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| 1 | Chikungunya virus,epidemiology,clinics and phylogenesis:A review显示文摘Chikungunva virus is a mosquito-transmitted alphavirus that causes chikungunva fever,a febrile illness associated with severe arthralgia and rash.Chikungunva virus is transmitted by culicine mosquitoes:Chikungunya virus replicates in the skin,disseminates to liver,muscle,joints.lymphoid tissue and brain,presumably through the blood.Phylogenetic studies showed that the Indian Ocean and the Indian subcontinent epidemics were caused by two different introductions of distinct strains of East/Central/South African genotype of CHIKV.The paraphyletic grouping of African CHIK viruses supports the historical evidence that the virus was introduced into Asia from Africa.Phylogenetic analysis divided Chikungunva virus isolates into three distinct genotypes based on geographical origins:the first,the West Africa genotype,consisted of isolates from Senegal and Nigeria;the second contained strains from East/Central/South African genotype,while the third contained solely Asian.The most recent common ancestor for the recent epidemic,which ravaged Indian Ocean islands and Indian subcontinent in 2004- 2007.was found to date in 2002.Asian lineage dated about 1952 and exhibits similar spread patterns of the recent Indian Ocean outbreak lineage,with successive epidemics detected along an eastward path.Asian group splitted into two clades:an Indian lineage and a south east lineage.Outbreaks of Chikungunya virus fever in Asia have not been associated necessarily with outbreaks in Africa.Phylogenetic tools can reconstruct geographic spread of Chikungunva virus during the epidemics wave.The good management of patients with acute Chikungunva virus infection is essential for public health in susceptible areas with current Aedes spp activity. | Alessandra Lo Presti Alessia Lai Eleonora Cella Gianguglielmo Zehender Massimo Ciccozzi | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，12： | 8 |
| 2 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 3 | Molecular epidemiology and phylogeny of Nipah virus infection:A mini review显示文摘Nipah virus(Ni V) is a member of the genus Henipavirus of the family Paramyxoviridae,characterized by high pathogenicity and endemic in South Asia.It is classified as a Biosafety Level-4(BSL-4) agent.The case-fatality varies from 40%-70% depending on the severity of the disease and on the availability of adequate healthcare facilities.At present no antiviral drugs are available for Ni V disease and the treatment is just supportive.Phylogenetic and evolutionary analyses can be used to help in understanding the epidemiology and the temporal origin of this virus.This review provides an overview of evolutionary studies performed on Nipah viruses circulating in different countries.Thirty phylogenetic studies have been published from 2000 to 2015 years,searching on pub-med using the key words ‘Nipah virus AND phylogeny' and twenty-eight molecular epidemiological studies from 2006 to 2015 have been performed,typing the key words ‘Nipah virus AND molecular epidemiology'.Overall data from the published study demonstrated as phylogenetic and evolutionary analysis represent promising tools to evidence NiV epidemics,to study their origin and evolution and finally to act with effective preventive measure. | Silvia Angeletti Alessandra Lo Presti Eleonora Cella Massimo Ciccozzi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，7： | 4 |
| 4 | Enigmatic origin of hepatitis B virus:An ancient travelling companion or a recent encounter?显示文摘Hepatitis B virus(HBV)is the leading cause of liver disease and infects an estimated 240 million people worldwide.It is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral replication.The ten genotypes(A-J)that have been described so far further segregate into a number of subgenotypes which have distinct ethno-geographic distribution.Genotypes A and D are ubiquitous and the most prevalent genotypes in Europe(mainly represented by subgenotypes D1-3 and A2);genotypes B and C are restricted to eastern Asia and Oceania;genotype E to central and western Africa;and genotypes H and F(classified into 4 subgenotypes)to Latin America and Alaska.This review summarises the data obtained by studying the global phylodynamics and phylogeography of HBV genotypes,particularly those concerning the origin and dispersion histories of genotypes A,D,E and F and their subgenotypes.The lack of any consensus concerning the HBV substitution rate and the conflicting data obtained using different calibration approaches make the time of origin and divergence of the various genotypes and subgenotypes largely uncertain.It is hypothesised that HBV evolutionary rates are time dependent,and that the changes depend on the main transmission routes of the genotypes and the dynamics of the infected populations. | Gianguglielmo Zehender Erika Ebranati Elena Gabanelli Chiara Sorrentino Alessra Lo Presti Elisabetta Tanzi Massimo Ciccozzi Massimo Galli | 2014 | World Journal of Gastroenterology2014，20，24： | 3 |
