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| 1 | New In-Situ LA-ICP-MS U-Pb Ages of Uraninite from the Mianhuakeng Uranium Deposit, Northern Guangdong Province, China: Constraint on the Metallogenic Mechanism显示文摘Objective Hydrothermal uranium deposits in South China have become one of the main uranium producers over the past several decades.Numerous uranium deposits are densely distributed in the Guidong and Zhuguangshan plutons of the Nanling region,which constitute the largest uranium mineralization area in China(Cai Yuqi et al.,2015).The Mianhuakeng(MHK)uranium deposit,one of the | ZHONG Fujun PAN Jiayong QI Jiaming YAN Jie LIU Wenquan LI Haidong | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 14 |
| 2 | Electrochemical performance of MCMB/(AC+LiFePO_4) lithium-ion capacitors显示文摘Lithium-ion capacitors(LICs) were fabricated using mesocarbon microbeads(MCMB) as a negative electrode and a mixture of activated carbon(AC) and LiFePO4 as a positive electrode(abbreviated as LAC).The phase structure and morphology of LAC samples were characterized by X-ray diffraction(XRD) and field emission scanning electron microscopy(FESEM).The electrochemical performance of the LICs was studied using cyclic voltammetry,charge-discharge rate measurements,and cycle performance testing.A LIC with 30 wt% LiFePO4 was found to have the best electrochemical performance with a specific energy density of 69.02 W h kg-1 remaining at 4 C rate after 100 cycles.Compared with an AC-only positive electrode system,the ratio of practical capacity to theoretical calculated capacity of the LICs was enhanced from 42.22% to 56.59%.It was proved that adding LiFePO4 to AC electrodes not only increased the capacity of the positive electrode,but also improved the electrochemical performances of the whole LICs via Li+ pre-doping. | PING LiNa ZHENG JiaMing SHI ZhiQiang QI Jie WANG ChengYang | 2013 | Chinese Science Bulletin2013，58，6： | 12 |
| 3 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 4 | Single-nucleus transcriptomic landscape of primate hippocampal aging显示文摘The hippocampus plays a crucial role in learning and memory,and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases.Yet a systematic profiling of the aging effects on various hippocampal cell types in primates is still missing.Here,we reported a variety of new aging-associated phenotypic changes of the primate hippocampus.These include,in particular,increased DNA damage and heterochromatin erosion with time,alongside loss of proteostasis and elevated inflammation.To understand their cellular and molecular causes,we established the first single-nucleus transcriptomic atlas of primate hippocampal aging.Among the 12 identified cell types,neural transiently amplifying progenitor cell(TAPC)and microglia were most affected by aging.In-depth dissection of gene-expression dynamics revealed impaired TAPC division and compromised neuronal function along the neurogenesis trajectory;additionally elevated pro-inflammatory responses in the aged microglia and oligodendrocyte,as well as dysregulated coagulation pathways in the aged endothelial cells may contribute to a hostile microenvironment for neurogenesis.This rich resource for understanding primate hippocampal aging may provide potential diagnostic biomarkers and therapeutic interventions against age-related neurodegenerative diseases. | Hui Zhang Jiaming Li Jie Ren Shuhui Sun Shuai Ma Weiqi Zhang Yang Yu Yusheng Cai Kaowen Yan Wei Li Baoyang Hu Piu Chan Guo-Guang Zhao Juan Carlos Izpisua Belmonte Qi Zhou Jing Qu Si Wang Guang-Hui Liu | 2021 | Protein & Cell2021，12，9： | 5 |
| 5 | The Variation of Stone Cell Content in 236 Germplasms of Sand Pear(Pyrus pyrifolia)and Identification of Related Candidate Genes显示文摘Stone cells have been described to substantially influence pear fruit quality,as lignin and cellulose are the main components of stone cells.However,there are limited studies on the relationship between the variation and molecular basis of stone cells,lignin and cellulose content among different pear varieties.Here,to reveal the variation of stone cell content within different cultivated species,we collected 236 germplasms of sand pear(Pyrus pyrifolia)at 50 days after flower blooming(DAFB),the key stage of stone cell formation.In our results,we measured the content of stone cells,lignin and cellulose and found that these contents ranged from2.82%to 