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| 1 | The multidisciplinary team meeting improves staging accuracy and treatment selection for gastro‐esophageal cancer显示文摘 | A. R.Davies D. A. C.Deans I.Penman J. N.Plevris J.Fletcher L.Wall H.Phillips H.Gilmour D.Patel A.De Beaux S.Paterson‐Brown | 2006 | Diseases of the Esophagus2006，，6： | 1 |
| 2 | Expression of Matrix Metalloproteases in Inflammatory Bowel Disease显示文摘 | M. D.BAUGH G. S.EVANS A. P.HOLLANDER D. R.DAVIES M. J.PERRY A. J.LOBO C. J.TAYLOR | 2006 | Annals of the New York Academy of Sciences2006，，1： | 1 |
| 3 | Peroxidase‐dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance显示文摘 | Laurence V.Bindschedler JuliaDewdney Kris A.Blee Julie M.Stone TsuneakiAsai JuliaPlotnikov CarineDenoux TezniHayes ChrisGerrish Dewi R.Davies Frederick M.Ausubel G.Paul Bolwell | 2006 | The Plant Journal2006，，6： | 1 |
| 4 | Gas flow in rotary kilns显示文摘This paper describes an experimental investigation on the flow characteristics within a rotating cylinder containing a rolling bed of sand.The axis of the cylinder was horizontal and there was no axial bulk flow of particles.The velocity field of the gas flowing through the cylinder was measured by hot-wire anemometry.The measurements indicate that the velocity field is asymmetric with respect to a diameter perpendicular to the granular bed.CFD calculations confirm this finding.The gas velocity profiles are crucial in determining heat transfer from gas to solid. | Patrick R.Davies Michael J.S.Norton D.Ian Wilson John F.Davidson David M.Scott | 2010 | Particuology2010，8，6： | 1 |
| 5 | 受构造控制的热液白云岩储集层显示文摘受构造控制的热液白云岩(HTD)储集岩相及其伴生的淋滤石灰岩相是北美的主要产油岩层,也是目前全球日益增长的勘探热点。在美国的密歇根、阿巴拉契亚、加拿大东部和美国其它盆地的奥陶系(局部区域的志留系和泥盆系)以及加拿大西部沉积盆地中的泥盆纪和密西西比纪的热液白云岩和淋滤石灰岩层系中有多套含油层系。在沿裂开的大西洋边缘分布的侏罗系主岩和阿拉伯海湾地区以及其它地区的侏罗系-白垩系中也存在热液白云岩和淋滤石灰岩含油层系。
热液白云岩化作用的定义为:在埋藏条件下(通常埋藏较浅),由于流体(典型的极咸流体)作用形成的白云岩化作用,其温度(T)和压力(P)高于围岩。HTD储集岩相热液源的求证需要综合分析热埋藏史图和流体包体温度数据等。热液白云岩储集岩相是热液矿床范畴的一种,热液矿床还包括沉积-蒸发型铅-锌矿矿体和以HTD为主岩的密西西比河谷型硫化物沉积。这三种热液矿反映出明显受伸展断层和(或)走向滑移(扭性)断层控制的特征,流体的流动一般集中在构造转换拉张和扩散的位置,以及断层的上盘。扭性断层负向花状构造之上的转换拉张塌陷是有利于钻探HTD储集岩相的位置。
在交代模型与孔隙填充模型中的鞍状白云石以HTD相为特征。对于许多储集岩来说,基质交代白云石和鞍状白云石似乎基本上为同期成形,而且具有相同的流体和温度条件。原始主岩的岩相对白云石化作用的横向延展、生成物结构、孔隙类型以及孔隙体积有着较大的影响。角砾岩、条带结构、剪切微裂缝以及其它岩石特征反映了紧临活动断层处的短期剪切应力和孔隙流体压力的瞬变现象。高温热液脉动现象(指“强制熟化作用”)可能会改变主体石灰岩中干酪根的特性。基底隆起、下伏砂岩(和/或碳酸盐岩)蓄水层(可能为超压条件)、上覆及层内的页岩封闭层和弱透水层也可能限制或影响HTD的定位。
由于还存在许多疑问和不确定性难以解释,尤其是有关镁和盐水的来源及质量平衡等方面的问题,所以HTD远景带的识别和有效勘探还有待于进一步加深认识。随着三维地震成像和地震异常体的勘测技术的应用,结合水平钻探倾斜一线型远景带(通过构造塌陷确定),将有助于降低勘探风险。 | Graham R.Davies 康新荣(译) 黎发文(校) | 2007 | 国外油气地质信息2007，，4： | 0 |
| 6 | 碳酸盐岩储层的构造控制热液蚀变显示文摘本期(2006年11期)《AAPG Bulletin》专辑的内容是碳酸盐岩及其储层的构造控制热液蚀变。这种蚀变涉及碳酸盐主岩的一系列岩相变化,包括硫化物矿床、热液白云岩和淋溶石灰岩,它在很多情况下都会对储层的类型、几何形态、性能和分布产生重大影响。在北美地区,热液白云岩(HTD)储层的勘探和开发已有很长历史,其最早的油气发现是在美国东北部的奥陶系莱马-印第安纳(Lima-Indiana)和其它构造带(Hurley和Budros,1990;Wickstrom等,1992),而目前在美国东北部和加拿大东部的密歇根盆地和阿巴拉契亚盆地北部的特伦顿-布莱克里弗(Trenton-BlackRiver)成藏层带及其他层位,仍继续有油气发现。 | Langhorne B.Smith Jr. Graham R.Davies 白振瑞(译) | 2007 | 石油地质科技动态2007，，5： | 0 |
| 7 | 构造控制热液白云岩储集相综述(七)显示文摘19凹陷的成因和勘探意义
19。1特征和机理凹陷(sag)在含热液白云岩(HTD)的碳酸盐岩地层项部是可以用地震方法辩认的洼地(depression)(图24—26,表1),这种凹陷显示与母岩地层中的HTD产状具有较高的正相关。 | Graham R.Davies Langhorne B SmithJr 刘春(译) | 2008 | 国外石油动态2008，，21： | 0 |
