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| 1 | Decreased osteogenesis of adult mesenchymal stem cel s by reactive oxygen species under cyclic stretch: a possible mechanism of age related osteoporosis显示文摘Age related defect of the osteogenic differentiation of mesenchymal stem cells(MSCs) plays a key role in osteoporosis. Mechanical loading is one of the most important physical stimuli for osteoblast differentiation.Here, we compared the osteogenic potential of MSCs from young and adult rats under three rounds of 2 h of cyclic stretch of 2.5% elongation at 1 Hz on 3 consecutive days. Cyclic stretch induced a significant osteogenic differentiation of MSCs from young rats, while a compromised osteogenesis in MSCs from the adult rats.Accordingly, there were much more reactive oxygen species(ROS) production in adult MSCs under cyclic stretch compared to young MSCs. Moreover, ROS scavenger N-acetylcysteine rescued the osteogenic differentiation of adult MSCs under cyclic stretch. Gene expression analysis revealed that superoxide dismutase 1(SOD1) was significantly downregulated in those MSCs from adult rats. In summary, our data suggest that reduced SOD1 may result in excessive ROS production in adult MSCs under cyclic stretch, and thus manipulation of the MSCs from the adult donors with antioxidant would improve their osteogenic ability. | Jiali Tan Xin Xu Zhongchun Tong Jiong lin Qiujun Yu Yao Lin Wei Kuang | 2015 | Bone Research2015，3，1： | 15 |
| 2 | Characterization and Proteomic Analysis of Novel Rice Lesion Mimic Mutant with Enhanced Disease Resistance显示文摘Lesion mmic mutants(LMMs)are plants that spontaneously form lesions without pathogeninfection or external stimulus and exhibit resistance to pathogens.Here,a rice LMM was created by ethylmethane sulfonate mutagenesis,named as hpil(hydrogen peroxide induced lesion).Diaminobenzidineand trypan blue staining showed that large amounts of H_(2)O_(2) were produced and cell death was occurredat and around the parts of lesion mimic in the rice leaves.The phenotype of hpil is controlled by a singlerecessive gene,localized at a 2 Mb interval on chromosome 2.The data suggested that hpil is a novelLMM with enhanced bacterial and fungal disease resistance,and multiple pathogenesis-related proteins(PRs)were up-regulated.The proteomes of leaves at three positions(different degrees of lesion mimicseverity)were characterized in hpil compared with its wild type plant.Differentially expressed proteinswere detected by two dimensional difference gel electrophoresis and 274 proteins were identified byMALDITOF/TOFTM.These proteins were related to metabolic process,cellular process and response tostimulus,with mostly down-regulated in hpil leaves.Many of these proteins were related to the Calvincycle,photosynthetic electron transport chain,glycolysis/gluconeogenesis and phosphonates pathways.Some resistance-related proteins including 14-3-3 proteins,OsPR10 and antioxidases such asperoxidase,superoxide dismutase and ascorbate peroxidase were up-regulated in leaves with lesionmimic.These results provide the foundation for cloning of the target gene and shed light on themechanism involved in autaimmunity of rice. | Yang Yong Lin Qiujun Chen Xinyu Liang Weifang Fu Yuwen Xu Zhengjin Wu Yuanhua Wang Xuming Zhou Jie Yu Chulang Yan Chengqi Mei Qiong Chen Jianping | 2021 | Rice science2021，28，5： | 2 |
| 3 | An Aerothermal Study of Influence of Blockage Ratio on a Supersonic Tube Train System显示文摘Evacuated tube transportation is an important development direction for the high-speed transportation technology of the future.However,a train running at supersonic speed in a closed tube can create an unstable aerothermal phenomenon,causing the temperature to rise sharply inside the tube and endangering the safe operation of trains and equipment.The blockage ratio is one of the key factors affecting the aerodynamic characteristics in the tube.In this paper,a 2 D axisymmetric model and Delayed Detached Eddy Simulation(DDES)based on the Shear Stress Transport(SST)k-ωturbulence model are used to study the aerothermal environment in the tube.The calculation method used in this paper was verified by a wind tunnel experiment.The aerothermal phenomenon and distribution of the flow field in the tube with different blockage ratios were compared and analysed.The results show that the aerothermal environment is significantly affected by the blockage ratio.A choking limit formed in the flow field will aggravate the aerodynamic phenomenon as the blockage ratio increases,which further deteriorates the aerothermal environment of the tube.Moreover,the existence of the choking limit,shock wave,and Mach disk make the flow field in the tube more complicated. | SUI Yang NIU Jiqiang YUAN Yanping YU Qiujun CAO Xiaoling WU Dan YANG Xiaofeng | 2022 | Journal of Thermal Science2022，31，2： | 2 |
