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| 1 | Mechanism of diarrhea in microscopic colitis显示文摘AIM: To search the pathophysiological mechanism of diarrhea based on daily stool weights, fecal electrolytes,osmotic gap and pH.METHODS: Seventy-six patients were included: 51 with microscopic colitis (MC) [40 with lymphocytic colitis (LC);11 with collagenous colitis (CC)]; 7 with MC without diarrhea and 18 as a control group (CG). They collected stool for 3 d. Sodium and potassium concentration were determined by flame photometry and chloride concentration by titration method of Schales. Fecal osmotic gap was calculated from the difference of osmolarity of fecal fluid and double sum of sodium and potassium concentration.RESULTS: Fecal fluid sodium concentration was significantly increased in LC 58.11±5.38 mmol/L (P<0.01)and CC 54.14±8.42 mmol/L (P<0.05) than in CG 34.28±2.98 mmol/L. Potassium concentration in LC 74.65±5.29 mmol/L (P<0.01) and CC 75.53±8.78 mmol/L (P<0.05) was significantly less compared to CG 92.67±2.99 mmol/L.Chloride concentration in CC 36.07±7.29 mmol/L was significantly higher than in CG 24.11±2.05 mmol/L (P<0.05).Forty-four (86.7%) patients had a secretory diarrhea compared to fecal osmotic gap. Seven (13.3%) patients had osmotic diarrhea.CONCLUSION: Diarrhea in MC mostly belongs to the secretory type. The major pathophysiological mechanism in LC could be explained by a decrease of active sodium absorption. In CC, decreased Cl/HCO3 exchange rate and increased chloride secretion are coexistent pathways. | Marijana Protic Njegica Jojic Daniela Bojic Svetlana Milutinovic Dusanka Necic Bozidar Bojic Petar Svorcan Miodrag Krstic Obren Popovic | 2005 | World Journal of Gastroenterology2005，11，35： | 5 |
| 2 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 3 | The Role of Potassium Channels in the VasodilatationInducedby Resvera- trol and Naringenin in Isolated Human Umbilical Vein 显示文摘 | Protic Dragana R Nebojsa S Svetlana | 2015 | Drug Development Research2015，76，1： | 1 |
| 4 | Proliferating cell nuclear antigen (PCNA): ringmaster of the genome 显示文摘 | Paunesku T Mittal S Protic M | 2001 | Int J Radiat Biol2001，77，10： | 1 |
| 5 | Uterine Leiomyoma : Available Medical Treatments and New Possible Therapeutic Options 显示文摘 | Islam MS Protic O Giannubilo SR | 2013 | Clin Endocrinol Metab2013，98，3： | 1 |
| 6 | Postoperative complications and overall survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma显示文摘 | Pugalenthi A Protic M Gonen M | 2016 | J Surg Oncol2016，113，2： | 1 |
| 7 | Uterine leiomyoma:available medical treatments and new possible therapeutic options显示文摘 | Islam MS Protic O Giannubilo SR | 2013 | J Clin Endocrinol Metab2013，98，3： | 1 |
| 8 | The pattern and outcome of acute severe colitis显示文摘 | Lotte C. Dinesen Alissa J. Walsh Marijana Nedeljkovic Protic Graham Heap Fraser Cummings Bryan F. Warren Bruce George Neil J.M. Mortensen Simon P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，： | 1 |
| 9 | Application of topological indices to gas chromatographic data: calculation of the retention indices of isomeric alkylbenzenes 显示文摘 | BONCHEV D MEKENJAN O PROTIC G | 1979 | J Chromatogr1979，176，： | 1 |
| 10 | Uterine leiomyoma: available medical treatments and new possible therapeutic options显示文摘 | Islam MS Protic 0 Giannubilo SR | 2013 | 1 Clin Endocrinol Metab2013，98，3： | 1 |
| 11 | Uterine leiomyoma: available medical treatments and new possible therapeutic options显示文摘 | Islam MS Protic O Giannubilo SR | 2013 | J Clin Endocrinol Metab2013，98，3： | 1 |
| 12 | Uterine leiomyoma: available medical treatments and new possible therapeutic op- tions 显示文摘 | Islam M S Protic O Giannubilo S R | 2013 | J Clin Endocrinol Metab2013，98，3： | 1 |
| 13 | Complex networks of multiple factors in the pathogenesis of uterine leiomyoma显示文摘 | Islam MS Protic O Stortoni P | 2013 | Fertil Steril2013，100，1： | 1 |
| 14 | Some congruences on a r- Regular semigroups显示文摘 | Protic P V | 1990 | Facta University ser Math Inform1990，5，： | 1 |
| 15 | Uterine leiomyoma: available medical treatments and new possible therapeutic options 显示文摘 | Islam MS Protic O Giannubilo SR | 2013 | J Clin Endocrinol Metab2013，98，3： | 1 |
| 16 | Complex networks of multi- ple factors in the pathogenesis of uterine leiomyoma显示文摘 | Islam MS Protic O Stortoni P | 2013 | Fertil Steril2013，100，1： | 1 |
| 17 | Complex networks of multiple factors in the pathogenesis of uterine leiomyoma 显示文摘 | Islam MS Protic O Stortoni P | 2013 | Fertil Steril2013，100，1： | 1 |
| 18 | Proliferating cell nuclear antigen (PCNA):ringmaster of the genome显示文摘 | Paunesku T Mittal S Protic M | 2001 | Int J Radiat Biol2001，77，10： | 1 |
| 19 | Purification of an Ultraviolet-inducible, Damage-specific DNA-binding Protein from Primate Cells 显示文摘 | Abramic M Levine A Protic M | 1991 | Jounal of Biological Chemistry1991，266，22： | 1 |
| 20 | Sensitivity to low-level radiation in radiosensitive 'wasted' mice 显示文摘 | Woloschak GE Paunesku T Protic M | 2002 | Mil Med2002，167，2： | 1 |
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