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| 1 | Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR显示文摘AIM:To investigate three isoforms of survivin in colorectal adenocarcinomas.METHODS:We used the LightCycler Technology(Roche),along with a common forward primer and reverse primers specific for the splice variants and two common hybridization probes labeled with fluorescein and LightCycler-Red fluorophore(LC-Red 640).Real time quantitative polymerase chain reaction(PCR) was performed on cDNAs from 52 tumor specimens from colorectal cancer patients and 10 unrelated normal colorectal tissues.In the patients group,carcinoembryonic antigen(CEA) and CA19-9 tumor markers were also measured immunochemically.RESULTS:Wild type survivin mRNA isoform was expressed in 48%of the 52 tumor samples,survivin-2b in 38%and survivin-ΔΕx3 in 29%,while no expression was found in normal tissues.The mRNA expression of wild type survivin presented a significant correlation with the expression of the ratio of survivin-2b,survivin-ΔΕx3,survivin-2b/wild type survivin and survivin-ΔΕx3/wild type survivin(P<0.001).The mRNA expression of wildsurvivin and survivin-ΔΕx3 was related with tumor size and invasion(P=0.006 and P<0.005,respectively).A significant difference was found between survivin-2b and morphologic cancer type.Also,the ratio of survivin-ΔEx3/ wild-survivin was significantly associated with prognosis.No association was observed between the three isoforms and grade,metastasis,Dukes stage and gender.The three isoforms were not correlated with CEA and CA19-9.CONCLUSION:Survivin isoforms may play a role in cell apoptosis and their quantification could provide information about clinical management of patients suffering from colorectal cancer. | Anastasia Pavlidou Maria Dalamaga Christos Kroupis George Konstantoudakis Maria Belimezi George Athanasas Kleanthi Dimas | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | Association of survivin splice variants with prognosis and treatment of breast cancer显示文摘The purpose of this study was the overview of current knowledge regarding the use of survivin and its isoforms in prognosis and treatment of breast cancer. An advanced search of Medline was performed using the following search strategy: '(survivin isoforms) OR(survivin transcript variants) AND(breast cancer) AND(neoplasm OR tumor OR cancer OR carcinoma)'. Relevant studies were retrieved and processed thoroughly in order to analyze the related data. Besides wild-type survivin full-length transcript, another six splice variants have been identified. Overexpression of survivin and its isoforms leads to shorter overall and disease-free survival; the transcript variants are correlated with apoptosis and could assist prognosis prediction. It has been proved through numerous studies that inhibiting survivin isoforms might become a promising target of drug therapy of carcinomas. Use of small molecule YM155 could offer new therapy for triple negative breast cancer patients, while, chemotherapy with 5-fluorouracil + epirubicin + cyclophosphamide and Tax-Epi could be guided by survivin splice variants measurements. Survivin transcript variants could become prognostic biomarkers and could provide information about clinical managementof patients suffering from breast cancer. | Anastasia Pavlidou Christos Kroupis Kleanthi Dimas | 2014 | World Journal of Clinical Oncology2014，5，5： | 6 |
| 3 | A review on polymer–layered silicate nanocomposites显示文摘 | S. Pavlidou C.D. Papaspyrides | 2008 | Progress in Polymer Science2008，，12： | 3 |
| 4 | Repeat endoscopic retrograde cholangiopancreaticography after failed initial precut sphincterotomy for biliary cannulation显示文摘AIM: To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography(ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation.METHODS: In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscopy and radiology reporting databases were analysed for use of precut sphincterotomy, biliary access rate, repeat ERCP rate and complications. Patients with initially failed precut sphincterotomy were identified.RESULTS: From 1839 consecutive ERCPs, 187(10%) patients underwent a precut sphincterotomy during the initial ERCP in attempts to cannulate a native papilla. The initial precut was successful in 79/187(42%). ERCP was repeated in 89/108(82%) of patients with failed initial precut sphincterotomy after a median interval of 4 d, leading to successful biliary cannulation in 69/89(78%). In 5 patients a third ERCP was attempted(successful in 4 cases). Overall, repeat ERCP after failed precut at the index ERCP was successful in 73/89 patients(82%). Complications after precut-sphincterotomy were observed in 32/187(17%) patients including pancreatitis(13%), retroperitoneal perforations(1%), biliary sepsis(0.5%) and haemorrhage(3%).CONCLUSION: The high success rate of biliary cannulation in a second attempt ERCP justifies repeating ERCP within 2-7 d after unsuccessful precut sphincterotomy before more invasive approaches should be considered. | Michael Pavlides Ashley Barnabas Nilesh Fernandopulle Adam A Bailey Jane Collier Jane Phillips-Hughes Anthony Ellis Roger Chapman Barbara Braden | 2014 | World Journal of Gastroenterology2014，20，36： | 3 |
