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| 1 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 2 | Predictive factors for rhabdomyolysis after bariatric surgery 显示文摘 | LAGANDRE S ARNALSTEEN L VALLET B | 2006 | Obes Surg2006，16，10： | 1 |
| 3 | Yeno-arterial CO2 difference during regional ischemic or hypoxie hypoxia 显示文摘 | Vallet B Teboul JL Cain S | 2000 | J Appl Physiol2000，89，4： | 1 |
| 4 | Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease显示文摘 | Vallet S Mukherjee S Vaghela N | 2010 | Proc Natl Acad Sci U S A2010，107，： | 1 |
| 5 | Cyclooxygenase-2 ( COX-2 ) is frequnently expressed in multiple myeloma and is an independent predictor of poor outcome 显示文摘 | Ladetto M Vallet S Trojan A | 2005 | Blood2005，105，12： | 1 |
| 6 | A novel role for CCL3(MIP-1α)in myeloma-induced bone disease via osteocalcin down-regulation and inhibition of osteoblast function显示文摘 | Vallet S Pozzi S Patel K | 2011 | Leukemia2011，25，7： | 1 |
| 7 | A novel role for CCL3(MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function显示文摘 | Vallet S Pozzi S Patel K | 2011 | Leukemia2011，25，7： | 1 |
| 8 | Activin A promotes multiple myeloma induced osteolysis and is a promising target for myeloma bone disease显示文摘 | Vallet S Mukherjee S Vaghela N | 2010 | Proc Nat Acad Sci U S A2010，107，： | 1 |
| 9 | Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma显示文摘 | Breitkreutz I Raab MS Vallet S | 2008 | Leukemia2008，22，10： | 1 |
| 10 | NS3 protease polymorphism and natural resistance to protease inhibitors in French patients infected with HCV genotypes 1-5显示文摘 | Vallet S Viron F Henquell C | 2011 | AntivirTher2011，16，7： | 1 |
| 11 | Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: A relevant ex vivo model of liver infection显示文摘 | Sylvie Lagaye Hong Shen Bertrand Saunier Michelina Nascimbeni Jesintha Gaston Pierre Bourdoncle Laurent Hannoun Pierre‐Philippe Massault Ana?s Vallet‐Pichard Vincent Mallet Stanislas Pol | 2012 | Hepatology2012，，3： | 1 |
| 12 | Characterization of the human CD5 endogenous retrovirus-E in B lymphocytes显示文摘 | Renaudineau Y Vallet S Le Dantec C | 2005 | Genes Immun2005，6，8： | 1 |
| 13 | Bone anabolic agents for the treatment ofmultiple myeloma显示文摘 | Vallet S Raje N | 2011 | Cancer Microenviron2011，4，33： | 1 |
| 14 | Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma显示文摘 | Breitkreutz I Raab MS Vallet S | 2008 | Leukemia2008，22，10： | 1 |
| 15 | Venoarterial CO2 difference during regional ischemic or hypoxic hypoxia显示文摘 | Vallet B Teboul JL Cain S | 2000 | J Appl Physiol2000，89，4： | 1 |
| 16 | Flavor release and theology behavior of strawberry fat-free stirred yogurt during storage显示文摘 | Lubbers S Decourcelle N Vallet N | 2004 | J Agric Food Chem2004，52，10： | 1 |
| 17 | Sotatercept,a soluble activin receptor type 2A IgG-Fc fusion protein for the treatment of anemia and bone loss显示文摘 | Raje N Vallet S | 2010 | Curr Opin Mol Ther2010，12，： | 1 |
| 18 | Comparison of two training programmes in chronic airway limitation patients:standardized versus individualized protocols显示文摘 | Vallet G Ahmaidi S Serres I | | 0，，： | 1 |
| 19 | Concurrent administration of high-dose chemotherapy and rituximab is a feasible and effective chemo/immunotherapy for patients with high-risk non-Hodgkin's lymphoma显示文摘 | Ladetto M Zallio F Vallet S | 2001 | Leukemia2001，15，： | 1 |
| 20 | Novel bone targeted strategies in oncology 显示文摘 | Vallet S Smith MR Raje N | 2010 | Clin Cancer Res2010，16，16： | 1 |
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