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| 1 | Factors predicting poor prognosis in ischemic colitis显示文摘瞄准:决定临床、分析、内视镜的因素与有关是化学家大肠炎(IC ) 严厉。方法:85 个病人的一个总数从 1996 年 1 月在回顾的研究被注册到 2004 年 5 月。有 53 女性和 32 男性(年龄 74.6+/-9.4 年,范围 45-89 年) 。病人作为 IC 被诊断。下列变量包括年龄,性别,从到承认的症状的外观的时间的经期,病历,药,凳子频率,临床的症状和症状被分析,验血(血克和基本生物化学的侧面) ,和内视镜的调查结果。病人们在温和 IC 组和严重 IC 组(外科或死亡) 被划分。质的变量用 chi 平方测试被分析,参量的数据用学生的 t (P<0.05 ) 被分析。结果:温和 IC 组 69 个病人被在于(42 女性和 27 男性,平均年龄 74.7+/-12.4 年) 。严重 IC 组由 16 个病人组成(11 女性和 5 男性,平均 73.8+/-12.4 年的年龄) 。因为麦克匪特斯氏疗法(没有外科) 的失败,一个病人死了, 15 个病人经历了外科(6 在内视镜的诊断以后并且 9 在 peroperatory 以后诊断) 。85 个病人(9.6%) 中的八个死了,其它被跟随在上面作为为 9.6+/-3.5 瞬间的门诊病人。人口统计的数据,病历,药和凳子频率在两个组(P>0.05 ) 是类似的。说正经的有病的病人比稍微有病的病人有更少的便血(37.5% 对 86.9% , P = 0.000 ) 。更多的心悸亢进(45.4% 对 10.1% , P = 0.011 ) 并且假腹膜炎的更高的流行签名(75% 对 5.7% , P = 0.000 ) 当腹的疼痛的存在和紧张在二个组之间是类似的时,在严重 IC 组被观察。当承认时,有严重 IC 的二个病人有吃惊。关于分析数据,更严重有病的病人被发现比略微有病的病人有贫血症和血钠过少(37.5% 对 10.1% , P = 0.014 和 46.6% 对 14.9% , P = 0.012,分别地) 。狭窄是那比在稍微有病的病人更经常出现在严重有病的病人的唯一的内视镜的发现(66.6% 对 17.3% , P = 0.017 ) 。结论:能预言 IC 的差的预后是便血,心悸亢进和假腹膜炎,贫血症和血钠过少和狭窄的缺席的因素。 | Ramón A■ón Marta Maia Boscá Vicente Sanchiz Joan Tosca Pedro Almela Cirilo Amorós Adolfo Benages | 2006 | World Journal of Gastroenterology2006，12，30： | 21 |
| 2 | COX-2 in liver,from regeneration to hepatocarcinogenesis:What we have learned from animal models?显示文摘The use of animals lacking genes or expressing genes under the control of cell-specific promoters has signifi cantly increased our knowledge of the genetic and molecular basis of physiopathology,allowing testing of functional hypotheses and validation of biochemical and pharmacologic approaches in order to understand cell function.However,with unexpected frequency,gene knockout animals and,more commonly,animal models of transgenesis give experimental support to even opposite conclusions on gene function.Here we summarize what we learned on the role of cyclooxygenase 2(COX-2) in liver and revise the results obtained in 3 independent models of mice expressing a COX-2 transgene specifi cally in the hepatocyte.Upon challenge with pro-inflammatory stimuli,the animals behave very differently,some transgenic models having a protective effect but others enhancing the injury.In addition,one transgene exerts differential effects on normal liver physiology depending on the transgenic animal model used. | Paloma Martín-Sanz Rafael Mayoral Marta Casado Lisardo Boscá | 2010 | World Journal of Gastroenterology2010，16，12： | 12 |
| 3 | Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives显示文摘The biosynthesis of prostaglandins and thromboxanes has been a focus of interest in the management of many liver diseases.Cyclooxygenases are the enzymes involved in the first step of the biosynthesis of these lipid mediators and selective inhibitors for these isoenzymes as well as pharmacological analogues of prostaglandins have been developed and are currently applied therapeutically.Here we discuss the implications of these enzymes in the onset of metabolic and lipid disorders in the liver and their potential role in the progression of the diseases towards fibrosis and hepatocellular carcinogenesis. | Paloma Martín-Sanz Marta Casado Lisardo Boscá | 2017 | World Journal of Gastroenterology2017，23，20： | 7 |