29.00%,8.84%to 55.30%and 11.52%to 30.55%,respectively.Further analysis showed that the variation coefficient of stone cell,lignin and cellulose content was 39.10%,28.03%and 16.71%,respectively.Additionally,a significant correlation between stone cell,lignin and cellulose content were detected,and the correlation coefficient between the contents of stone cell and lignin(0.912)was higher than between the contents of stone cell and cellulose(0.796).Moreover,the average lignin content(29.73%)was higher than the average cellulose content(18.03%)in stone cells in pear fruits,indicating that lignin is the main component of stone cell in pears.Finally,on the basic of the transcriptome data,we identified 10 transcription factors belonging to bHLH,ERF,MYB,and NAC transcript families,which might be involved in lignin formation in stone cells.qRT-PCR experiments verified coincident trends between expression of candidate genes and stone cell content.This research laid foundation for future studies on genetic variation of stone cells in pear fruits and provided important gene resources for stone cell regulation. | Jiaying Zhang Jiaming Li Cheng Xue Runze Wang Mingyue Zhang Kaijie Qi Jing Fan Hongju Hu Shaoling Zhang Jun Wu | 2021 | Horticultural Plant Journal2021，7，2： | 3 |
| 6 | Effect of Zr on phase separation,mechanical and corrosion behavior of heterogeneous CoCrFeNiZr_(x) high-etropy alloy显示文摘CoCrFeNi high entropy alloy(HEA)has attracted extensive attention due to its excellent corrosion resistance,but the low strength limits its engineering application prospects.In order to develop CoCrFeNi based HEAs with high strength,ductility and corrosion resistance,the effects of Zr content on the microstructure,mechanical properties and corrosion resistance of heterogeneous CoCrFeNiZr_(x)(x=0,0.25,0.5 and 1)HEAs were investigated in this work.The results indicate that the increase of Zr content can significantly affect the phase stability of the alloy,and promote the formation of intermetallic compounds(Ni_(7)Zr_(2)and/or Laves phase)and the transformation of solid solution from face-centered cubic(FCC)structure(x=0,0.25 and 0.5)to body-centered cubic(BCC)structure(x=1).Reasonable control of the Zr content can endow the alloy excellent comprehensive properties.Especially,for CoCrFeNiZr_(0.25) alloy,composed of FCC matrix and a small amount of Ni_(7)Zr_(2)phases,the yield strength(~655 MPa)is increased by nearly four times higher than that of Zr-free alloy,and it also has good ductility(fracture stain>50%).Meanwhile,the corrosion resistance of CoCrFeNiZr_(0.25) alloy is better than that of SS304.The EIS results show that the addition of Zr reduces the stability of the passive film on the alloy,which can be related to the content of the beneficial oxide in the passive film and the thickness of the passive film through XPS analysis.Moreover,the work functions of different phases in CoCrFeNiZr_(x)alloys were obtained by firstprinciples calculations,which further confirmed the selective corrosion mechanism of the CoCrFeNiZr_(x) alloy combining the experimental results. | Wu Qi Wenrui Wang Xiao Yang Lu Xie Jiaming Zhang Dongyue Li Yong Zhang | 2022 | Journal of Materials Science & Technology2022，，14： | 3 |
| 7 | Nigral degeneration with inclusionbody formation and behavioral changes in rats after proteasomal inhibition显示文摘 | Chaoshi Niu Jiaming Mei Qi Pan | 2009 | Stereotact Funct Neurosurg2009，87，： | 1 |
| 8 | Experimental investigation of Z-pinch radiation source for indirect drive inertial confinement fusion显示文摘Z-pinch dynamic hohlraums(ZPDHs)could potentially be used to drive inertial confinement fusion targets.Double-or multishell capsules using the technique of volume ignition could exploit the advantages of ZPDHs while tolerating their radiation asymmetry,which would be unacceptable for a central ignition target.In this paper,we review research on Z-pinch implosions and ZPDHs for indirect drive targets at the Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics.The characteristics of double-shell targets and the associated technical requirements are analyzed through a one-dimensional computer code developed from MULTI-IFE.Some key issues regarding the establishment of suitable sources for dynamic hohlraums are introduced,such as soft X-ray power optimization,novel methods for plasma profile modulation,and the use of thin-shell liner implosions to inhibit the generation of prior-stagnated plasma.Finally,shock propagation and radiation characteristics in a ZPDH are presented and discussed,together with some plans for future work. | Zhenghong Li Zhen Wang Rongkun Xu Jianlun Yang Fan Ye Yanyun Chu Zeping Xu Faxin Chen Shijian Meng Jianmin Qi Qinyuan Hu Yi Qin Jiaming Ning Zhanchang Huang Linbo Li Shuqing Jiang | 2019 | Matter and Radiation at Extremes2019，4，4： | 1 |
