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| 1 | Pathogenesis of occult chronic hepatitis B virus infection显示文摘Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological patterns.Occult HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene expression.OBI is an entity with world-wide diffusion.The failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this'occult'HBV infection;although the mechanisms responsible for suppression of HBV are not well understood.The majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV infection.Much evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma. | Rocio Aller de la Fuente María L Gutiérrez Javier Garcia-Samaniego Conrado Fernández-Rodriguez Jose Luis Lledó Gregorio Castellano | 2011 | World Journal of Gastroenterology2011，17，12： | 12 |
| 2 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 3 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 4 | Partial hepatectomy, partial portal vein stenosis and mesenteric lymphadenectomy increase splanchnic mast cell infiltration in the rat显示文摘 | Luis M. Moquillaza María-Angeles Aller Maria-Paz Nava Luis Santamaría Patri Vergara Jaime Arias | 2009 | Acta Histochemica2009，，4： | 1 |
| 5 | Ultrasound guided combined cryoablation and microencapsulated 5-Fluorouracil inhibits growth of human prostate tumors in xenogenic mouse model assessed by luminescence imaging显示文摘 | Le Pivert P Haddad RS Aller A | 2004 | Technol Cancer Res Treat2004，3，2： | 1 |
| 6 | Transport and transformation of dissolved and particulate materials on conti- nental margins influenced by major rivers: benthic boundary layer and seabed processes 显示文摘 | Mekee B A Aller R C Allison M A | 2004 | Continental Shelf Research2004，24，78： | 1 |
| 7 | Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines显示文摘 | Ramos A M Aller P | 2008 | Biochemical Pharmacology2008，75，10： | 1 |
| 8 | Biodesulphurisation of coal by microorganisms isolated from the coal itseli显示文摘 | Aller A Martinez O Linaje J A | 2001 | Fuel Processing Technology2001，69，： | 1 |
| 9 | Pearson-readhead survey sources-properties of the centimeter-wavelength flux and polarization of a complete radio sample显示文摘 | Aller M F Aller H D Hughes P A | 1992 | ApJ1992，399，： | 1 |
| 10 | Relation of osteoealcin with insulin resistance and histopathological changes of non alcoholic fatty liver disease显示文摘 | ALLER R CASTRILLON J L P DE LUIS D A | 2011 | Ann Hepatol2011，10，1： | 1 |
| 11 | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding显示文摘 | Aller SG Yu J Ward A | | 0，，5922： | 1 |
| 12 | Role of -55CT polymorphism of UCP3 gene on non alcoholic fatty liver disease and insulin resistance in patients with obesity显示文摘 | Aller R De Luis D A Izaola O | | 0，，04： | 1 |
| 13 | Dietary intake in patients with asthma:a case control study显示文摘 | de Luis DA Armentia A Aller R | 2005 | Nutritian2005，21，3： | 1 |
| 14 | Nonstationary Motor Fault Detection Using Recent Quadratic Time-Frequency Representa- tions显示文摘 | Rajagopalan S Restrepo J A Aller J M | 2008 | IEEE Transactions on Industry Applications2008，44，3： | 1 |
| 15 | Biodesulphurisation of coal by microorganisms isolated from the coal itself显示文摘 | Aller A Martnez O | 2001 | Fuel Processing Technology2001，66，： | 1 |
| 16 | Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding 显示文摘 | Aller S G Yu J Ward A | 2009 | Science2009，323，17： | 1 |
| 17 | Importance of suspended particulates in riverine delivery of bioavailable nitrogen to coastal zones 显示文摘 | Mayer L M Keil R G Macko S A Joye S B Ruttenberg K C Aller R C | 1998 | Global Biogeochem Cycles1998，12，4： | 1 |
| 18 | Trace metals and dissolved organic carbon in an estuary with restricted river flow and a brown tide bloom显示文摘 | Breuer E Saudo-Wilhelmy S A and Aller R C | 1999 | Estuaries1999，22，： | 1 |
| 19 | Structure of P-gly- coprotein reveals a molecular basis for poly-spe- cific drug binding 显示文摘 | Aller SG Yu J Ward A | 2009 | Science2009，323，5922： | 1 |
| 20 | Bayesian reliability analysis of series systemsof binomialsubsystems and components显示文摘 | M artz H F W aller F A F ickas E T | 1998 | Technometrics1998，30，2： | 1 |
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