| 4 | Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer:An update显示文摘The biosynthesis of prostanoids is involved in both physiological and pathological processes. The expression of prostaglandin-endoperoxide synthase 2(PTGS2; also known as COX-2) has been traditionally associated to the onset of several pathologies, from inflammation to cardiovascular, gastrointestinal and oncologic events. For this reason, the search of selective PTGS2 inhibitors has been a focus for therapeutic interventions. In addition to the classic non-steroidal anti-inflammatory drugs, selective and specific PTGS2 inhibitors, termed coxibs, have been generated and widely used. PTGS2 activity is less restrictive in terms of substrate specificity than the homeostatic counterpart PTGS1, and it accounts for the elevated prostanoid synthesis that accompanies several pathologies. The main regulation of PTGS2 occurs at the transcription level. In addition to this, the stability of the mRNA is finely regulated through the interaction with several cytoplasmic elements, ranging from specificmicroR NAs to proteins that control mR NA degradation. Moreover, the protein has been recognized to be the substrate for several post-translational modifications that affect both the enzyme activity and the targeting for degradation via proteasomal and non-proteasomal mechanisms. Among these modifications, phosphorylation, glycosylation and covalent modifications by reactive lipidic intermediates and by free radicals associated to the proinflammatory condition appear to be the main changes. Identification of these post-translational modifications is relevant to better understand the role of PTGS2 in several pathologies and to establish a correct analysis of the potential function of this protein in diseases progress. Finally, these modifications can be used as biomarkers to establish correlations with other parameters, including the immunomodulation dependent on molecular pathological epidemiology determinants, which may provide a better frame for potential therapeutic interventions. | Rafael I Jaén Patricia Prieto Marta Casado Paloma Martín-Sanz Lisardo Boscá | 2018 | World Journal of Gastroenterology2018，24，48： | 5 |
| 5 | Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort显示文摘BACKGROUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in humans.AIM To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic profile.METHODS Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AVIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a QExactive HF orbitrap MS.RESULTS Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGE2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PNGase F incubation, showing higher PGE2 levels. Moreover,HRMAS analysis indicated that tumor tissue has altered metabolic features vs non-tumor counterparts, presenting increased levels of certain metabolites such as taurine and phosphocholine and lower levels of lactate. In proteomic experiments, we detected an enlarged number of proteins in tumors that are mainly implicated in basic biological functions like mitochondrial activity,DNA/RNA processing, vesicular trafficking, metabolism, cytoskeleton and splicing.CONCLUSION In our colorectal cancer cohort, tumor tissue presents a differential COX-2 expression pattern with lower enzymatic activity that can be related to an altered metabolic and proteomic profile. | Patricia Prieto Rafael I Jaén Daniel Calle María Gómez-Serrano Estefanía Nú?ez María Fernández-Velasco Paloma Martín-Sanz Sergio Alonso Jesús Vázquez Sebastián Cerdán Miguel ángel Peinado Lisardo Boscá | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 6 | Late complications of pancreas transplant显示文摘To summarize the long-term complications after pancreas transplantation that affect graft function,a literature search was carried out on the long-term complications of pancreatic transplantation,namely,complications from postoperative 3rd mo onwards,in terms of loss of graft function,late infection and vascular complications as pseudoaneurysms.The most relevant reviews and studies were selected to obtain the current evidence on these topics.The definition of graft failure varies among different studies,so it is difficult to evaluate,a standardized definition is of utmost importance to know the magnitude of the problem in all worldwide series.Chronic rejection