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| 1 | 应用CD83和HSF5鉴别生前与死后皮肤烧伤显示文摘目的探究白细胞分化抗原83(cluster of differentiation 83,CD83)和热休克转录因子5(heat shocktranscription factor 5,HSF5)鉴别生前、死后皮肤烧伤的法医学应用价值。方法通过逆转录实时定量聚合酶链反应(reverse transcription real-time quantitative polymerase chain reaction,RT-q PCR),定量检测生前及死后烧伤小鼠皮肤组织和人类皮肤组织中CD83和HSF5 m RNA的表达情况。结果与空白对照和死后烧伤组相比,生前烧伤组小鼠CD83和HSF5的m RNA水平明显升高,且死后96 h可检测CD83 m RNA高表达,死后72 h可检测HSF5 m RNA表达。15例人类烧伤皮肤和未烧伤自身皮肤相比,11例样本CD83和HSF5的m RNA水平在烧伤处升高(P<0.05),4例没有变化。结论CD83和HSP5有望作为生前烧伤鉴定的生活反应指标应用于法医学实践。 | 赵龙瑞 肖静 尚晴 李涛 刘新社 官方霖 | 2021 | 法医学杂志2021，37，5： | 0 |
| 2 | MiR-711 and miR-183-3p as potential markers for vital reaction of burned skin显示文摘In forensic practice,the identification of antemortem burns and postmortem burns is of the utmost importance.Reports from previous studies have shown that miRNAs,with lengths stretching over 18–25 nucleotides,are highly stable and resistant to degradation.However,there has been little research into the application of miRNAs in identifying antemortem and postmortem burns.This study compared the expression of miR-711 and miR-183-3p levels in mouse and postmortem human burned skins using RT-qPCR assay.RT-qPCR examination of burned mouse skins showed that increased miR-711 and miR-183-3p expression in comparison to intact skin tissues.The increased expressions of these two miRNAs were observed until 120 h after death in burned mouse skins,whereas no significant changes were found in postmortem burned skins.In human burned skins,the increased levels of these two miRNAs at 48 h following autopsy occurred in 19 of 26 subjects,which appeared to be related to the severity of the burn.These findings suggest that miR-711 and miR-183-3p may act as biomarkers for vital reaction of skin burn. | Kaikai Zhang Ming Cheng Jingtao Xu Lijian Chen Jiahao Li Qiangguo Li Xiaoli Xie Qi Wang | 2022 | Forensic Sciences Research2022，7，3： | 0 |
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