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1[^11C]methionine PET, histopathology, and survival in primary brain tumors and recurrence显示文摘Ceyssens S Van Laere K de Groot T Goffin J Bormans G Mortelmans L 2006中国神经肿瘤杂志2006,4,3:13
2Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted.Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh 2015World Journal of Clinical Oncology2015,6,5:4
3Association of depression and diabetes complications: a meta analysis 显示文摘De Groot M Anderson R Freedland K 2001Psychosom Med2001,63,:1
4The value of the world’s ecosystemservices and natural capita1显示文摘Costanza R Arge R Groot R Farberk S Grasso M HannonB Limburg K Naeem S O’Neil R Paruelo J Raskin R Suttonkk P &Belt M 1997Nature1997,387,:1
5Bioceramics consisting of calcium phosphate salts显示文摘De Groot K 1980Biomaterials1980,1,1:1
6Localisation of mRNA for JE/MCP-1 and its receptor CCR2 in atherosclerotic lesions of the ApoE knockout mouse显示文摘Rayner K van Eersel S Groot P H 2000J Vasc Res2000,37,2:1
7Genetic polymor- phisms related to the renin-angiotensin-aldosterone system and response to antihypertensive drugs显示文摘Taverne K de Groot M de Boer A 2010Expert Opin Drug Metab Toxicol2010,6,4:1
8A plastic composite of alginate with calcium phosphate granulate as implant material:an in vive study显示文摘Klein CPAT van der Lubbe HBM de Groot K 1987Biomaterials1987,8,:1
9Proteomlc analysis of Arabidopsis seed germination and priming 显示文摘Gallardo K Job C Groot S P C 2001Plant Physiol2001,126,:1
10Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial 显示文摘de Groot K Harper L Jayne DR 2009Ann Intern Med2009,150,10:1
11Nucleation of biomimetic Ca-P coatings on Ti6A14V from a SBF×5 solution: influence of magnesium 显示文摘BARRERE F VAN BLITTERSWIJK C A DE GROOT K 2002Biomaterials2002,23,10:1
12Proteomic analysis of Arabidopsis seed germination and priming显示文摘Gallardo K Job C Groot SP 2001Plant Physiology2001,126,:1
13The value of pulse cyclophosphamide in ANCA-associated vasculitis:meta-analysis and critical review显示文摘de Groot K Adu D Savage CO 2001Nephrol Dial Transplant2001,16,10:1
14Studies of solubility of different calcium phosphate ceramic particles in vitro显示文摘Klein C P A T Wolke J G C Groot K 1990Biomaterials1990,11,4:1
15Structure and function of water channels显示文摘Fujiyoshi Y Mitsuoka K de Groot B L 2002Curr Opin Struct Biol2002,12,4:1
16Erythropoietin regulates endothelial progenitor cells显示文摘Bahlmann FH de Groot K Spandau JM 2004Blood2004,103,3:1
17Proteomie analysis of Ar- abidopsis seed germination and priming 显示文摘Gallardo K Job C Groots SPC 2001Plant Physiol2001,126,:1
18Proteomic analysis of Arabidopsis seed germination and priming显示文摘Gallardo K Job C Groot S P C 2001Plant Physiol2001,126,:1
19Prolonged enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement:A cost-utility analysis显示文摘Haentjens P De Groote K Annemans L 2004Arch Orthop Trauma Surg2004,124,8:1
20High-power and superpower Cerenkov masers显示文摘De Groot J S Stone R A Mizuno K 1988IEEE Trans Plasma Sci1988,16,2:1
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