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| 1 | From portal to splanchnic venous thrombosis:What surgeons should bear in mind显示文摘The present study aims to review the evolution of surgical management of portal(PVT) and splanch-nic venous thrombosis(SVT) in the context of liver transplantation over the last 5 decades. PVT is more commonly managed by endovenous thrombectomy, while SVT requires more complex technical expedients. Several surgical techniques have been proposed, such as extensive eversion thrombectomy, anastomosis to collateral veins, reno-portal anastomosis, cavo-portal hemi-transposition, portal arterialization and combined liver-intestinal transplantation. In order to achieve satisfactory outcomes, careful planning of the surgical strategy is mandatory. The excellent results that are ob-tained nowadays confirm that, even extended, splanch-nic thrombosis is no longer an absolute contraindication for liver transplantation. Patients with advanced portal thrombosis may preferentially be referred to specialized centres, in which complex vascular approaches and even multivisceral transplantation are performed. | Quirino Lai Gabriele Spoletini Rafael S Pinheiro Fabio Melandro Nicola Guglielmo Jan Lerut | 2014 | World Journal of Hepatology2014，6，8： | 6 |
| 2 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 3 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 4 | Integrating geochemical(surface waters, stream sediments)and biological(diatoms) approaches to assess AMD environmental impact in a pyritic mining area: Aljustrel(Alentejo, Portugal)显示文摘Aljustrel mines were classified as having high environmental hazard due to their large tailings volume and high metal concentrations in waters and sediments.To assess acid mine drainage impacted systems whose environmental conditions change quickly,the use of biological indicators with short generation time such as diatoms is advantageous.This study combined geochemical and diatom data,whose results were highlighted in 3 groups:Group 1,with low p H(1.9–5.1)and high metal/metalloid(Al,As,Cd,Co,Cu,Fe,Mn,Ni,Pb,Zn;0.65–1032 mg/L)and SO_4(405–39124 mg/L)concentrations.An acidophilic species,Pinnularia aljustrelica,was perfectly adapted to the adverse conditions;in contrast,teratological forms of Eunotia exigua were found,showing that metal toxicity affected this species.The low availability of metals/metalloids in sediments of this group indicates that metals/metalloids of the exchangeable fractions had been solubilized,which in fact enables metal/metalloid diatom uptake and consequently the occurrence of teratologies;Group 2,with sites of near neutral p H(5.0–6.8)and intermediate metal/metalloid(0.002–6 mg/L)and SO_4(302–2179 mg/L)concentrations;this enabled the existence of typical species of uncontaminated streams(Brachysira neglectissima,Achnanthidium minutissimum);Group 3,with samples from unimpacted sites,showing low metal/metalloid(0–0.8 mg/L)and SO_4(10–315 mg/L)concentrations,high pH(7.0–8.4)and Cl contents(10–2119 mg/L)and the presence of brackish to marine species(Entomoneis paludosa).For similar conditions of acidity,differences in diversity,abundance and teratologies of diatoms can be explained by the levels of metals/metalloids. | Ana Teresa Luís Nuno Duraes SaloméFernandes Pinheiro de Almeida Eduardo Ferreira da Silva | 2016 | Journal of Environmental Sciences2016，28，4： | 4 |