| 9 | Fiber dispersion and nonlinearity influences on transmissions of AM and FM data modulation signals in radio-over-fiber system显示文摘 | Xiaoqiong Qi Jiaming Liu Xiaoping Zhang | | 0，，08： | 1 |
| 10 | Identification of Telmisartan as a Unique Angiotensin II: Receptor Antagonist With Selective PPARγ–Modulating Activity显示文摘 | Stephen C. Benson Harrihar A. Pershadsingh Christopher I. Ho Amar Chittiboyina Prashant Desai Michal Pravenec Nianning Qi Jiaming Wang Mitchell A. Avery Theodore W. Kurtz | 2004 | Hypertension: Journal of the American Heart Association2004，，5： | 1 |
| 11 | Identification of Telmisartan as a Unique Angiotensin II: Receptor Antagonist With Selective PPARγ–Modulating Activity显示文摘 | Stephen C. Benson Harrihar A. Pershadsingh Christopher I. Ho Amar Chittiboyina Prashant Desai Michal Pravenec Nianning Qi Jiaming Wang Mitchell A. Avery Theodore W. Kurtz | 2004 | Hypertension: Journal of the American Heart Association2004，，5： | 1 |
| 12 | Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition显示文摘 | Chaoshi Niu Jiaming Mei Qi Pan | 2009 | Stereo - tact Funct Neurosurg2009，87，2： | 1 |
| 13 | Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins显示文摘The emergence of SARS-CoV-2 has resulted in the COVID-19 pandemic,leading to millions of infections and hundreds of thousands of human deaths.The efficient replication and population spread of SARS-CoV-2 indicates an effective evasion of human innate immune responses,although the viral proteins responsible for this immune evasion are not clear.In this study,we identified SARS-CoV-2 structural proteins,accessory proteins,and the main viral protease as potent inhibitors of host innate immune responses of distinct pathways.In particular,the main viral protease was a potent inhibitor of both the RLR and cGAS-STING pathways.Viral accessory protein 0RF3a had the unique ability to inhibit STING,but not the RLR response.On the other hand,structural protein N was a unique RLR inhibitor.0RF3a bound STING in a unique fashion and blocked the nuclear accumulation of p65 to inhibit nuclear factor-KB signaling.3CL of SARS-CoV-2 inhibited K63-ubiquitin modification of STING to disrupt the assembly of the STING functional complex and downstream signaling.Diverse vertebrate STINGs,including those from humans,mice,and chickens,could be inhibited by 0RF3a and 3CL of SARS-CoV-2.The existence of more effective innate immune suppressors in pathogenic coronaviruses may allow them to replicate more efficiently in vivo.Since evasion of host innate immune responses is essential for the survival of all viruses,our study provides insights into the design of therapeutic agents against SARS-CoV-2. | Yajuan Rui Jiaming Su Si Shen Ying Hu Dingbo Huang Wenwen Zheng Meng Lou Yifei Shi Meng Wang Shiqi Chen Na Zhao Qi Dong Yong Cai Rongzhen Xu Shu Zheng Xiao-Fang Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 1 |
| 14 | Micromotor-derived composites for biomedicine delivery and other related purposes显示文摘Biocompatible designed micromotor has attracted more and more concerns in the field of biomedicine due to their self-propulsion and delivery abilities.Such micromotors,mostly consisting of alkali earth metals,hydrogels,or other motile biomaterials,can effectively transform chemical energy into mechanical or kinetic energy to achieve the expected delivery of cargos to the sites of action.Except for conveying power,the modifiable surface and inner cavity of micromotors guarantee that their potential as versatile delivery systems for therapeutic agents.Here,this review generalizes the propelling mechanisms,composites,and shapes of micromotors.Besides,the application of micromotor-derived composites for biomedicine delivery and other versatile purposes are also discussed. | Xiang Xu Zhiyi Huo Jiaming Guo Hao Liu Xiaole Qi Zhenghong Wu | 2020 | Bio-Design and Manufacturing2020，3，2： | 1 |