is the main cause of long-term graft failure,occurring in 10%of patients.From the 3rd mo of transplantation onwards,the main risk factor for late infections is immunosuppression,and patients have opportunistic infections like:Cytomegalovirus,hepatitis B and C viruses,Epstein-Barr virus and varicella-zoster virus;opportunistic bacteria,reactivation of latent infections as tuberculosis or fungal infections.Complete preoperative studies and serological tests should be made in all recipients to avoid these infections,adding perioperative prophylactic treatments when indicated.Pseudoaneurysm are uncommon,but one of the main causes of late bleeding,which can be fatal.The treatment should be performed with radiological endovascular approaches or open surgery in case of failure.Despite all therapeutic options for the complications mentioned above,transplantectomy is a necessary option in approximately 50%of relaparotomies,especially in lifethreatening complications.Late complications in pancreatic transplantation threatens long-term graft function.An exhaustive follow-up as well as a correct immunosuppression protocol are necessary for prevention. | Javier Maupoey Ibáñez Andrea BoscàRobledo Rafael López-Andujar | 2020 | World Journal of Transplantation2020，10，12： | 2 |
| 7 | Convective and diffusive losses of vitamin C during haemodiafiltration sessions: a contributive factor to oxidative stress in haemodialysis patients显示文摘 | Morena M Cristol JP Bosc JY | 2002 | Nephrol Dial Transplant2002，17，3： | 1 |
| 8 | Algal Biomass and Sea Surface Temperature in the Mediterranean Basin-intercomparison of Data from Various Satellite Sensors,and Implications for Primary Production Estimates显示文摘 | Bricaud A Bosc E Antoine D | 2002 | Rem Sens Env2002，81，23： | 1 |
| 9 | Mesoporous TiO2-based photocatalystsfor UV and visible light gas-phase toluene degradation显示文摘 | Bosc F Edwards D Keller N | 2006 | Thin Solid Films2006，495，： | 1 |
| 10 | Identification and characterization of CKIP-1,a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2显示文摘 | Bosc DG Graham KC Saulnier RB | | 0，，19： | 1 |
| 11 | Urea as a marker of adequacy in hemodialysis : Lesson from in vivo urea dynamics monitoring显示文摘 | Canaud B Bosc JY Cabrol L | 2000 | Kidney Int2000，58，： | 1 |
| 12 | Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners显示文摘 | Litchfield DW Bosc DG Canton DA | 2001 | Mol Cell Biochem2001，227，12： | 1 |
| 13 | Development of controlled porosity polymer-ceramic composite scaffolds via fused deposition modeling显示文摘 | Kalita SJ Bosc S Hosick HL | 2003 | Materials Science and Engineering C2003，23，： | 1 |
| 14 | Urea rebound and delivered Kt/V determination with a continuous urea senser显示文摘 | Canaud B Bosc JY | 1997 | Nephrol Dial Transplant1997，12，3： | 1 |
| 15 | A simple and accurate method to determine equilibrated post-dialysis urea concentration显示文摘 | Bosc JY Garred LJ | 1997 | Kidney Int1997，51，6： | 1 |
| 16 | Variability of stem and branch maintenance respiration in a Pinus pinastertree显示文摘 | Bosc A de Grandcourt A Loustau D | 2003 | Tree Physiology2003，23，4： | 1 |
| 17 | Erythropoietin and oxidative stress in hacmodialysis: benefical effects of vitamin E supplemention 显示文摘 | Cristol JP Bosc JY Badiou S | 1997 | Nephrol Dial Transplant1997，12，11： | 1 |
| 18 | Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease显示文摘 | Bosc C Clement M Deroux A | 2014 | Rev Mal Respir2014，31，5： | 1 |
| 19 | SQLf: A Relational Database Language for Fuzzy Querying显示文摘 | Bosc E Pivert O | 1995 | IEEE Transactions on Fuzzy Systems1995，3，1： | 1 |
| 20 | Paclitaxel-bevacizumab is a possible alternative as salvage chemotherapy in advanced nonsmall cell bronchial carcinoma显示文摘 | Zarza V Couraud S Bosc C | 2014 | Rev Mal Respir2014，31，7： | 1 |
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