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| 1 | TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data显示文摘The rapid development of high-throughput sequencing techniques has led biology into the big-data era.Data analyses using various bioinformatics tools rely on programming and command-line environments,which are challenging and time-consuming for most wet-lab biologists.Here,we present TBtools(a Toolkit for Biologists integrating various biological data-handling tools),a stand-alone software with a userfriendly interface.The toolkit incorporates over 130 functions,which are designed to meet the increasing demand for big-data analyses,ranging from bulk sequence processing to interactive data visualization.A wide variety of graphs can be prepared in TBtools using a new plotting engine('JIGplot')developed to maximize their interactive ability;this engine allows quick point-and-click modification of almost every graphic feature.TBtools is platform-independent software that can be run under all operating systems with Java Runtime Environment 1.6 or newer.It is freely available to non-commercial users at http://gffzz188fe103f8f1460asw0wkvfo00pxq6q65.ffgz.tsg.suse.edu.cn/CJ-Chen/TBtools/releases. | Chengjie Chen Hao Chen Yi Zhang Hannah R.Thomas Margaret H.Frank Yehua He Rui Xia | 2020 | Molecular Plant2020，13，8： | 805 |
| 2 | White grapes arose through the mutation of two similar and adjacent regulatory genes显示文摘 | Amanda R.Walker ElizabethLee JochenBogs Debra A. J.McDavid Mark R.Thomas Simon P.Robinson | 2007 | The Plant Journal2007，，5： | 3 |
| 3 | 机车径向转向架对轮轨磨耗的影响显示文摘自从美国GM公司的电气动力部(EMD)为重载货运机车设计的3轴径向转向架在1993年投产以来,已运行了1.12多亿km。到1996年底,将有超过800台应用这种新转向架技术的交流和直流传动机车投入使用。相对容易得到的车轮磨耗数据表明,尽管粘着显著增加(起动重载列车时达45%,运行时达35%或更高),但轮缘磨耗实际上已消失,踏面磨耗也没增加。车轮磨耗数据还表明,车轮寿命将可能延长一倍,即使由于磨耗到限踏面进行恢复外形加工之后的车轮也如此。这是由于很低的轮缘磨耗减少了在修整车轮过程中的去料量。车轮磨耗结果也提出了改变铁路传统旋轮制度的新课题。径向转向架对减少钢轨磨耗的影响很难估算,本文只探讨几种钢轨磨耗的情况。最近的实验可使人们对轮-轨冲角对轮轨磨耗的影响有更深刻的认识。提出将现场和实验数据与费用模型结合起来以预计出由于改善钢轨和车轮磨耗而带来的寿命期成本节省量的方法。 | Curt A.Swenson R.Thomas Scott 刘爱东 曾令岩 | 1999 | 国外内燃机车1999，，6： | 2 |
| 4 | A single‐centre experience of chemoradiotherapy for rectal cancer: is there potential for nonoperative management?显示文摘 | R. S. J.Dalton R.Velineni M. E.Osborne R.Thomas S.Harries A. S.Gee I. R.Daniels | 2012 | Colorectal Disease2012，，5： | 2 |
| 5 | N:P ratios, light limitation, and cyanobacterial dominance in a subtropical lake impacted by non-point source nutrient pollution显示文摘 | Karl E. Havens R.Thomas James Therese L. East Val H. Smith | 2002 | Environmental Pollution2002，，3： | 1 |
| 6 | Sequestration of the Lung Arising From the Circumflex Coronary Artery显示文摘 | R.Thomas Temes William A Talbot Ysela M Carrillo Gregory M Keck Jorge A Wernly | 1998 | The Annals of Thoracic Surgery1998，，： | 1 |
