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| 1 | Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury显示文摘Mild traumatic brain injury(TBI), also called concussion, initiates sequelae leading to motor deficits, cognitive impairments and subtly compromised neurobehaviors. While the acute phase of TBI is associated with neuroinflammation and nitroxidative burst, the chronic phase shows a lack of stimulation of the neurorepair process and regeneration. The deficiency of nitric oxide(NO), the consequent disturbed NO metabolome, and imbalanced mechanisms of S-nitrosylation are implicated in blocking the mechanisms of neurorepair processes and functional recovery in the both phases. Hypoxia inducible factor-1 alpha(HIF-1α), a master regulator of hypoxia/ischemia, stimulates the process of neurorepair and thus aids in functional recovery after brain trauma. The activity of HIF-1α is regulated by NO via the mechanism of S-nitrosylation of HIF-1α. S-nitrosylation is dynamically regulated by NO metabolites such as S-nitrosoglutathione(GSNO) and peroxynitrite. GSNO stabilizes, and peroxynitrite destabilizes HIF-1α. Exogenously administered GSNO was found not only to stabilize HIF-1α and to induce HIF-1α-dependent genes but also to stimulate the regeneration process and to aid in functional recovery in TBI animals. | Mushfiquddin Khan Hamza Khan Inderjit Singh Avtar K.Singh | 2017 | Neural Regeneration Research2017，12，5： | 7 |
| 2 | Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice:involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms显示文摘Spinal cord injury(SCI)is associated with high production and excessive accumulation of pathological 4-hydroxy-trans-2-nonenal(4-HNE),a reactive aldehyde,formed by SCI-induced metabolic dysregulation of membrane lipids.Reactive aldehyde load causes redox alteration,neuroinflammation,neurodegeneration,pain-like behaviors,and locomotion deficits.Pharmacological scavenging of reactive aldehydes results in limited improved motor and sensory functions.In this study,we targeted the activity of mitochondrial enzyme aldehyde dehydrogenase 2(ALDH2)to detoxify 4-HNE for accelerated functional recovery and improved pain-like behavior in a male mouse model of contusion SCI.N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide(Alda-1),a selective activator of ALDH2,was used as a therapeutic tool to suppress the 4-HNE load.SCI was induced by an impactor at the T9–10 vertebral level.Injured animals were initially treated with Alda-1 at 2 hours after injury,followed by once-daily treatment with Alda-1 for 30 consecutive days.Locomotor function was evaluated by the Basso Mouse Scale,and pain-like behaviors were assessed by mechanical allodynia and thermal algesia.ALDH2 activity was measured by enzymatic assay.4-HNE protein adducts and enzyme/protein expression levels were determined by western blot analysis and histology/immunohistochemistry.SCI resulted in a sustained and prolonged overload of 4-HNE,which parallels with the decreased activity of ALDH2 and low functional recovery.Alda-1 treatment of SCI decreased 4-HNE load and enhanced the activity of ALDH2 in both the acute and the chronic phases of SCI.Furthermore,the treatment with Alda-1 reduced neuroinflammation,oxidative stress,and neuronal loss and increased adenosine 5′-triphosphate levels stimulated the neurorepair process and improved locomotor and sensory functions.Conclusively,the results provide evidence that enhancing the ALDH2 activity by Alda-1 treatment of SCI mice suppresses the 4-HNE load that attenuates neuroinflammation and neurodegeneration,promotes the neurorepair process,and improves functional outcomes.Consequently,we suggest that Alda-1 may have therapeutic potential for the treatment of human SCI.Animal procedures were approved by the Institutional Animal Care and Use Committee(IACUC)of MUSC(IACUC-2019-00864)on December 21,2019. | Mushfiquddin Khan Fei Qiao Pavan Kumar S.M.Touhidul Islam Avtar K.Singh Jeseong Won Inderjit Singh | 2022 | Neural Regeneration Research2022，17，1： | 3 |
