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| 1 | Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease显示文摘The search for biomarkers that characterize specific aspects of inflammatory bowel disease(IBD), has received substantial interest in the past years and is moving forward rapidly with the help of modern technologies. Nevertheless, there is a direct demand to identify adequate biomarkers for predicting and evaluating therapeutic response to different therapies. In this subset, pharmacogenetics deserves more attention as part of the endeavor to provide personalized medicine. The ultimate goal in this area is the adjustment of medication for a patient's specific genetic background and thereby to improve drug efficacy and safety rates. The aim of the following review is to utilize the latest knowledge on immunopathogenesis of IBD and update the findings on the field of Immunology and Genetics, to evaluate the response to the different therapies. In the present article, more than 400 publications were reviewed but finally 287 included based on design, reproducibility(or expectancy to be reproducible and translationable into humans) or already measured in humans. A few testshave shown clinical applicability. Other, i.e., genetic associations for the different therapies in IBD have not yet shown consistent or robust results. In the close future it is anticipated that this, cellular and genetic material, as well as the determination of biomarkers will be implemented in an integrated molecular diagnostic and prognostic approach to manage IBD patients. | Emilio G Quetglas Zlatan Mujagic Simone Wigge Daniel Keszthelyi Sebastian Wachten Ad Masclee Walter Reinisch | 2015 | World Journal of Gastroenterology2015，21，44： | 3 |
| 2 | SJGT14112700001344显示文摘 | Roser Pinyol Jean Nault Iris Quetglas Jessica Zucman-Rossi Josep Llovet | 2014 | Semin Liver Dis2014，，04： | 1 |
| 3 | Alphavirus vec-tors for cancer therapy显示文摘 | Quetglas J I Ruiz-Guillen M Aranda A | 2010 | Virus Research2010，153，2： | 1 |
| 4 | Bioequivalence of two oral formulationa of tri- flusal capsules in healthy volunteers 显示文摘 | QUETGLAS E G CAMPANERO M A SADABA B | 2008 | Arzneimittel- Forschung ( Drug Research)2008，58，6： | 1 |
| 5 | The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis显示文摘 | Bruno Hernáez Gema D??az-Gil Mónica Garc??a-Gallo José Ignacio Quetglas Ignacio Rodr??guez-Crespo Linda Dixon José M Escribano Covadonga Alonso | 2004 | FEBS Letters2004，，1： | 1 |
| 6 | Alphavirus vectors for cancer therapy显示文摘 | Jose I Quetglas Maria RuiGuillen Cristian Smerdou | 2010 | Virus Research2010，153，： | 1 |
| 7 | Alphavirus vectors fi~r cancer therapy显示文摘 | Quetglas J 1 Ruiz-Guillen M Aranda A | 2010 | Virus Res2010，153，2： | 1 |
| 8 | Length-weight relationship of fishes and cephalopods from the Balearic Islands (western Mediterranean),Naga显示文摘 | Merella P Quetglas A Alemany F | 1997 | ICLARM Quart1997，20，34： | 1 |
| 9 | Nuclear maturation kinetics and in vitro embryo development of cattle oocytes prematured with butyrolactone I combined or not combined with roscovitine显示文摘 | P.R. Adona P.R.L. Pires M.D. Quetglas K.R.L. Schwarz C.L.V. Leal | 2007 | Animal Reproduction Science2007，，2： | 1 |
| 10 | Virotherapy, gene transer and immunostimulalot7 monocltmal antibud- ies显示文摘 | Quetglas Jl John LB Kershaw Ml-l et aI | 2012 | Oncoimmunology2012，1，8： | 1 |
| 11 | Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis 显示文摘 | Quetglas S Iborra C Sasakawa N | 2002 | EMBO J2002，21，15： | 1 |
| 12 | Bioequiv- alence of two oral formulationa of triflusal capsules in healthy volunteers显示文摘 | Quetglas EG Campanero MA S~daba B | 2008 | Arzneimittelforschung2008，58，6： | 1 |
| 13 | Clinical rele vance of sirolimus drug interactions in transplant patients显示文摘 | Sadaba B Campanero MA Quetglas EG | 2004 | Transplant Proc2004，36，1： | 1 |
| 14 | Clinical relevance of sirolimus drug interactions in transplant patients显示文摘 | SADABA B CAMPANERO MA QUETGLAS EG | 2004 | Transplant Proc2004，36，10： | 1 |
| 15 | Bioequivalence of two oral formulations of triflusal capsules in healthy volunteers显示文摘 | Quetglas EG Campanero MA Sádaba B | 2008 | Arzneimittelforschung2008，58，6： | 1 |
| 16 | Demersal Continental Shelf and Upper Slope Cephalopod Assemblages from the Balearic Sea(North-Western Mediterranean):Biological Aspects of Some Deep-Sea Species显示文摘 | Quetglas A Carbonell A Sānchez P | 2000 | Estuarine Coastal and Shelf Science2000，50，： | 1 |
| 17 | Pharmaeokinet ics of tramadol enantiomers and their respective phase Ⅰ metabolites in relation to CYP2D6 phenotype显示文摘 | Garcia Quetglas E Azanza JR Sadaba B | 2007 | Pharmacol Res2007，55，2： | 1 |
| 18 | Bio- equivalence of two oral formulationa of triflusal capsules in health- y volunteers 显示文摘 | QUETGLAS EG CAMPANERO biA SADABA B | 2008 | Arznelmittel-Forschung ( Drug Research )2008，58，6： | 1 |
| 19 | Eradication of liver-implanted tumors by Semliki forest virus expressing IL-12 requires efficient long-term immune responses 显示文摘 | Quetglas JI Rodriguez-Madoz JR Bezunartea J | 2013 | J Immunol2013，190，6： | 1 |
| 20 | Simultaneous stereoselective analysis of tramadol and its primary phase I metabolites in plasma by liquid chromatography application to a pharmacokinetic study in humans显示文摘 | Campanero MA Quetglas EG Sadaba B | 2004 | J Chromatogr A2004，1031，12： | 1 |
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