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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | A multiplex, real-time PCR assay for rapid identification of Mycobacterium tuberculosis complex members to the species level显示文摘 | Pinsky B A Banaei N | 2008 | J Clin Microbiol2008，46，7： | 1 |
| 3 | Assessing contamination and compliance in the prostate component of the prostate,lung,colorectal,and ovarian (PLCO) Cancer Screening Trial显示文摘 | PINSKY PF BLACKA A KRAMER BS | | 0，，4： | 1 |
| 4 | A Retro- spective Analysis of Immunosuppression Compliance, Dose Reduction and Discontinuation in Kidney Transplant Recipi- ents显示文摘 | Takemoto S K Pinsky B W Schnitzler M A | 2007 | Am J Transplant2007，7，12： | 1 |
| 5 | Estimating cardiac filling pressure in mechanically ventilated patients with hyperinflation 显示文摘 | Teboul JL Pinsky MR Mereat A | 2000 | Crit Care Med2000，28，2： | 1 |
| 6 | Estimating cardiac filling pressure in mechanically ventilated patients with hyperinflation显示文摘 | Teboul JL Pinsky MR Mercat A | 2000 | Crit Care Med2000，28，1： | 1 |
| 7 | The role of competition effect in the raindrop formation显示文摘 | Segal Y M Pinsky A K | 2007 | Atmos Res2007，83，： | 1 |
| 8 | Gleaning knowledge from data in the intensive care unit 显示文摘 | Pinsky MR Dubrawski A | 2014 | American Journal of Respiratory and Critical Care Medicine2014，190，6： | 1 |
| 9 | Suppression of cytokine-mediated beta2-integrin activation on circulating neutrophils in critically ill patients显示文摘 | Rosenbloom A J Pinsky M R Napolitano C | 1999 | J Leukoc Biol1999，66，： | 1 |
| 10 | Transvisceral lactate fluxes during early endotoxemia 显示文摘 | Bellomo R Kellum J A Pinsky M R | 1996 | Chest1996，110，1： | 1 |
| 11 | Introduction to Fourier Analysis and Wavelets显示文摘 | Pinsky M A | 2002 | Boo/Cole2002，，： | 1 |
| 12 | Multiplex Real-time PCR assay for rapid identification of Mycobacterium tuberculosis complex members to the species level显示文摘 | Pinsky B A Banari N | 2008 | Jounrnal of Clinical Microbiology2008，46，7： | 1 |
| 13 | First documentation of isoniazid reversion in Mycobacterium tuberculosis显示文摘 | Richardson E T Lin S Y Pinsky B A Desmond E Banaei N | 2009 | Int J Tuberc Lung Dis2009，13，： | 1 |
| 14 | The role of the complement cascade in ischemia/reperfusion injury: implications for neuroprotection 显示文摘 | D'Ambrosio A L Pinsky D J Connolly E S | 2001 | Mol Med2001，7，6： | 1 |
| 15 | Biochemistry of lipoxygenase in relation to food quality显示文摘 | Eskin N A M Grossman S Pinsky A | 1977 | Crit Rev Food Sci Nutr1977，9，1： | 1 |
| 16 | Simulation of effects of atmospheric aerosols on deep turbulent convective clouds using a spectral microphysics mixed-phase cumulus cloud model:part- I : model description and possible applications显示文摘 | KHAIN A POKROVSKY A PINSKY M | 2004 | J Atmos Sci2004，61，24： | 1 |
| 17 | The role of dissolved hydrogen and other trace impurities on propensity of tin deposits to grow whiskers 显示文摘 | PINSKY D A | 2008 | Microelectronies Reliability2008，48，5： | 1 |
| 18 | Growth hormone-releasing hormone antagonist MZ-4-71 inhibits in vivo proliferation of Caki-I renal adenoearcinoma 显示文摘 | Jungwirth A Schally A V Pinski J Groot K Armatis P Halmos G | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 19 | Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of complete left hundle branch block 显示文摘 | Sgarbossa EB Pinski SL Barbagelata A | 1996 | N Eng J Med1996，334，： | 1 |
| 20 | Electrocardiographic Diagnosis of Evolving Acute Myocardial Infarction in the Presence of Left Bundle Branch显示文摘 | Sgarbossa E B Pinski S L Barbagelata A | 1996 | N Engl Med1996，334，： | 1 |
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