| 3 | Bilateral uveitis associated with nivolumab therapy for metastatic melanoma: a case report显示文摘Dear Editor,I am Dr.Daniel Russell Richardson from the West Virginia University Eye Institute in Morgantown,West Virginia,United States.I write to present a case of uveitis associated with nivolumab,which is a promising new immune checkpoint inhibitor(ICI)for metastatic melanoma and non-small cell lung carcinoma with expanding indications.As the use of nivolumab continues to increase,ophthalmologists must be aware of uveitis as an adverse event.Modulating | Daniel Russell Richardson Brian Ellis Inderjit Mehmi Monique Leys | 2017 | International Journal of Ophthalmology(English edition)2017，10，7： | 3 |
| 4 | Therapeutic exploitation of the S-nitrosoglutathione/S-nitrosylation mechanism for the treatment of contusion spinal cord injury显示文摘Contusion spinal cord injury(SCI)is a major medical and socio-economic problem globally.The incidence of SCI is highest among young adults due to motor vehicle accidents,military or sports injuries,and violence(Selvarajah et al.,2014).The elderly and children are also at risk due to falls and accidents.SCI causes neurodegeneration,with profound loss of locomotor and sensory functions(Siddiqui et al.,2015).Pain and depression are also prevalent in a majority of SCI patients.Expenses for severe SCI are high:initial hospitalization,rehabilitation,and most likely the continuing need for a caregiver and medical care.SCI survivors with less severe injuries usually face lower but still hefty medical bills.However,people≥50 years old with severe SCI may face medical expenses of over$1.8 million during their lifetimes.These injuries also affect spouses and family members,emotionally and financially,and most injuries jeopardize employment for those affected. | Mushfiquddin Khan Inderjit Singh | 2019 | Neural Regeneration Research2019，14，6： | 3 |
| 5 | Inhibition of the AMPK/nNOS pathway for neuroprotection in stroke显示文摘<正>Stroke ranks fourth among all causes of death and is the major cause of long-term disability in the United States.Furthermore,it is associated with significant morbidity/mortality and a direct/indirect cost of approximately$65 billion annually(Roger et al.,2012).Other than thrombolysis by tissue plasminogen activator(t PA),which offers only a short window of treatment(~3–4 hours),an effective neuroprotective or functional recovery therapy is not available mainly because | Mushfiquddin Khan Inderjit Singh | 2016 | Neural Regeneration Research2016，11，3： | 2 |
| 6 | Experimental Complexities in Evaluating the Allelopathic Activities in Laboratory Bioassays: A Case Study显示文摘 | Inderjit | 2006 | Soil Biology&Biochemistry2006，，38： | 1 |
| 7 | Algal allelopathy 显示文摘 | INDERJIT DAKSHINI K M M | 1994 | Botanical Reviews1994，60，2： | 1 |
| 8 | Effect of phenolic compounds on selected soil properties显示文摘 | Inderjit Mallik A U | 1997 | Forest Ecolgy Manage1997，，92： | 1 |
| 9 | Plant allelochemical interference or soilchemical ecology? 显示文摘 | Inderjit D Weiner J | 2001 | Perspectives in Plant Ecology Evolution and Systematics2001，4，： | 1 |
| 10 | Plant allelochemical interference or soil chemical ecology显示文摘 | INDERJIT D WEINER J | 2001 | Perspectives in Plant Ecology Evolution and Systematics2001，4，： | 1 |
| 11 | Is separating resource com- petition from allelopathy realistic? 显示文摘 | Inderjit N Y del Moral R | 1997 | Bot Rev1997，63，： | 1 |
| 12 | Algal allelopathy显示文摘 | INDERJIT D DAKSHINI K M M | 1994 | Botanical Review1994，60，： | 1 |
| 13 | Exotic invasive plant accumulates native soil pathogens which inhibit native plants显示文摘 | Mangla S Inderjit Callaway R M | 2008 | Journal of Ecology2008，96，： | 1 |
| 14 | Ecophysiological aspects of allelopathy显示文摘 | INDERJIT DUKE S O | 2003 | Planta2003，217，4： | 1 |
| 15 | Experimental designs for the study of allelopathy显示文摘 | Inderjit Callaway R M | 2003 | Plant Soil2003，256，： | 1 |
| 16 | Ecophysiological aspects of allelopathy 显示文摘 | INDERJIT S DUKE SO | 2003 | Planta2003，217，： | 1 |
| 17 | Experimental designs for the study of allelopathy显示文摘 | INDERJIT C CALLAWAY R M | 2003 | Plant and Soil2003，256，： | 1 |
| 18 | Plant phenolics in allelopathy 显示文摘 | Inderjit | 1996 | Bot Rev1996，62，： | 1 |
| 19 | Soil: Enviroment effects on allelochemical activity 显示文摘 | Inderjit | 2001 | Agronomy Journal2001，1，93： | 1 |
| 20 | Exotic invasive plant accumulates native soil pathogens which inhibit native plants显示文摘 | Mangla S Inderjit Callaway R M | 2008 | Journal of Ecology2008，96，： | 1 |
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