| 15 | Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway显示文摘Liver is an important organ for regulating glucose and lipid metabolism.Recent studies have shown that bone morphogenetic proteins(BMPs)may play important roles in regu-lating glucose and lipid metabolism.Inour previous studies,we demonstrated that BMP4 signif-icantly inhibits hepatic steatosis and lowers serum triglycerides,playing a protective role against the progression of non-alcoholic fatty liver disease(NAFLD).However,the direct impact of BMP4 on hepatic glucose metabolism is poorly understood.Here,we investigated the regulatory roles of BMP4 in hepatic glucose metabolism.Through a comprehensive analysis of the 14 types of BMPs,we found that BMP4 was one of the most potent BMPs in promoting hepatic glycogen accumulation,reducing the level of glucose in hepatocytes and effecting the expression of genes related to glucose metabolism.Mechanistically,we demonstrated that BMP4 reduced the hepatic glucose lewels through the activation of mTORC2 signaling pathway in vitro and in wivo.Collectively,our findings strongly suggest that BMP4 may play an essential role in regulating hepatic glucose metabolism.This knowledge should aid us to understand the molecular pathogenesis of NAFLD,and may lead to the development of novel therapeutics by exploiting the inhibitory effects of BMPs on hepatic glucose and lipid metabolism. | Liqin An Qiong Shi Ying Zhu Hao Wang Qi Peng Jinghong Wu Yu Cheng Wei Zhang Yanyu Yi Zihao Bao Hui Zhang Yetao Luo Jiaming Fan | 2021 | Genes & Diseases2021，8，4： | 1 |
| 16 | Fault Diagnosis of Industrial Motors with Extremely Similar Thermal Images Based on Deep Learning-Related Classification Approaches显示文摘Induction motors(IMs)typically fail due to the rate of stator short-circuits.Because of the similarity of the thermal images produced by various instances of short-circuit and the minor interclass distinctions between categories,non-destructive fault detection is universally perceived as a difficult issue.This paper adopts the deep learning model combined with feature fusion methods based on the image’s low-level features with higher resolution and more position and details and high-level features with more semantic information to develop a high-accuracy classification-detection approach for the fault diagnosis of IMs.Based on the publicly available thermal images(IRT)dataset related to condition monitoring of electrical equipment-IMs,the proposed approach outperforms the highest training accuracy,validation accuracy,and testing accuracy,i.e.,99%,100%,and 94%,respectively,compared with 8 benchmark approaches based on deep learning models and 3 existing approaches in the literature for 11-class IMs faults.Even the training loss,validation loss,and testing loss of the eleven deployed deep learning models meet industry standards. | Hong Zhang Qi Wang Lixing Chen Jiaming Zhou Haijian Shao | 2023 | Energy Engineering2023，120，8： | 0 |
| 17 | Genomic selection of eight fruit traits in pear显示文摘Genomic selection (GS) has the potential to improve selection efficiency and shorten the breeding cycle in fruit tree breeding. In this study,we evaluated the effect of prediction methods, marker density and the training population (TP) size on pear GS for improving its performance and reducing cost. We evaluated GS under two scenarios:(1) five-fold cross-validation in an interspecific pear family;(2) independent validation. Based on the cross-validation scheme, the prediction accuracy (PA) of eight fruit traits varied between 0.33 (fruit core vertical diameter)and 0.65 (stone cell content). Except for single fruit weight, a slightly better prediction accuracy (PA) was observed for the five parametrical methods compared with the two non-parametrical methods. In our TP of 310 individuals, 2 000 single nucleotide polymorphism (SNP) markers were sufficient to make reasonably accurate predictions. PAs for different traits increased by 18.21%-46.98%when the TP size increased from 50to 100, but the increment was smaller (-4.13%-33.91%) when the TP size increased from 200 to 250. For independent validation, the PAs ranged from 0.11 to 0.45 using rrBLUP method. In summary, our results showed that the TP size and SNP numbers had a greater impact on the PA than prediction methods. Furthermore, relatedness among the training and validation sets, and the complexity of traits should be considered when designing a TP to predict the test panel. | Manyi Sun Mingyue Zhang Satish Kumar Mengfan Qin Yueyuan Liu Runze Wang Kaijie