| 8 | CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4^(+)T cells显示文摘As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency(PAD),analysis of affected patients could yield insights into T-cell differentiation and explain how environmental exposures modify clinical phenotypes conferred by single-gene defects.CD57 marks dysfunctional T cells that have differentiated after antigenic stimulation.Indeed,while circulating CD57^(+)CD4^(+)T cells are normally rare,we found that they are increased in patients with PAD and markedly increased with CTLA4 haploinsufficiency or blockade.We performed single-cell RNA-seq analysis of matched CD57^(+)CD4^(+)T cells from blood and tonsil samples.Circulating CD57^(+)CD4^(+)T cells(CD4cyt)exhibited a cytotoxic transcriptome similar to that of CD8^(+)effector cells,could kill B cells,and inhibited B-cell responses.CTLA4 restrained the formation of CD4cyt.While CD57 also marked an abundant subset of follicular helper T cells,which is consistent with their antigen-driven differentiation,this subset had a preexhaustion transcriptomic signature marked by TCF7,TOX,and ID3 expression and constitutive expression of CTLA4 and did not become cytotoxic even after CTLA4 inhibition.Thus,CD57^(+)CD4^(+)T-cell cytotoxicity and exhaustion phenotypes are compartmentalised between blood and germinal centers.CTLA4 is a key modifier of CD4^(+)T-cell cytotoxicity,and the pathological CD4cyt phenotype is accentuated by infection. | Yuwei Hao Bahar Miraghazadeh Rochna Chand Ainsley R.Davies Chelisa Cardinez Kristy Kwong Morgan B.Downes Rebecca A.Sweet Pablo F.Cañete Lloyd J.D’Orsogna David A.Fulcher Sharon Choo Desmond Yip Geoffrey Peters Sonia Yip Matthew J.Witney Maxim Nekrasov Zhi-Ping Feng David C.Tscharke Carola G.Vinuesa Matthew C.Cook | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 9 | Identification of a female murder victim found in Burgenland,Austria in 1993显示文摘In 1993,the skeletal remains of a female corpse were found in Burgenland,Austria.Initial identification of the approximately 25–35-year-old female appeared impossible,but the case was reopened 23 years later.By applying biogeochemical isotope methods to her body tissues,the geographical origin of the unknown corpse could be predicted.The results of the C,N,S,H,Sr,and Pb isotope analyses suggested that the female did not originate from Europe and most likely spent her youth in the northern Caribbean.Using these findings,the police were able to identify the woman within 2 weeks.The female came from the Dominican Republic and resided in Austria for only a short period before she was murdered.This case shows that isotope biogeochemistry investigations can provide the police with crucial information that enables unknown persons to be identified. | Christine Lehn Andreas Rossmann Matthias Graw Gareth R.Davies | 2022 | Forensic Sciences Research2022，7，2： | 0 |
| 10 | LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis显示文摘The factors that determine fibrosis progression or normal tissue repair are largely unknown.We previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(EMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine signaling.Here,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces EMT as a conse-quence.In IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 complex.3D co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augmented myofibroblast differentiation.Together,these data suggest that reduced autophagy caused by LKB1 inhibition can induce EMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk. | Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben G.Marshall David Hancock Tim Wallis Julian Downward Rob M.Ewing Donna E.Davies Mark G.Jones Yihua Wang | 2024 | Genes & Diseases2024，11，3： | 0 |
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