| 7 | Geofluids:Developments in Microthermometry,Spectroscopy,Thermodynamics and Stable Isotopes显示文摘Fluid(and melt)inclusion studies have shown a marked development in the last decades,as indicated by the increasing number of papers and as covered under major themes in specialized meetings(e.g.ECROFI in Europe,PACROFI in America,ACROFI in Asia).However,a basic text book is lacking in current literature,available information being either somewhat outdated(e.g.Roedder,1984)or scattered in multi-author'short course',mainly organized | V.Hurai M.Huraiovà M.Slobodnik R.Thomas Jacques Touret | 2016 | Geoscience Frontiers2016，7，1： | 1 |
| 8 | Characterisation of the Breaking Force of Latex Particle Aggregates by Micromanipulation显示文摘 | ZhibingZhang Maria L.Sisk HishamMashmoushy Colin R.Thomas | 2000 | Part Part Syst Charact2000，，6： | 1 |
| 9 | The use of adenosine for repair of penetrating cardiac injuries: a novel method显示文摘 | Roger Lim Inderjit S Gill R.Thomas Temes Charles E Smith | 2001 | The Annals of Thoracic Surgery2001，，5： | 1 |
| 10 | White grapes arose through the mutation of two similar and adjacent regulatory genes显示文摘 | Amanda R.Walker ElizabethLee JochenBogs Debra A. J.McDavid Mark R.Thomas Simon P.Robinson | 2007 | The Plant Journal2007，，5： | 1 |
| 11 | Esophageal dilation: simple and effective treatment for adults with eosinophilic esophagitis and esophageal rings and narrowing显示文摘 | M.Bohm J. E.Richter S.Kelsen R.Thomas | 2010 | Diseases of the Esophagus2010，，： | 1 |
| 12 | ATP-binding cassette transporters at the zebrafish blood-brain barrier and the potential utility of the zebrafish as an in vivo model显示文摘The brain is protected from toxins by a tightly regulated network of specialized cells,including endothelial cells,pericytes,astrocyes,and neurons,known collectively as the blood-brain barrier(BBB).This selectively permeable barrier permits only the most crucial molecules essential for brain function to enter and employs a number of different mechanisms to prevent the entry of potentially harmful toxins and pathogens.In addition to a physical barrier comprised of endothelial cells that form tight junctions to restrict paracellular transport,there is an active protective mechanism made up of energy-dependent transporters that efflux compounds back into the bloodstream.Two of these ATP-binding cassette(ABC)transporters are highly expressed at the BBB:P-glycoprotein(P-gp,encoded by the ABCB1 gene)and ABCG2(encoded by the ABCG2 gene).Although a number of in vitro and in vivo systems have been developed to examine the role that ABC transporters play in keeping compounds out of the brain,all have inherent advantages and disadvantages.Zebrafish(Danio rerio)have become a model of interest for studies of the BBB due to the similarities between the zebrafish and mammalian BBB systems.In this review,we discuss what is known about ABC transporters in zebrafish and what information is still needed before the zebrafish can be recommended as a model to elucidate the role of ABC transporters at the BBB. | Jordan M.Hotz Joanna R.Thomas Emily N.Katz Robert W.Robey Sachi Horibata Michael M.Gottesman | 2021 | Cancer Drug Resistance2021，4，3： | 0 |
