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| 1 | Co-localization hypothesis:A mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis显示文摘尖锐胰腺炎通常被相信是胰被它通常生产的消化酶在伤害的疾病。当是的不活跃的酶原通常仅仅在入口之上激活进十二指肠,但是在尖锐胰腺炎的早阶段期间,那些酶原变得过早地在胰以内并且,大概激活,大多数胰腺的腺泡房间生产的潜在地有害的消化酶被综合并且藏匿那激活发生在胰腺的腺泡房间以内。为消化酶酶原的细胞内部的激活负责的机制没与必然被阐明,但是根据一个广泛地公认的理论(“合作本地化假设”) ,消化酶酶原被 lysosomal 水疗院激活当酶的二种类型在一样的细胞内部的分隔空间以内变得 co 局部性时,放射激光。这评论集中于在胰腺炎的早阶段期间作为对消化酶激活的解释支持合作本地化假设的有效性的证据。调查结果,在这评论总结了,支持 lysosomal 水疗院的合作本地化与消化酶酶原戏放射激光的结论在允许导致腺泡房间损害和胰腺炎的消化酶的细胞内部的激活的一个关键角色。 | Gijs JD van Acker George Perides Michael L Steer | 2006 | World Journal of Gastroenterology2006，12，13： | 10 |
| 2 | Family integrated care:Supporting parents as primary caregivers in the neonatal intensive care unit显示文摘Family integrated care (FICare) is a collaborative model of neonatal care which aims to address the negative impacts of the neonatal intensive care unit (NICU) environment by involving parents as equal partners, minimizing separation, and supporting parent-infant closeness. FICare incorporates psychological, educational, communication, and environmental strategies to support parents to cope with the NICU environment and to prepare them to be able to emotionally, cognitively, and physically care for their infant. FICare has been associated with improved infant feeding, growth, and parent wellbeing and self-efficacy;important mediators for long-term improved infant neurodevelopmental and behavioural outcomes. FICare implementation requires multi-disciplinary commitment, staff motivation, and sufficient time for preparation and readiness for change as professionals relinquish power and control to instead develop collaborative partnerships with parents. Successful FICare implementation and culture change have been applied by neonatal teams internationally, using practical approaches suited to their local environments. Strategies such as parent and staff meetings and relational communication help to break down barriers to change by providing space for the co-creation of knowledge, the negotiation of caregiving roles and the development of trusting relationships. The COVID-19 pandemic highlighted the vulnerability within programs supporting parental presence in neonatal units and the profound impacts of parent-infant separation. New technologies and digital innovations can help to mitigate these challenges, and support renewed efforts to embed FICare philosophy and practice in neonatal care during the COVID-19 recovery and beyond. | Chandra Waddington Nicole Rvan Veenendaal Karel O’Brien Neil Patel for the International Steering Committee for Family Integrated Care | 2021 | Pediatric Investigation2021，5，2： | 9 |
| 3 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 4 | 2005年广州市结核病现况抽样调查显示文摘目的了解广州市结核病的流行现状及危害程度,评价广州市结核病防治措施,为制定广州市2006至2010年结核病防治规划提供科学依据。方法采用整群随机和按人口比例抽样方法,抽样人口比例为1:158。广州市应有流行病学调查点为24个,平均每个调查点的应检人数为1656人。对调查点0~14岁儿童进行结核菌素纯蛋白衍生物试验,询问其卡介苗接种史并检查卡痕;对结核菌素反应≥10 mm,或虽<10 mm 但伴有水疱等强反应的儿童和≥15岁应检人口进行 X 线胸透;对疑有肺结核症状者、X 线胸透有异常阴影及已知肺结核患者均拍摄胸部 X 线片;对 X 线胸透异常及疑有肺结核症状者进行痰涂片和痰培养检查,对培养阳性的标本进行菌种鉴定。结果广州市活动性肺结核患病率为201/10万,涂阳肺结核患病率为33/10万,菌阳肺结核患病率为43/10万;14岁以下儿童中未发现活动性肺结核患者,15~50岁组活动性肺结核患病率为72.5/10万~176.8/10万,80岁以上达高峰,以老年男性最高(2341/10万);已知活动性肺结核、涂阳和菌阳肺结核分别为35.0%(28/80)、61.5%(8/13)和47.1%(8/17);初治活动性肺结核、涂阳和菌阳肺结核分别为81.3%(65/80)、69.2%(9/13)和58.8%(10/17);55岁以上组的复治活动性肺结核患者占80.0%。结论广州市的结核病患病率仍较高,老年菌阳肺结核仍较多。 | Guangzhou Technique Steering Group of the Epidemiological Sampling Survey for Tuberculosis | 2007 | 中华结核和呼吸杂志2007，30，6： | 6 |
