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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 3 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 4 | Structure properties of hydroxyapatite obtained by mechanosynthesis 显示文摘 | Silva C C Pinheiro A G Miranda M A R | 2003 | Solid State Sciences2003，5，： | 1 |
| 5 | Immunotherapy for de novo renal transplantation :what's in the pipeline? 显示文摘 | TEDESCO SILVA H JR PINHEIRO MACHADO P ROSSO FELIPE C | 2006 | Drugs2006，66，13： | 1 |
| 6 | Mold fluxes for continuous casting of steel 显示文摘 | Pinheiro C A Samarasekera I V Brimacombe J K | 1995 | Iron and Steel Maker1995，22，4： | 1 |
| 7 | Alterations in car- bon and nitrogen metabolism induced by water deficit in the stems and leaves of Lupinus albus L显示文摘 | PINHEIRO C CHAVES M M RICARDO C P | 2001 | Journal of Experimental Botany2001，52，： | 1 |
| 8 | Photosynthesis underdrought and salt stress:Regulation mechanisms from whole plant to cell 显示文摘 | CHAVES M M FLEXAS J PINHEIRO C | 2009 | Annals of Botany2009，103，： | 1 |
| 9 | Microorganisms from canals of root-filled teeth with periapical lesions显示文摘 | PINHEIRO E T GOMES B P FERRAZ C C | 2003 | Int Endod J2003，36，1： | 1 |
| 10 | Line Current Harmonics Reduction in Hybrid Multilevel Converters Using Phase-Shifting Transformers 显示文摘 | Rech C Pinheiro J R | 2004 | IEEE Power Electronics Specialists Conference2004，35，1： | 1 |
| 11 | Response of antioxidant enzymes in freshwater fish populations (Leuciscus alburnides complex)to inorginanic pollu- tants exposure显示文摘 | Lopes P A Pinheiro T Santos M C | 2001 | Sci Total Environ2001，280，13： | 1 |
| 12 | Determination of Formaldehyde by Acetaldehyde in Urine by HPLC显示文摘 | Deandrade J B Deandrade M V Pinheiro H L C | 1999 | American Laboratory1999，31，10： | 1 |
| 13 | Mold flux for continuous casting of steel显示文摘 | Pinheiro C A Samarasekera I V Brimacombe J K | 1996 | Iron and Steelmaker1996，，23： | 1 |
| 14 | EGFR amplification and lack of activating mutations in metaplastic breast carcinomas显示文摘 | Reis-Filho J Pinheiro C Lambros M | 2006 | Pathol2006，209，4： | 1 |
| 15 | Duodenal-jejunal bypass for the treatment of type 2 diabetes in patients with body mass index of 22 ~ 34 kg/m2:a report of 2 cases显示文摘 | COHEN R V SCH1AVON C A PINHEIRO J S | 2007 | Surg Obes Relat Dis2007，3，2： | 1 |
| 16 | Structural properties of hydroxyapalile obtained by mechanosynlhesis显示文摘 | Silver C C Pinheiro A G Miranda M A R | 2003 | Solid Stale Sciences2003，5，4： | 1 |
| 17 | Prevalence and mechanisms of erythromycin resistance in Streptococcus agalactiae from healthy pregnant women显示文摘 | Pinheiro S Radhouani H Coelho C | 2009 | Microb Drug Resist2009，15，2： | 1 |
| 18 | Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs显示文摘 | Euler Moraes Penha Cássio Santana Meira Elisalva Teixeira Guimar?es Marcus Vinícius Pinheiro Mendon?a Faye Alice Gravely Cláudia Maria Bahia Pinheiro Taiana Maria Bahia Pinheiro Stella Maria Barrouin-Melo Ricardo Ribeiro-dos-Santos Milena Botelho Pereira | 2014 | Stem Cells International2014，，： | 1 |
| 19 | Effects of early feed restriction and enzyme supplementation on digestiveenzyme activities in broilers显示文摘 | Pinheiro D F Cruz V C Sartori J R | 2004 | Poultry Science2004，83，： | 1 |
| 20 | Hybrid multilevel converters: unified analysis and design considerations显示文摘 | Rech C Pinheiro J R | 2007 | IEEE Transactions on Industrial Electronics2007，54，2： | 1 |
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