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| 1 | Isolation, Identification and Pathogenicity Analysis of Streptococcus suis Type 2显示文摘[Objectives]This study aimed to investigate the pathogenicity,growth characteristics and drug resistance of Streptococcus suis type 2.[Methods]Bacterial isolation and identification,biochemical experiments,determination of growth curve and correlation curve between OD 600 values and viable counts,drug susceptibility tests,pathogenicity analysis,and histopathological observations were carried out.[Results]The Streptococcus strain isolated from infected pigs was identified as Streptococcus suis type 2,which was named TA01 strain.TA01 strain reached the growth peak at 6-8 h post-incubation,and viable counts gradually declined after 8 h of incubation.The correlation equation between OD 600 values and viable counts is y=24.659 x-1.076 1,R^2=0.996 7.TA01 strain was sensitive to penicillin,erythromycin,florfenicol and oxacillin,and resistant to ciprofloxacin,polymyxin B and clindamycin.According to the results of pathogenicity analysis,all the mice in 3.6×10^9 cfu/mouse group died within 48,and these dead mice exhibited acute pyaemia septica.Based on the Reed-Muench formula,it was calculated that LD 50 of TA01 strain was 1.137×10^8 cfu/mouse.Pathological examination showed obvious blue-stained bacteria clusters,accompanied by neutrophil infiltration.[Conclusions]TA01 strain was a virulent strain of Streptococcus suis type 2.Compared with Streptococcus strains which were isolated and reported in China,TA01 strain exhibited strong virulence and rapid proliferation. | Zicheng MA Yan LI Jinyuan GU Tao PENG Zhaohu LIU Hongyu WANG Fanliang MENG Fangkun WANG Sidang LIU | 2019 | Agricultural Biotechnology2019，8，4： | 3 |
| 2 | Least-Squares Mirrorsymmetric Solution for Matrix Equations(AX=B,XC=D)显示文摘In this paper, least-squaxes mirrorsymmetric solution for matrix equations (AX = B, XC = D) and its optimal approximation is considered. With special expression of mirrorsymmetric matrices, a general representation of solution for the least-squares problem is obtained. In addition, the optimal approximate solution and some algorithms to obtain the optimal approximation are provided. | Fanliang Li Xiyan Hu Lei Zhang | 2006 | Numerical Mathematics A Journal of Chinese Universities(English Series)2006，15，3： | 3 |
| 3 | The estimation-valued property of B-valued asymptotic martingale显示文摘在这篇论文,与珍视 B 的 asymptotic 鞅的 Doob 分解,我们在 Banach 空间 B 学习珍视 B 的 asymptotic 鞅的珍视评价的性质,它有 Radon-Nikodym 性质并且是双可分离的,并且给一系列结果和证明。 | KONG Fanliang | 2006 | Progress in Natural Science:Materials International2006，16，7： | 2 |
| 4 | Regulation of fruit ripening by the brassinosteroid biosynthetic gene SlCYP90B3 via an ethylenedependent pathway in tomato显示文摘The essential role of ethylene in fruit ripening has been thoroughly studied.However,the involvement of brassinosteroids(BRs)in the regulation of fruit ripening and their relationship with the ethylene pathway are poorly understood.In the current study,we found that BRs were actively synthesized during tomato fruit ripening.We then generated transgenic lines overexpressing or silencing SlCYP90B3,which encodes a cytochrome P450 monooxygenase that catalyzes the rate-limiting step of BR synthesis.The expression level of SlCYP90B3 was positively related to the contents of bioactive BRs as well as the ripening process in tomato fruit,including enhanced softening and increased soluble sugar and flavor volatile contents.Both carotenoid accumulation and ethylene production were strongly correlated with the expression level of SlCYP90B3,corroborated by the altered expression of carotenoid biosynthetic genes as well as ethylene pathway genes in transgenic tomato fruits.However,the application of the ethylene perception inhibitor 1-methycyclopropene(1-MCP)abolished the promotion effect of SlCYP90B3 overexpression on carotenoid accumulation.Taken together,these results increase our understanding of the involvement of SlCYP90B3 in bioactive BR biosynthesis as well as fruit ripening in tomato,thus making SlCYP90B3 a target gene for improvement of visual,nutritional and flavor qualities of tomato fruits with no yield penalty. | Songshen Hu Lihong Liu Shuo Li Zhiyong Shao Fanliang Meng Haoran Liu Wenyi Duan Dongyi Liang Changqing Zhu Tao Xu Qiaomei Wang | 2020 | Horticulture Research2020，7，1： | 2 |
