 17 | Quantifi- cation of eccrine sweat glands with acetylcholine sweat-spot test and anatomical redistribution of sweating after T2-T3 thoracoseopie sympathieol- ysis显示文摘 | Ramos R Masuet C Badia M | 2009 | Surg Endosc2009，23，： | 1 |
| 18 | Effects of allelopathic compounds of compollen on respiration and cell dibision of watermelon显示文摘 | Ortega R C Anaya A L Ramos A L | 1988 | J Chem Ecol1988，，： | 1 |
| 19 | Human lung myofibroblastderived inducers of alveolar epithelial apoptosis identified as angiotensin peptides 显示文摘 | Wang R Ramos C Joshi I | 1999 | Am J Pathol1999，277，6： | 1 |
| 20 | Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotension peptides显示文摘 | Wang R Ramos C Joshi I | 1999 | Am J Physiol1999，277，61： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员