Qi Shaoling Zhang Wenjing Chang Jiaming Li Jun Wu | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 18 | Large photovoltaic effect with ultrahigh open-circuit voltage in relaxor-based ferroelectric Pb(In_(1/2)Nb_(1/2))O_(3)-Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)ceramics显示文摘Recently,the anomalous photovoltaic effect of ferroelectric materials has attracted considerable attention in the construction of efficient solar cells owing to the above-bandgap photovoltage of these materials.In this study,we investigate the anomalous photovoltaic effect of relaxor-based ferroelectric Pb(In_(1/2)Nb_(1/2))O_(3)-Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)(PIMN-PT)ceramics with large remnant polarization and a narrow optical bandgap.Excellent photovoltaic performance with an ultrahigh open-circuit voltage of 23 V(575 V/cm)is achieved,which is higher than the open-circuit voltages of all reported polycrystalline materials with similar thickness.The phase structure,microstructure morphology,domain structure,ferroelectric and optical characteristics are analyzed,which could provide clues to the origin of the ultrahigh open-circuit voltage of PIMN-PT ceramics.The results suggest that the relaxor-based ferroelectric PIMNPT system is a potential candidate for photovoltaic solar energy conversion devices. | Xudong Qi Kai Li Enwei Sun Bingqian Song Da Huo Jiaming Li Xianjie Wang Rui Zhang Bin Yang Wenwu Cao | 2022 | Journal of Materials Science & Technology2022，，9： | 0 |
| 19 | Passive attitude stabilization of ionic-wind-powered micro air vehicles显示文摘The ionic-wind-powered Micro Air Vehicles(MAVs)can achieve a higher thrust-toweight ratio than other MAVs.However,this kind of MAV has not yet achieved controlled flight because of the unstable thrust produced by the ionic wind and the dynamic instability related to the small size.In this paper,a passive attitude stabilization method of the ionic-wind-powered MAV using air dampers is introduced.The key factors that influence the performance of the air dampers,including the layout,position,and area of the air dampers,are theoretically studied.The appropriate optimal position of the air dampers is also obtained by Monte Carlo stochastic simulations.Then the proposed passive attitude stabilization method is applied to the ionic-wind-powered MAVs of different wingspan(2 cm and 6.3 cm).Finally,the experimental results show that using the proposed method,attitude stabilization is achieved for the first time for the ionic-wind-powered MAV.Moreover,the altitude control of an ionic-wind-powered MAV with a wingspan of 6.3 cm is also demonstrated. | Hengyu ZHANG Jiaming LENG Zhiwei LIU Mingjing QI Xiaojun YAN | 2023 | Chinese Journal of Aeronautics2023，36，7： | 0 |
| 20 | Trilayered Fibrous Dressing with Wettability Gradient for Spontaneous and Directional Transport of Massive Exudate and Wound Healing Promotion显示文摘Excessive exudate at wound sites increases treatment difficulty and severely decelerates the healing process.In wound exu-date management,dressings with unidirectional liquid transport capability have exhibited enormous potential.However,it remains challenging to improve the one-way liquid transport efficiency.Herein,a trilayered fibrous dressing is constructed by sequentially electrospinning polyurethane(PU)and polyvinylidene fluoride(PVDF)onto cotton fabric.Through hot pressing,a stable wettability gradient is formed across the PVDF/PU/cotton dressing due to the melting and bridging of PU nanofib-ers.The trilayered dressing exhibited rapid unidirectional transport with water penetrating from the hydrophobic side to the hydrophilic side in 6 s.The hydrostatic pressure from the hydrophilic side to the hydrophobic side is 569%higher than that from the hydrophobic side to the hydrophilic side,indicating that the dressing has a profound unidirectional conductivity.In vivo experiments demonstrates that the trilayered dressing can accelerate the wound healing process,especially in the early stages of wound occurrence,by quickly draining the excessive exudate.This study provides a new method to construct wound dressings with wettability gradients,which are advantageous for efficient exudate removal. | Lei Liu Hengqiu Sun Jiaming Zhang Bingjie Xu Yujie Gao Dongming Qi Zhengwei Mao Jindan Wu | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
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