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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | CD14,a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein显示文摘 | Wright S D Ramos R A Tobias P S | 1990 | Science1990，249，4975： | 2 |
| 3 | Isopentenyl diphosphate isomerase and prenyltransferase activities in rubiaceous and apocynaceous cultures显示文摘 | Ramos V A C Vander H R Verpoorte R | 1998 | Phytochemistry1998，48，： | 1 |
| 4 | Characterization of traditional and exotic apple varieties from Portugal part 1-nutritional, phytochemical and sensory evaluation显示文摘 | FELICIANO R P ANTUNES C RAMOS A | 2010 | Journal of Functional Foods2010，2，1： | 1 |
| 5 | Further insights into the Ru nanoparticles carbon interactions and their role in the catalytic properties 显示文摘 | Alarc6n M C Valiente A M Ramos I R | 2005 | Carbon2005，43，13： | 1 |
| 6 | Practical stability of switched systems without a common equilibria and governed by a time-dependent switching signal显示文摘 | KUIAVA R RAMOS R A POTA H R | 2013 | European Journal of Control2013，19，3： | 1 |
| 7 | Effects of allelopathic compounds of compollen on respiration and cell dibision of watermelon显示文摘 | Ortega R C Anaya A L Ramos A L | 1988 | J Chem Ecol1988，，： | 1 |
| 8 | Thermo- and pH-sensitive IPN hydrogels based on PNIPAAm and PVA-Ma networks with LCST tailored close to human body temperature 显示文摘 | WENCESLAU A C SANTOS F G RAMOS E R F NAKAMURA C V RUBlRA A F MUNIZ E C | 2012 | Materials Science and Engineering C2012，32，5： | 1 |
| 9 | The Asiatic Clam Corbicula-Fluminea(Muller,1774) (Bivalvia,Corbiculidae) in Europe显示文摘 | Moreno D Ramos M A | 1993 | American Malacological Bulletin1993，10，1： | 1 |
| 10 | Adsorption of fluoride from aqueous solution on aluminum-impregnated carbon显示文摘 | Ramos L R Ovalle-Turrubiartes J Sanchez-Castillo M A | 1999 | Carbon1999，37，： | 1 |
| 11 | Status and conservation of the giant European freshwater pearl mussel (Margaritifera auricularia) (Spengler,1793)(Bivalvia:Unionidea)显示文摘 | Araujo R Ramos M A | 2000 | Biological Conservation2000，96，2： | 1 |
| 12 | Upregulation of acidic fibroblast growth factor during development of experimental lung fibrosis显示文摘 | Barrios R Pardo A Ramos C | | 0，，： | 1 |
| 13 | Mathematical simulation and physical modeling of unsteady fluid flow in a water model of a slab mold显示文摘 | Ramos Banderaset A Morales R D | 2004 | Metallurgical and Material Transactions: B2004，35，3： | 1 |
| 14 | Effects of allelopathic compounds of corn pollen on respiration and cell division of watermelon 显示文摘 | Ortega R C Anaya A L Ramos L | 1988 | Journal of Chemical Ecology1988，14，1： | 1 |
| 15 | A new methodology for the coordinated design of robust decentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
| 16 | A newmethodology for the coordinated design of robustdecentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEETransactions on Power Systems2004，19，1： | 1 |
| 17 | Ectopic thyroid presenting as a submandibular mass显示文摘 | BERSANETI J A SILVA R D RAMOS R R | 2011 | Head Neck Pathol2011，5，： | 1 |
| 18 | Transverse myelitis affect- ing more than 4 spinal segments associated with systemic lupus erythematosus: clinical, immunological, and radiological characteristics of 22 patients 显示文摘 | Espinosa G Mendizabal A Minguez S Ramo - Tello C Capellades J Olive A Cervera R | 2010 | Semin Arthritis Rheum2010，39，4： | 1 |
| 19 | Control design of a STATCOM with energy storage system for stability and power quality improvements显示文摘 | KUIAVA R RAMOS R A BRETAS N G | | 0，，06： | 1 |
| 20 | Phylogeography of the endangered rosewood Dalbergia nigra (Fabaceae): insights into the evolutionary history and conservation of the Brazilian Atlantic Forest显示文摘 | Ribeiro R A Lemos J P Ramos A C S | 2011 | Heredity2011，106，： | 1 |
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