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| 1 | Inflammation and immunosuppression in severe acute pancreatitis显示文摘Acute pancreatitis(AP) is a common disease,which usually exists in its mild form.However,in a fifth of cases,the disease is severe,with local pancreatic complications or systemic organ dysfunction or both.Because the development of organ failure is the major cause of death in AP,early identification of patients likely to develop organ failure is important.AP is initiated by intracellular activation of pancreatic proenzymes and autodigestion of the pancreas.Destruction of the pancreatic parenchyma first induces an inflammatory reaction locally,but may lead to overwhelming systemic production of inflammatory mediators and early organ failure.Concomitantly,anti-inflammatory cytokines and specific cytokine inhibitors are produced.This anti-inflammatory reaction may overcompensate and inhibit the immune response,rendering the host at risk of systemic infection.At present,there is no specific treatment for AP.Increased understanding of the pathogenesis of systemic inflammation and development of organ dysfunction may provide us with drugs to ameliorate physiological disturbances. | Marja-Leena Kylnp Heikki Repo Pauli Antero Puolakkainen | 2010 | World Journal of Gastroenterology2010，16，23： | 97 |
| 2 | Dasatinib用于治疗对伊马替尼耐药的Ph染色体阳性白血病显示文摘 | Talpaz M Shah NP Kantarjian H 菅鑫妍 | 2006 | 中国处方药2006，5，8： | 12 |
| 3 | 关于全球冷暖和亚、非夏季风区干湿变迁之联系的一个述评显示文摘基于近年来的多种资料分析结果,讨论了不同时间尺度上全球热状况之于中国东部和其它低纬亚非夏季风影响区干湿变迁的宏观控制作用。指出:在百年以上时间尺度上,全球暖而夏季风强从而导致有关区域多雨偏湿,全球冷则夏季风区域多偏干;但较短时间尺度上的全球性冷暖波动往往不足以使各地的夏季风系统和干湿状况产生一致响应。 | 严中伟 Maire,NP | 1995 | 地理学报1995，50，5： | 11 |
| 4 | 同型半胱氨酸增强血白细胞粘附分子的表达显示文摘用免疫萤光流式细胞仪检测同型半胱氨酸是否改变体外健康人血单核细胞 ,中性粒细胞 ,及淋巴细胞表面粘附分子CD11b ,CD18,CD14和L 选择素 (L selectin)的表达。结果显示 :同型半胱氨酸在低浓度2 0 μmol/L时明显增加CD11b和CD18在各种白细胞表面的表达 ,同时也增加了CD14在单核及中性粒细胞的表达。这种作用随同型半胱氨酸浓度升高而增强 ,但当浓度升至等于或大于 1mmol/L时 ,各种粘附分子的表达反而降低。同型半胱氨酸使各种细胞类型表面L selectin降低。此结果表明同型半胱氨酸可改变白细胞表面粘附分子的表达 ,可能在体内通过此途经导致白细胞粘附并游出血管内皮。 | 郭雪微 Dudman NP | 2001 | 基础医学与临床2001，21，2： | 6 |
| 5 | 儿童危重症器官功能不全评分和功能预后的关系显示文摘目的儿童危重症常发生短期及长期致残致死事件,危重症患儿严重器官功能不全和院内病死率显著升高相关,但儿童器官功能不全评分做为危重症功能预后预测指标的能力尚未得到评估。设计一项前瞻性观察性队列研究数据进行二次分析。场所一家多学科、三级学术性PICU。 | Matics TJ Pinto NP Sanchez-Pinto N 方伯梁(译) 钱素云(校) | 2019 | 中国小儿急救医学2019，26，10： | 6 |
| 6 | Management of difficult bile duct cannulation in ERCP显示文摘In Encoscopic Retrograde Cholangiopancreatography(ERCP),the main concern is to gain access into the bile duct while avoiding the pancreatic duct because of the risk of post-ERCP pancreatitis.Diffi cult cannulation is defined as a situation where the endoscopist,using his/her regularly used cannulation technique,fails within a certain time limit or after a certain number of unsuccessful attempts.Different methods have been developed to manage diffi cult cannulation.The most common solution is to perform a precut papillotomy either with a needle knife or with a sphincterotome with or without a guide wire.This review describes different methods to overcome cases of difficult cannulation.We will discuss the success rate and complication rates associated with different methods of reaching the biliary tract. | Marianne Udd Leena Kylnp Jorma Halttunen | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 4 |