| 5 | Epidemiological network analysis in HIV-1 B infected patients diagnosed in Italy between 2000 and 2008显示文摘 | Annapaola Callegaro Valentina Svicher Claudia Alteri Alessandra Lo Presti Daniela Valenti Antonio Goglio Marco Salemi Eleonora Cella Carlo Federico Perno Massimo Ciccozzi Franco Maggiolo | 2011 | Infection, Genetics and Evolution2011，，3： | 2 |
| 6 | Zika virus spreading in South America: evolutionary analysis of emerging neutralizing resistant Phe279Ser strains显示文摘Objective: To investigate the genetic diversity of Zika virus(ZIKV) and the relationships existing among these circulating viruses worldwide. To evaluate the genetic polymorphisms harboured from ZIKV that can have an influence on the virus circulation. Methods: Three different ZIKV dataset were built. The first dataset included 63 E gene sequences, the second one 22 NS3 sequences and the third dataset was composed of 108 NS5 gene sequences. Phylogenetic and selective pressure analysis was performed. The edited nucleic acid alignment from the Envelope dataset was used to generate a conceptual translation to the corresponding peptide sequences through UGene software. Results: The phylogeographic reconstruction was able to discriminate unambiguously that the Brazilian strains are belonged to the Asian lineage. The structural analysis reveals instead the presence of the Ser residue in the Brazilian sequences(however already observed in other previously reported ZIKV infections) that could suggest the presence of a neutralization-resistant population of viruses. Conclusions: Phylogenetic, evolutionary and selective pressure analysis contributed to improve the knowledge on the circulation of ZIKV. | Marta Giovanetti Teresa Milano Luiz Carlos Alcantara Laura Carcangiu Eleonora Cella Alessia Lai Alessandra Lo Presti Stefano Pascarella Gianguglielmo Zehender Silvia Angeletti Massimo Ciccozzi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，5： | 2 |
| 7 | Reconstruction of the evolutionary dynamics of the hepatitis C virus 1b epidemic in Turkey显示文摘 | Massimo Ciccozzi Anna-Rita Ciccaglione Alessandra Lo Presti Tulay Yalcinkaya Zeynep Pinar Taskan Michele Equestre Angela Costantino Roberto Bruni Erica Ebranati Marco Salemi Rebecca Gray Giovanni Rezza Massimo Galli Gianguglielmo Zehender | 2011 | Infection, Genetics and Evolution2011，，： | 2 |
| 8 | Multicast topology inference from measured end- toend loss显示文摘 | Duffield N Horowitz J LO Presti F | 2002 | IEEE Trans Inform2002，48，： | 1 |
| 9 | Pathophysiology of polymorpho-nuclear leukocyte in arterial hypertension 显示文摘 | Hopps E Lo Presti R Caimi G | 2009 | Clin HemorheolMicrocirc2009，41，3： | 1 |
| 10 | Network loss tomography using striped unicast probes显示文摘 | Duffield N G Lo Presti F Paxson V | 2006 | IEEE/ACM Transaction on Networking2006，14，4： | 1 |
| 11 | Recycled tyre rubber modified bitumens for road asphalt mixtures: A literature review显示文摘 | Lo Presti D | 2013 | Construction and Building Materials2013，49，： | 1 |
| 12 | Explicit Loss Inference in Multicast Tomography 显示文摘 | DUFFIELD N G HOROWITZ J LO PRESTI F | 2006 | IEEE Transactions on Information Theory2006，52，8： | 1 |
| 13 | Impact of GPS acquisition strategy on decision probabilitiet; 显示文摘 | BORIO D CAMORIANO L LO PRESTI L | 2008 | IEEE Transactions on Aerospace and Electronic Systems2008，44，3： | 1 |
| 14 | Treatment of chronic patellar dislocation with a modified Elmslie -TriUat procedure显示文摘 | Marcacci M Zaffagnini S Lo Presti M | 2004 | Arch Orthop Trauma Surg2004，124，4： | 1 |
| 15 | Definition of a laborato ry optimization protocol for road bitumen improved with recy- cled tire rubber显示文摘 | Celauro B Celauro C Lo Presti D | 2012 | Construction and Building Materials2012，37，： | 1 |
| 16 | A pediatric case of Schoenlein-Henoch purpura with clinical,serologic and electrocardiographic signs of myocardial damage显示文摘 | Bellantoni A Lo Presti P Giordano A | 2013 | G Ital Cardiol (Rome)2013，14，9： | 1 |
| 17 | Treatment if chronic patellar dislocation with a modified Elmslie-Trillat procedure显示文摘 | Mareacei M Zaffagnini S Lo Presti M | 2004 | Arch Orthop Trauma Surg2004，124，4： | 1 |
| 18 | A pluvial deposition method to reconstitute well-graded sand specimens 显示文摘 | FRETTI C LO PRESTI D C F PEDRONI S | 1995 | Geotech Testing J1995，18，2： | 1 |
| 19 | Preliferative response of lymphocytes from cancer patients to autologous tumor cells显示文摘 | Allarena P Presti LO De Bello M | 1988 | Immunol Immunolther1988，27，： | 1 |
| 20 | Explicit loss in- ference in multicast tomography 显示文摘 | Duffield N G Horowitz J Lo Presti F | 2006 | IEEE Transactions on Information Theory2006，52，8： | 1 |
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