| 5 | Poly(4-vinylpyridine) nanocrosslinked by polyhedral oligomeric silsesquioxane显示文摘 | Liu Yonghong Meng Fanliang Zheng Sixun | 2005 | Macromolecular Rapid Communication2005，26，11： | 1 |
| 6 | Least-squares mirrosymmetric solution for matrix equations (AX=B,XC=D) 显示文摘 | Li Fanliang Hu Xiyan Zhang Lei | 2006 | Numerical Mathematics: A Journal of Chinese Universities2006，15，3： | 1 |
| 7 | Mobility,miscibility,and microdomain structure in nanostructured thermoset blends of epoxy resin and amphiphilic poly(ethyleneoxide)-block-poly(propylene oxide)-blockpoly(ethylene oxide) triblock copolymers characterized by solid-state NMR显示文摘 | Fanliang Meng Sixun Zheng Tianxi Liu | 2005 | Macromolecules2005，，38： | 1 |
| 8 | Advance Research of Generalized Poisson Risk Model显示文摘 | KONG Fanliang XIN Hua | 2007 | Advances in Systems Science Application2007，12，2： | 1 |
| 9 | A Martingale Method of Optimization Design in Investment and Effectiveness Model显示文摘 | KONG Fanliang | 2007 | Advances in Systems Science Application2007，7，2： | 1 |
| 10 | Expression and Algorithm Implemention of Reliability for Complex System显示文摘 | Zhang Guozhi Liu Di Kong Fanliang | 2008 | Advances in Systems Science and Applications2008，8，3： | 1 |
| 11 | 锌指蛋白217基因表达与人卵巢癌细胞的关系(英文)显示文摘Objective: The aim of the study was to investigate the correlation of zinc-finger protein 217(ZNF217) gene expression with the biological behavior of human ovarian cancer HO-8910 cells. Methods: The expression of ZNF217 in ovarian carcinoma cell lines was detected by RT-PCR and Western blot, respectively. The biological behaviors of the transfectants were investigated by MTT, in vitro Boyden chamber and in vivo invasion assay, respectively. Results: RT-PCR and Western blotting revealed that transfection of ZNF217 into the HO-8910 cells significantly increased their proliferation along with markedly enhanced in vitro and in vivo invasion and metastatic abilities. MTT assay showed that the proliferation ability of p EGFPN1-ZNF217/HO-8910 cells was significantly higher than that of p EGFP-N1/HO-8910 cells and HO-8910 cells(P < 0.001). The Boyden chamber assay showed that the numbers of migrating p EGFP-N1-ZNF217/HO-8910, p EGFP-N1/ HO-8910 and HO-8910 cells were(141.25 ± 13.91) cells /200 × field,(82.50 ± 11.73) cells /200 × field and(81.75 ± 12.12) cells /200 × field, respectively, with a significant difference between them(F = 29.274, P < 0.001). The nude mouse experiment showed that the in vivo tumor formation ability of p EGFP-N1-ZNF217/HO-8910 cells was significantly higher than that of p EGFP-N1/HO-8910 cells(P < 0.001). Conclusion: Based on these clinical and laboratory observations, we conclude that ZNF217 may contribute to ovarian cancer invasion and metastasis, and associated with worse clinical outcomes. We evaluated ZNF217's role as a biomarker of ovarian carcinogenesis and tumor progression in patient samples and explored possible molecular mechanisms in promoting tumor growth and invasion. | Lilin Hang Min Zhang Fanliang Meng Mei Zhong Jing Li | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，11： | 1 |
| 12 | Nonlinear Theory and Method on the Forecast of the Short-term Climatic Process显示文摘 | KONG Fanliang | 2001 | Advances in Systems Science and Applications2001，，03： | 1 |
| 13 | The Forecast of the Epidemic Situation in the Dynamic System显示文摘 | KONG Fanliang | 1996 | Advances in Systems Science and Applications Special Issue1996，，1： | 1 |
| 14 | Successive projection iterative method for solving matrix equation AX: B 显示文摘 | Li Fanliang Gong Lisha Hu Xiyan | 2010 | Journal of Computational and Applied Mathematics2010，234，8： | 1 |
| 15 | Composition,categoryofnaturalasphaltanditstechnicalapplicabilityinpavement显示文摘 | FanLiang WangLin SongXiaojin etal | 2009 | JournalofBuiding Materials2009，12，3： | 1 |
