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| 1 | Cerebrospinal fluid phosphorylated tau,visinin-like protein-1,and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease显示文摘Background:Visinin-like protein-1(VILIP-1)and chitinase-3-like protein 1(CHI3L1 or YKL-40)in cerebrospinal fluid(CSF)are newly discovered markers indicating neuronal damage and microglial activation,respectively.Phosphorylated tau(p-tau)reflects the neuropathology of Alzheimer’s disease(AD)and is useful as diagnostic markers for AD.However,it is unknown whether these biomarkers have similar or complementary information in AD.Methods:We stratified 121 participants from the Alzheimer’s Disease Neuroimaging Initiative(ADNI)database into cognitively normal(CN),stable mild cognitive impairment(sMCI),progressive MCI(pMCI),and dementia due to AD.Analysis of covariance(ANOVA)and chi-square analyses,Spearman correlation,and logistic regression models were performed to test the demographic,associations between biomarkers,and diagnostic accuracies,respectively.Linear mixed-effects models were used to evaluate the effects of CSF amyloid-β(Aβ)on above biomarkers within diagnostic groups,the combination of diagnostic group and Aβstatus as predictor,and CSF biomarkers as predictors of AD features,including cognition measured by Mini–Mental State Examination(MMSE)and brain structure and white matter hyperintensity(WMH)measured by magnetic resonance imaging(MRI).Results:P-tau,VILIP-1,and YKL-40 were all predictors of AD diagnosis,but combinations of biomarkers did not improve the diagnostic accuracy(AUC 0.924 for p-tau,VILIP-1,and YKL-40)compared to p-tau(AUC 0.922).P-tau and VILIP-1 were highly correlated(r=0.639,p<0.001)and strongly associated with Aβpathology across clinical stages of AD,while YKL-40 was correlated with Aβpathology in CN and AD groups.VILIP-1 was associated with acceleration of cognitive decline,hippocampal atrophy,and expansion of ventricles in longitudinal analyses.YKL-40 was associated with hippocampal atrophy at baseline and follow-up,while p-tau was only associated with worsening WMH at baseline.Conclusions:CSF levels of p-tau,VILIP-1,and YKL-40 may have utility for discriminating between cognitively normal subjects and patients with AD.Increased levels of both VILIP-1 and YKL-40 may be associated with disease degeneration.These CSF biomarkers should be considered for future assessment in the characterization of the natural history of AD. | Hua Zhang Kok Pin Ng Joseph Therriault Min Su Kang Tharick APascoal Pedro Rosa-Neto Serge Gauthier the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 2 | Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn’s Disease显示文摘 | Ingrid Ordás Jordi Rimola Sonia Rodríguez José M. Paredes María J. Martínez-Pérez Esther Blanc Juan A. Arévalo Marta Aduna Montserrat Andreu Alexander Radosevic Anna M. Ramírez-Morros Susana Pinó Marta Gallego Aranzazu Jauregui-Amezaga Elena Ricart Julián | 2013 | Gastroenterology2013，，： | 3 |
| 3 | l -Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer显示文摘 | Sílvia Busquets Roberto Serpe Míriam Toledo Angélica Betancourt Enrica Marmonti Marcel Orpí Fabrizio Pin Eva Capdevila Clelia Madeddu Francisco J. López-Soriano Giovanni Mantovani Antonio Macciò Josep M. Argilés | 2012 | Clinical Nutrition2012，，6： | 2 |
| 4 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 5 | Induction of heme oxygenase -1 by Ginkgo biloba in neuronal cultures and potential implications in ischemia 显示文摘 | Zhuang H Pin S Christen Y | 2002 | Cell Mol Biol2002，48，6： | 1 |
| 6 | Accuracy of three-Dimensional measurements using cone-beam CT 显示文摘 | Pinsky HM Dyda S Pin sky RW | 2006 | Dento maxillofac Radio2006，35，6： | 1 |
| 7 | Acute phage protein concentrantion are increased in Spain 显示文摘 | Segalé s J Pin eiro C Lampreave F | 2003 | Veterinary Record2003，146，： | 1 |
| 8 | an economic model of friendship~ homophily, minorities and segregation显示文摘 | Currarini S Jackson M O Pin P | 2009 | Econometrica2009，77，： | 1 |
| 9 | Induction of heme oxygenase-1 by Ginkgo biloba in neuronal cultures and potential implications in ischemia显示文摘 | Zhuang H Pin S Christen Y | 2002 | Cell Mol Biol2002，48，6： | 1 |
| 10 | A practical tool- kit for computational steering 显示文摘 | Pickles S M Haines R Pinning R L | 2005 | Philosophical Transac- tions of the Royal Society A: Mathematical Physical and Engineering Sciences''2005，363，1833： | 1 |
| 11 | Sequential separation of light rareearth elements,thorium and uranium by miniaturized extraction chromatography:Application to isotopic analyses of silicate rocks显示文摘 | Pin C Zalduegui J F S | 1997 | Analytica Chimica Acta1997，339，12： | 1 |
| 12 | The meshless finite element method 显示文摘 | Idelsohn S R Onate E Calvo N Del Pin F | 2003 | International Journal for Numerical Methods in Engineering2003，58，： | 1 |
| 13 | A single olfactory receptor specifically binds a set of odorant molecules显示文摘 | Gaillard I Rouquier S Pin J P | 2002 | European Journal of Neuroscience2002，15，3： | 1 |
| 14 | Identifying the roles of race-based choice and chance in high school friendship network formation显示文摘 | Currarini S Jackson M O Pin P | 2010 | Proceedings of the National Academy of Sciences2010，107，： | 1 |
| 15 | Congenital multifocal rhabdoid tumor: a case with peculiar biological behavior and different response to treatment according to location (central nervous system and kidney) 显示文摘 | Pin L Milanaccio C Maseelli S | 2014 | Cancer Genet2014，207，： | 1 |
| 16 | Expression of multiple larger-sized transcripts for several genes in oligodendrogliomas:potential markers for glioma subtype显示文摘 | Xu X Joh HD Pin S | 2001 | Cancer Lett2001，171，1： | 1 |
| 17 | A Lagrangian meshless finite element method applied to fluid-structure interaction problems 显示文摘 | Idelsohn S R Onate E Del Pin F | 2003 | Computers and Structures2003，81，： | 1 |
| 18 | Induction of heine oxygenase I by Ginkgo biloba in neuronal cultures and potential implica- tions in ischemia显示文摘 | Zhuang H Pin S Chinsten Y | 2002 | Cell Mol Biol (Noisy-le-grand) :2002，48，6： | 1 |
| 19 | Adding memory processing behavior to the fuzzy behaviorist approach: Resolving limit cycle problems in mobile robot navigation 显示文摘 | Pin F G Bender S R | 1999 | Intelligent Automation and Soft Computing1999，5，1： | 1 |
| 20 | cDNA cloning,substrate specificity and expression study of tobacco caffeoyl-CoA 3-O-methyltransferase,a lignin biosynthetic enzyme显示文摘 | Martz F Maury S Pin?on G | 1998 | Plant Molecular Biology1998，36，3： | 1 |
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