| 7 | 明确儿童重症监护后综合征概念:PICS-p架构显示文摘背景过去的数十年里,儿童重症医学的进步挽救了很多生命,而现代医学已更多的着眼于尽量减少并发症。重症龄护后综合征(Post—Intensive Care Syndrome,PICS)为常见于重症监护出院患者的一系列认知、身体及精神健康损害。成人PICS概念已较为明确,但在儿童则尚不明确。 | Manning JC Pinto NP Rennick JE 方伯梁(译) 钱素云(校) | 2018 | 中国小儿急救医学2018，25，6： | 3 |
| 8 | 自体骨软骨镶嵌移植术修复关节软骨缺损显示文摘目的 :回顾性分析关节镜下自体骨软骨镶嵌式移植术治疗负重面关节软骨损伤的可行性。方法 :采用 Smith+Nephew镶嵌式骨软骨移植器 ,在关节镜下挖取膝关节非负重关节面骨软骨条 ,并将之移植修复膝关节负重面的局灶性软骨缺损。结果 :手术 15例 ,术后随访 7~ 12个月 ,平均 9个月 ,均达到优良效果。结论 :自体关节骨软骨镶嵌移植术对关节负重面局灶性软骨缺损有较好、确实的治疗效果。 | 张永红 高岩 NP Suedkam p DJ Schaefer | 2003 | 实用骨科杂志2003，9，2： | 3 |
| 9 | Endoscopic treatment of pancreatic pseudocysts显示文摘 | L. Weckman M.-L. Kyl?np?? P. Puolakkainen J. Halttunen | 2006 | Surgical Endoscopy2006，，4： | 2 |
| 10 | A simple technique for quantitation of low levels of DNA damage in individual cells显示文摘 | Singh NP Mccoy MT Tice RR | 1988 | Exp Cell Res1988，，175： | 2 |
| 11 | The Clinical Course of Acute Pancreatitis and the Inflammatory Mediators That Drive It显示文摘 | Leena Kyl?np?? Zoltán Rakonczay Derek A. O’Reilly David A. Hart | 2012 | International Journal of Inflammation2012，，： | 2 |
| 12 | Reperfusion induces myocardial apoptotic cell death显示文摘 | Zhao ZQ Nakamura M Wang NP | 2000 | Cardiovasc Res2000，45，3： | 2 |
| 13 | Acetaldehyde: genotoxity and cytotoxity in human lymphcyte显示文摘 | Singh NP Khan A | 1995 | Mutation research1995，337，1： | 2 |
| 14 | Cryptdins: endogenous antibiotic peptides of small intestinal Paneth cells显示文摘 | Harwig SS Eisenhauer PB Chen NP | 1995 | Adv Exp Med Biol1995，371，： | 2 |
| 15 | The effects of temperature and pressure on the performance of carboxen/PDMS fibres during solid phase microextraction (SPME) of headspace volatiles from cooked and raw turkey breast显示文摘 | Brunton NP | 2001 | Flavour and Fragrance Journal2001，16，4： | 2 |
| 16 | Periodontal diagnosis in daily practice显示文摘 | Lang NP | 1995 | Int Dent J1995，45，1： | 2 |
| 17 | The role of diaschisis in stroke recovery显示文摘 | Seitz RJ Azari NP Knorr U | 1999 | Stroke1999，30，： | 2 |
| 18 | Pathology grading of colon cancer surgical resection and its association with survival:a retrospective observational study显示文摘 | West NP Morris E J Rotimi O | | 0，，09： | 2 |
| 19 | Radiation damage and immune suppression in splenic mononuclear cell populations显示文摘 | Harrington NP Chambers KA Rose WM | 1997 | Clin Exp Immunol1997，107，： | 2 |
| 20 | Disordered thymus function and endocrine control as one of the bases for the development of a late postradiation immunodeficiency显示文摘 | Savina NP | 1995 | Radiat Biol Radioecol1995，35，4： | 2 |
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