| 13 | NATURAL HISTORY OF OCCLUDABLE ANGLES AND PRIMARY ANGLE CLOSURE - KEY TO TREATMENT显示文摘Purpose: To report the 5 year progression of occludable angles to primary angle closure (PAC) and PAC to primary angle closure glaucoma (PACG) in a south Indian population. Material and Methods: All persons between 30 and 60 years of age, residing in 12 randomly chosen clusters representing Vellore town were invited for an ophthalmic examination in 1995. 972 of | R.Thomas R.Parikh R.George J.P.Muliyel | 2003 | 国际眼科杂志2003，3，1： | 0 |
| 14 | 西欧晚泥盆世法门期早期石燕贝类腕足动物显示文摘比利时新基尔里斯(Senzeilles)地区是西欧晚泥盆世地层研究的一个经典地区,也是法门期石燕贝类腕足动物的重要比产区。然而针对本区弓石燕类的现代研究却较为匮乏,此外,早期的分类工作已难以满足现代专题性的课题资料要求(即层位清楚、鉴定准确的系统分类工作),因此对比利时地区法门期的“弓石燕属”足动物进行系统古生物学研究及对比具有重要意义。当前研究在华南现有成果的基础上,通过对壳面特征(贝体大小、基面特征、微细纹饰特征、中槽壳褶发生方式)及内部构造(齿板特征、内窗板特征等)的系统研究及对比,拓展了Plicapustula属的定义,即:褶上和褶间均发育微瘤纹饰。欧洲的Plicapustula属分子褶间均发育放射状细瘤微细纹饰,而华南的该属分子褶间均缺失微瘤纹饰。由于该特征存在明显的地域性,因此当前研究以此为依据建立了Paraplicapustula亚属,并将欧洲的标本归入该亚属。此外,本文还首次识别并描述了欧洲的Sinospirifer属。大部分西欧Sinospirifer属和Plicapustula属与华南地区相比,在种级组成上存在明显的差异,包括标本大小、齿板是否增厚、壳褶数目及分枝情况、微细纹饰类型等。本文共描述了上述2属的5种,包括1新亚属、3新种[Plicapustula(Paraplicapustula) eleganta subgen. et sp. nov. Ma and Wang, Plicapustula(Paraplicapustula) magna subgen. et sp.nov. Ma and Wang, Sinospirifer transversus sp. nov. Ma and Wang, Plicapustula(Paraplicapustula) sp.及Sinospirifer subextensus(Martelli, 1902)]。 | 王艺凝 马学平 Volker Ebbighausen R.Thomas Becker | 2023 | 古生物学报2023，62，3： | 0 |
| 15 | In search of effective therapies to overcome resistance to Temozolomide in brain tumours显示文摘Glioblastoma multiforme is the most common and lethal brain tumour-type.The current standard of care includes Temozolomide(TMZ)chemotherapy.However,inherent and acquired resistance to TMZ thwart successful treatment.The direct repair protein methylguanine DNA methyltransferase(MGMT)removes the cytotoxic O6-methylguanine(O6-MeG)lesion delivered by TMZ and so its expression by tumours confers TMZ-resistance.DNA mismatch repair(MMR)is essential to process O6-MeG adducts and MMR-deficiency leads to tolerance of lesions,resistance to TMZ and further DNA mutations.In this article,two strategies to overcome TMZ resistance are discussed:(1)synthesis of imidazotetrazine analogues-designed to retain activity in the presence of MGMT or loss of MMR;(2)preparation of imidazotetrazine-nanoparticles to deliver TMZ preferably to the brain and tumour site.Our promising results encourage belief in a future where better prognoses exist for patients diagnosed with this devastating disease. | Kaouthar Bouzinab Helen Summers Jihong Zhang Malcolm F.G.Stevens Christopher J.Moody Lyudmila Turyanska Neil R.Thomas Pavel Gershkovich Marianne B.Ashford Emily Vitterso Lisa C.D.Storer Richard Grundy Tracey D.Bradshaw | 2019 | Cancer Drug Resistance2019，2，4： | 0 |
| 16 | 一个遭受人为富营养化的亚热带大湖的快速生态变化显示文摘本文描述人类活动是如何影响一个亚热带大湖——美国佛罗里达奥基乔比湖(0keechobee)的生态状况的。自20世纪初以来,该湖经历了水文变化和地貌变化,是近已出现加速富营养化现象。总磷浓度增加了1倍;氮磷比(氮:磷)下降了50%;湖泊沉积物也累积了大量磷。生物群落已经历了看来是因富营养化所致的变化:贫毛类环虫在大型底牺生物中占据优势;蓝菌藻已取代硅藻成为优势浮游植物;氮限制的出现次数增加;固氮已成为所输入的主要途径。有证据表明:该湖已达到一种新的生态稳定状态,通过沉积物的营养输入来缓冲变化。湖水的深度变浅和风积物悬浮有助于这种局势的形成。 | Karl Havens Nicholas Aumen R.Thomas James 张康生 | 1996 | 人类环境杂志1996，25，3： | 0 |
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