维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

1篇 您的检索式：作者名="Neil R.Thomas"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	In search of effective therapies to overcome resistance to Temozolomide in brain tumours显示文摘Glioblastoma multiforme is the most common and lethal brain tumour-type.The current standard of care includes Temozolomide(TMZ)chemotherapy.However,inherent and acquired resistance to TMZ thwart successful treatment.The direct repair protein methylguanine DNA methyltransferase(MGMT)removes the cytotoxic O6-methylguanine(O6-MeG)lesion delivered by TMZ and so its expression by tumours confers TMZ-resistance.DNA mismatch repair(MMR)is essential to process O6-MeG adducts and MMR-deficiency leads to tolerance of lesions,resistance to TMZ and further DNA mutations.In this article,two strategies to overcome TMZ resistance are discussed:(1)synthesis of imidazotetrazine analogues-designed to retain activity in the presence of MGMT or loss of MMR;(2)preparation of imidazotetrazine-nanoparticles to deliver TMZ preferably to the brain and tumour site.Our promising results encourage belief in a future where better prognoses exist for patients diagnosed with this devastating disease.	Kaouthar Bouzinab Helen Summers Jihong Zhang Malcolm F.G.Stevens Christopher J.Moody Lyudmila Turyanska Neil R.Thomas Pavel Gershkovich Marianne B.Ashford Emily Vitterso Lisa C.D.Storer Richard Grundy Tracey D.Bradshaw	2019	Cancer Drug Resistance2019，2，4：	0

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费