| 4 | A Novel Role for Survival in Insulin-induced Inhibition of Myocardial Apoptosis in Ischemic/reperfused Heart 显示文摘 | Rui Si Qiujun Yu Ning Zhou | 2008 | Circulation2008，118，2： | 1 |
| 5 | Spectroscopic analysis of the interaction between bilirubin and bovine serum albumin显示文摘 | Juan Chen Gongwu Song Yu He Qiujun Yan | 2007 | Microchimica Acta (-)2007，，1： | 1 |
| 6 | Aerodynamics of railway train/tunnel system:A review of recent research显示文摘The coupling and complexity of railway train/tunnel system are further aggravated by increasing train speed,which produces a series of aerodynamics problems,such as aerodynamic drag,slipstream,pressure wave and micro pressure wave.Aerodynamic effects of tunnels will result in a significant increase in train energy consump-tion,shorten life of railway train/tunnel system,and increase maintenance cost.This paper provides a review of aerodynamics of railway train/tunnel system.Challenges in railway train/tunnel system aerodynamics and their related factors are discussed firstly.Aerodynamic performance and flow field characteristics of trains in tunnels are presented.Relationship of aerodynamic effects and parameters of railway train/tunnel system,and the control methods for reducing aerodynamic effects in tunnels are explained.A traffic safety evaluation of the train in tunnels,such as vehicle body structure,passengers’ear comfort,etc.,is introduced and analysed.Finally,future outlooks and research topics are proposed. | Jiqiang Niu Yang Sui Qiujun Yu Xiaoling Cao Yanping Yuan | 2020 | Energy and Built Environment2020，1，4： | 1 |
| 7 | Cardiac-derived adiponectin induced by long-term insulin treatment ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic mice via AMPK signaling显示文摘 | Haifeng Pei Yan Qu Xiaoyan Lu Qiujun Yu Kun Lian Peilin Liu Wenjun Yan Jingyi Liu Yanzhuo Ma Yi Liu Chengxiang Li Weijie Li Wayne Bond Lau Haifeng Zhang Ling Tao | 2013 | Basic Research in Cardiology2013，，1： | 1 |
| 8 | Flow Characteristics and Aerodynamic Heating of Tube Trains in Choked/Unchoked Flow:A Numerical Study显示文摘Hyperloop has become one of the key reserve technologies for future high-speed rail transit.The gas in the tube is compressed and rubbed,leading to a strong aerodynamic heating effect.The research on the flow field characteristics and aerodynamic heating effect of hyperloop is in its infancy,and that on the flow field structure is lacking.In this study,the nozzle theory was used to make a preliminary judgment on the choked flow phenomenon in the hyperloop.Based on the flow results obtained under different working conditions,the identification basis of the choked flow phenomenon in the hyperloop was obtained.Furthermore,the effect of the choked/unchoked flow on the flow structure,temperature,and pressure distribution of the annular space in the tube was analyzed.Based on traditional high-speed railway aerodynamics,according to relevant theories and calculation in aerospace field,and combined with the model test data,the reliability verification analysis on the characteristics of the flow field are carried out.The structure of the flow filed in the tube can be divided into choked and unchoked.The judgment is dependent on whether the throat reaches the speed of sound.Under the choked flow,a normal shock wave is formed in front of the tube train.The temperature rise of the local flow field exceeds 50 K;the temperature rise of the stagnation region exceeds 88 K,and the pressure is approximately 1.7 times that of the initial pressure in the tube.When the flow is unchoked,differences arise in the distribution of the flow field corresponding to different incoming Mach numbers.When the incoming flow is supersonic,the flow field maintains a supersonic speed,and a bow-shaped shock wave is formed at the front of the tube train.Owing to the shock wave or expansion wave,the local flow field exhibits significant fluctuations in temperature and pressure.Conversely,when the incoming flow is subsonic,the flow field in the tube maintains a subsonic speed,and no shock wave structure is observed. | SUI Yang YU Qiujun NIU Jiqiang CAO Xiaoling YANG Xiaofeng YUAN Yanping | 2023 | Journal of Thermal Science2023，32，4： | 0 |
| 9 | TET1蛋白亚型转换调控DNA去甲基化和小鼠发育显示文摘文章简介DNA甲基化氧化酶TET蛋白在介导DNA去甲基化和调控个体发育中均起着非常重要的作用。但是,TET蛋白如何识别基因组中的催化位点仍然有待研究。本研究通过细致地观测转录组学数据,意外发现了TET蛋白家族成员TET1在小鼠不同发育时期中存在两个亚型。其中全长TET1亚型(TET1e)仅在小鼠早期胚胎、小鼠胚胎干细胞和原始生殖细胞中表达; | Wenhao Zhang Weikun Xia Qiujun Wang Aaron J Towers Jiayu Chen Rui Gao Yu Zhang Chia-an Yen Ah Young Lee Yuanyuan Li Chen Zhou Kaili Liu Jing Zhang Tian-Peng Gu Xiuqi Chen Zai Chang Danny Leung Shaorong Gao Yong-hui Jiang 颉伟 | 2017 | 科学新闻2017，19，4： | 0 |
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