| 5 | Lyme病显示文摘据报道应用细胞抑制剂可增加癌症病人血栓栓塞的危险.关于化疗后触发血液凝固和纤维蛋白溶解的生物学改变的机制,目前尚不清楚.作者选择40例无法手术的Ⅲ、Ⅳ期肺癌化疗病人进行研究,以探讨化疗对这些病人纤维蛋白溶解和血液凝固系统的影响. | Steere AC 余传霖 | 1990 | 国外医学(微生物学分册)1990，13，2： | 4 |
| 6 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 7 | 美国食醋市场最新动态及发展趋势显示文摘 | 涂志英 邵伟 Harald Steer | 2006 | 中国酿造2006，25，12： | 3 |
| 8 | 1986~1990年我国丝虫病防治研究进展显示文摘根据丝虫病流行区各省、自治区、直辖市的统计资料,1986—1990年全国共血检普查22 350 772人次,查出微丝蚴阳性者268 034人,海群生治疗78 550 945人次。5年内又有162个县、市达到基本消灭丝虫病的指标,使累计达到基本消灭丝虫病指标的县、市增至823个,占全国(除台湾省外)864个流行县、市的95.3%。已达基本消灭丝虫病指标的地区,正将丝虫病防治工作转入监测管理阶段。据各地开展定点纵向监测的初步结果,显示在不追加防治措施的情况下,人群微丝蚴率几乎均持续降低,IFAT阳性率和抗体滴度亦呈下降趋势,仅个别班氏丝虫病流行区的纵向监测点,由于尚存在较高密度的残存微丝蚴血症者,仍可发现阳性蚊媒。5年中,有关丝虫病防治后期流行规律、血清学监测方法及丝虫病症状体征治疗方法等项研究亦取得了新的进展。 | National Technical Steering Group for Filariasis Control and Research, MOPH | 1991 | 中国寄生虫学与寄生虫病杂志1991，9，2： | 3 |
| 9 | A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events 显示文摘 | CAPRIE Steering Committee | 1996 | Lancet1996，348，9038： | 2 |
| 10 | Acute pancreatitis显示文摘 | Jean-Louis Frossard Michael L Steer Catherine M Pastor | 2008 | The Lancet2008，，9607： | 2 |
| 11 | P250 Central nervous system (CNS) complications of ear nose throat (ENT) infections – case series显示文摘 | N. Vora P.D. Eunson K.K. Tallur A. Baxter R.A. Minns A.J.W. Steers L. Myles A.E. McLellan | 2009 | European Journal of Paediatric Neurology2009，，： | 2 |
| 12 | 用于高速ADC的串行接口显示文摘在诸如核磁共振成像(MRI)、超声波、CT扫描仪、数字X射线等医疗应用中,经常需要使用多通道的模数转换器(ADC)来对大量数据采样。用串行接口来获取采样数据可减少ADC与FPGA的引脚数并节省电路板空间。目前有串行LVDS和JESD204接口标准可供选择。本文将就这两种类型进行探讨。 | Alison Steer | 2011 | 电子产品世界2011，18，10： | 2 |
| 13 | The role and regulation of COX-2 during viral infection 显示文摘 | Steer S A Corbett J A | 2003 | Viral Immunol2003，16，4： | 1 |
| 14 | Effects of stimulus and cell type on the expression of the -308 tumour necrosis factor promoter polymorphism 显示文摘 | Kroeger KM Steer JH Joyce DA | 2000 | Cytokine2000，12，2： | 1 |
| 15 | A randomized, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events(CAPRIE) 显示文摘 | CAPRIE Steering Committee | 1996 | Lancet1996，348，： | 1 |
| 16 | Organizational work and personal factors in employee turnover and absenteeism显示文摘 | Porter L and Steer R | 1973 | Psychology Bulletin1973，80，2： | 1 |
| 17 | Final report on the aspirin component of the ongoing Physicians' Health Study显示文摘 | Steering Committee of the Physicians'Health Study Research Group | 1989 | N Engl J Med1989，321，： | 1 |
| 18 | Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis 显示文摘 | Watanabe O Baccino FM Steer ML | 1984 | Am J Physiol1984，246，41： | 1 |
| 19 | A test of four plant species to reduce total nitrogen and total phosphorus from soil leachate in subsurface wetland microcosms显示文摘 | Lauchlan H Fraser Spring M Carty David Steer | 2004 | Bioresour Technol2004，94，： | 1 |
| 20 | Lack of RH C/E expression in the rhesus D-phenotype is the result of a gene deletion显示文摘 | Blunt T Steers F Daniels G | 1994 | Ann Hum Genet1994，，： | 1 |
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