| 5 | Complex hepatic outflow reconstruction in domino liver transplantation显示文摘Domino liver transplantation has been accepted as a safe procedure to further expand the organ donor pool. The most important technical challenge of the procedure resides in restoring a proper hepatic venous allograft outflow in the familial amyloidotic polyneuropathy-liver recipient. To overcome this issue, combined techniques were used to perform an innovative outflow reconstruction. A domino liver transplantation was successfully performed with reconstruction of complex venous outflow. The inferior vena cava sparing hepatectomy technique in the familial amyloidotic polyneuropathy-donor was used to cut the hepatic vein to the liver parenchyma. To overcome this issue the venous outflow tract was reconstructed using a longitudinally opened iliac vein graft from a post-mortem donor to create a new outflow tract using a diamond patch between the right and middle/left hepatic veins. | Rafael S Pinheiro Quirino Lai Carola Dahrenmoller Jan Lerut | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 2 |
| 6 | Photochemical responses and oxidative stress in the clones of Coffea canephora under water deficit conditions显示文摘 | Lima A L S DaMatta F M Pinheiro H A | 2002 | Environmental and Experimental Botany2002，47，23： | 1 |
| 7 | Photochemical responses and oxidative stress in two clones of Coffea canephora under water deficit conditions显示文摘 | LIMA A L S DAMATT F M PINHEIRO H A | 2002 | Environmental and Experimental Botany2002，47，： | 1 |
| 8 | Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippo campus of kainite-induced epileptic rats 显示文摘 | Silva AP Xapelli S Pinheiro PS | 2005 | J Neurochem2005，93，1： | 1 |
| 9 | 噻托溴铵的安全性考量显示文摘鉴于UPLIFT研究数据的有力支持,加之mata分析的统计学局限,FDA认为,目前的数据不支持经HandiHaler给药的噻托溴铵与脑卒中、心脏病或死亡风险的增加相关。 | Michele TM Pinheiro S Iyasu S 黄灿 | 2010 | 中国处方药2010，，9： | 1 |
| 10 | Duodenal-jejunal bypass for the treatment of type 2 diabetes in patients with body mass index of 22 ~ 34 kg/m2:a report of 2 cases显示文摘 | COHEN R V SCH1AVON C A PINHEIRO J S | 2007 | Surg Obes Relat Dis2007，3，2： | 1 |
| 11 | Prevalence and mechanisms of erythromycin resistance in Streptococcus agalactiae from healthy pregnant women显示文摘 | Pinheiro S Radhouani H Coelho C | 2009 | Microb Drug Resist2009，15，2： | 1 |
| 12 | The epitaxial growth of Pd electrodeposition on Au(100) studied by LEED and RHEED 显示文摘 | Pinheiro A L N Zei M S Luo M F | 2006 | Surface Science2006，600，： | 1 |
| 13 | Heat stress impairs performance and induces intestinal inflammation in broiler chickens infected with Salmonella Enteritidis显示文摘 | Quinteiro Filho W M Gomes A V S Pinheiro M L | 2012 | Avian Pa-thology2012，41，5： | 1 |
| 14 | Central nervous system Aspergillus fumigatus infection after near drowning显示文摘 | Kowacs PA Monteiro de Almeida S Pinheiro RL | | 0，，： | 1 |
| 15 | The stereoselective synthesis of nopinone based triazole ketones显示文摘 | Silva Junior R C Ferreira V F Pinheiro S | 2004 | Tetrahedron:Asymmetry2004，15，： | 1 |
| 16 | Extraction, purification and characterization of galactomannans from non-tradi- tional sources显示文摘 | Cerqueira M A Pinheiro A C Souza B W S | 2009 | Carbohydrate polymers2009，75，3： | 1 |
| 17 | High HIF-1α expression genotypes in oral lichen planus显示文摘 | Carlos Alberto Carvalho Fraga Lucas Rodrigues Alves Luciano Marques-Silva Adriana Alkmim Sousa Antonio Sérgio Barcala Jorge Sabrina Ferreira Jesus Daniel Nogueira Vilela Ugo Borges Pinheiro Kimberly Marie Jones Alfredo Maurício Batista Paula André Luiz Se | 2013 | Clinical Oral Investigations2013，，9： | 1 |
| 18 | Biphasic ethylene polymerization with a diimine nickel catalyst显示文摘 | Mauler R S de Souza R F | 2001 | Macromol Rapid Commun2001，22，6： | 1 |
| 19 | Genetic deletion of the angiotensin (1 7) receptor Mas leads to glomerular hyperfiltration and microalbu minuria显示文摘 | Pinheiro S V Ferreira A J Kitten G T da Silveira K D da Silva D A Santos S H | 2009 | Kidney Int2009，75，： | 1 |
| 20 | Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs 显示文摘 | Santos R A Ferreira A J Pinheiro S V | 2005 | Exp Opin Invest Drugs2005，14，8： | 1 |
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