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28篇 您的检索式:作者名="Protic M"
    题名 作者 年代 出处 被引量
1Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients.Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein 2017World Journal of Gastroenterology2017,23,16:3
2Proliferating cell nuclear antigen (PCNA): ringmaster of the genome 显示文摘Paunesku T Mittal S Protic M 2001Int J Radiat Biol2001,77,10:1
3Postoperative complications and overall survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma显示文摘Pugalenthi A Protic M Gonen M 2016J Surg Oncol2016,113,2:1
4Uterine leiomyoma: available medical treatments and new possible therapeutic op- tions 显示文摘Islam M S Protic O Giannubilo S R 2013J Clin Endocrinol Metab2013,98,3:1
5Proliferating cell nuclear antigen (PCNA):ringmaster of the genome显示文摘Paunesku T Mittal S Protic M 2001Int J Radiat Biol2001,77,10:1
6Purification of an Ultraviolet-inducible, Damage-specific DNA-binding Protein from Primate Cells 显示文摘Abramic M Levine A Protic M 1991Jounal of Biological Chemistry1991,266,22:1
7Sensitivity to low-level radiation in radiosensitive 'wasted' mice 显示文摘Woloschak GE Paunesku T Protic M 2002Mil Med2002,167,2:1
8Postoperative complicationsand overall survival after pancreaticoduodenectomy for pancreaticductal adenocarcinoma显示文摘Pugalenthi A Protic M Gonen M 2016J Surg Oncol2016,113,2:1
9Proliferating cell nuclear antigen (PCNA):ringmaster of the genome显示文摘Paunesku T Mittal S Protic M 2001Int J Radiat Biol2001,77,10:1
10Distributed shared memory: concepts and systems 显示文摘Protic J Tomasevic M Milutinovic V 1996Parallel and Distributed Technology : Systems and Applications1996,4,2:1
11Uterine leiomyoma: available medical treatments and new possible therapeutic options显示文摘Islam M S Protic O Giannubilo S R 2013Clin Endocrinol Metab2013,98,3:1
12Proliferating cell nuclear antigen (PCNA):ringmaster of the genome显示文摘Paunesku T Mittal S Protic M 2001Int J Radiat Biol2001,77,10:1
13Proliferating cell nuclear antigen(PCNA):riognaster of the genome显示文摘Paunesku T Mittal S Protic M 2001Int J Radiat Biol2001,77,10:1
14Molecular connectivity: a novel method for prediction of bioconcentration factor of hazardous chemicals显示文摘Sabljic A Protic M 1982Chem Biol Interaction1982,42,3:1
15Proliferating cell nuclear antigen (PCNA): ringmaster of the genome 显示文摘Paunesku T Mittal S Protic M 2001Int J Radiat Biol2001,77,10:1
16Prospective clinical trial of factors predicting the early development of incisional hernia after midline laparotomy显示文摘Veljkovic R Protic M Gluhovic A 2010J Am Coll Surg2010,210,:1
17Molecular connectivity: a novel method for prediction of bioconcentration factor of hazardous chemicals 显示文摘SABLJIC A PROTIC M 1982Chemico Biological Interactions1982,42,:1
18Response of heteroge-neous ribonuclear proteins(hnRNP) to ionising radiation and their involvement in DNA damage repair显示文摘HALEY B PAUNESKU T PROTIC M 0,,08:1
19Complex net- works of multiple factors in the pathogenesis of uterine leiomy- oma 显示文摘ISLAM M S PROTIC O STORTONI P 2013Fertility and Sterility2013,100,1:1
20Uterine leiomyo- ma:available medical treatments and new possible therapeu- tic options 显示文摘Islam M S Protic O Giannubilo S R 2013The Journal of Clinical Endocrinology&Metabolism2013,98,3:1
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