| 16 | Ex-pression and Algorithm Implementation of Reliability for Complex System显示文摘 | ZHANG Guozhi LIU Di KONG Fanliang YANG Zhenhai | 2008 | Advances in Systems Science and Applications2008，8，4： | 1 |
| 17 | InfluenceofperformanceofmodifiedasphaltbynativerockGasphalt显示文摘 | FanLiang Shen Quanjun Zhang Yanyan | 2007 | JournalofBuidingMaterials2007，10，4： | 1 |
| 18 | Large eddy simulation of room fire spread using a medium scale compartment made of medium density fibreboard (MDF) panels显示文摘At present,there is a shortage of experimental and simulation studies on fire spread in medium-and large-scale compartments while the existing models of the fire spread are limited for typical engineering applications.This paper proposes a new model for large-scale fire spread on medium density fibreboard(MDF)panels.Validating the model with single burning item(SBI)experiments,it is found that the numerical simulation closely predicts the experimental heat release rate(HRR)with some error near the peak.The predicted heat flux and distance of lateral flame spread are consistent with the experiments and an existing model.The effects of kinetic properties and heat of combustion are identified through a sensitivity analysis.The decrease of activation energy and increase of pre-exponential factor make the MDF easier to pyrolyze and the increase of heat of combustion enhances the flame temperature and thus provide more heat feedback to the sample surface.The low activation energy(71.9 kJ/mol)and high heat of combustion(46.5 MJ/kg)of the model ensure the occurrence of flame spread.Furthermore,the model was validated using medium-scale compartment fire experiments and the results showed that the model can accurately predict the HRR after flashover(the error is within 7%).While the burner is ignited,the predictions of in-compartment gas temperature and heat flux are more accurate.However,when the burner is extinguished,the modelled in-compartment gas temperature is lower than the experimental values,resulting in a lower heat flux prediction.The model leads to easier flame spread;therefore,the modelled flame spreads faster in the compartment compared to the experiment,and thus the HRR increases more rapidly. | Jiayidaer Baolati Kaiyuan Li Yanyan Zou Kevin Frank George Hare Jiaqing Zhang Fanliang Ge | 2022 | Building Simulation2022，15，4： | 1 |
| 19 | Successive projection iterative method for solving matrix equation AX=B显示文摘 | Li Fanliang Gong Lisha H u Xiyan | 2010 | Jour- nal of Computational and Applied Mathematics2010，234，8： | 1 |
| 20 | Reciprocal interaction between vascular niche and sweat gland promotes sweat gland regeneration显示文摘The incorporation of vasculature is known to be effective in tissue or organ functional regeneration.However,a vague understanding of the interaction between epidermal appendages and their vascular niches is a foremost obstacle to obtaining sweat gland(SG)-specific vasculature units.Here,we map their precise anatomical con-nections and report that the interplay between SG cells(SGCs)and the surrounding vascular niche is key for glandular development and homeostasis maintenance.To replicate this interplay in vitro,we used three-dimensional(3D)bioprinting to generate reproducible SGC spheroids from differentiated adipose-derived mesenchymal stem cells(ADSCs).With dermal microvascular endothelial cells(DMECs),sacrificial templates made from poly(ε-caprolactone)(PCL)were fabricated to pattern the vascular niche.This interplay model promoted physiologically relevant vascularized glandular morphogenesis in vitro and in vivo.We identified a reciprocal regulatory mechanism for promoting SGs regeneration via contact-independent cell communication and direct cell-cell interactions between SGs and the vasculature.We envision the successful use of our approach for vascularized organ regeneration in the near future. | Xingyu Yuan Xianlan Duan Enhejirigala Zhao Li Bin Yao Wei Song Yuzhen Wang Yi Kong Shijun Zhu Fanliang Zhang Liting Liang Mengde Zhang Chao Zhang Deling Kong Meifeng Zhu Sha Huang Xiaobing Fu | 2023 | Bioactive Materials2023，，3： | 0 |
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