| 5 | Emerging artificial intelligence applications in liver magnetic resonance imaging显示文摘Chronic liver diseases(CLDs)are becoming increasingly more prevalent in modern society.The use of imaging techniques for early detection,such as magnetic resonance imaging(MRI),is crucial in reducing the impact of these diseases on healthcare systems.Artificial intelligence(AI)algorithms have been shown over the past decade to excel at image-based analysis tasks such as detection and segmentation.When applied to liver MRI,they have the potential to improve clinical decision making,and increase throughput by automating analyses.With Liver diseases becoming more prevalent in society,the need to implement these techniques to utilize liver MRI to its full potential,is paramount.In this review,we report on the current methods and applications of AI methods in liver MRI,with a focus on machine learning and deep learning methods.We assess four main themes of segmentation,classification,image synthesis and artefact detection,and their respective potential in liver MRI and the wider clinic.We provide a brief explanation of some of the algorithms used and explore the current challenges affecting the field.Though there are many hurdles to overcome in implementing AI methods in the clinic,we conclude that AI methods have the potential to positively aid healthcare professionals for years to come. | Charles E Hill Luca Biasiolli Matthew D Robson Vicente Grau Michael Pavlides | 2021 | World Journal of Gastroenterology2021，27，40： | 2 |
| 6 | Evolving role of magnetic resonance techniques in primary sclerosing cholangitis显示文摘Development of non-invasive methods to risk-stratify patients and predict clinical endpoints have been identified as one of the key research priorities in primary sclerosing cholangitis(PSC). In addition to serum and histological biomarkers, there has been much recent interest in developing imaging biomarkers that can predict disease course and clinical outcomes in PSC.Magnetic resonance imaging/magnetic resonance cholangiopancreatography(MRI/MRCP) continue to play a central role in the diagnosis and follow-up of PSC patients. Magnetic resonance(MR) techniques have undergone significant advancement over the last three decades both in MR data acquisition and interpretation. The progression from a qualitative to quantitative approach in MR acquisition techniques and data interpretation, offers the opportunity for the development of objective and reproducible imaging biomarkers that can potentially be incorporated as an additional endpoint in clinical trials. This review article will discuss how the role of MR techniques have evolved over the last three decades from emerging as an alternative diagnostic tool to endoscopic retrograde cholangiopancreatography, to being instrumental in the ongoing search for imaging biomarker of disease stage, progression and prognosis in PSC. | Emmanuel A Selvaraj Emma L Culver Helen Bungay Adam Bailey Roger W Chapman Michael Pavlides | 2019 | World Journal of Gastroenterology2019，25，6： | 2 |
| 7 | Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease显示文摘 | Rajarshi Banerjee Michael Pavlides Elizabeth M. Tunnicliffe Stefan K. Piechnik Nikita Sarania Rachel Philips Jane D. Collier Jonathan C. Booth Jurgen E. Schneider Lai Mun Wang David W. Delaney Ken A. Fleming Matthew D. Robson Eleanor Barnes Stefan Neubaue | 2014 | Journal of Hepatology2014，，1： | 2 |
| 8 | The Role of High Altitude Platforms in beyond 3G Networks 显示文摘 | Stylianos Karapantazis Fotini-Niovi Pavlidou | 2005 | IEEE Wireless Communications (S1536-1276)2005，12，： | 1 |
| 9 | Page segmnentation and classification显示文摘 | J Zhou | 1992 | Computer Vi sion Graphics and Image Processing1992，，48： | 1 |
| 10 | Satellite handover techniques for LEO networks显示文摘 | Papapetrou E Karapantazis S Dimitriadis G and Pavlidou F | 2004 | International Journal of Satellite Communications and Networking2004，22，2： | 1 |
| 11 | Potential oscillations induced by localized corrosion of the passivity on iron in halide- containing sulfuric acid media as a probe for a comparative study of the halide effect显示文摘 | Sazou D Pavlidou M Pagitsas M | 2012 | J Electroanal Chem2012，675，： | 1 |
| 12 | Bar Code Waveform Recognition Using Peak Locations显示文摘 | Pavlids T | 1994 | IEEE Trans PAMI1994，16，6： | 1 |
| 13 | Effect of Ti, Ni and Bi addition to the corrosion resistance of Zn hot-dip galvanized coatings显示文摘 | Pistofidis N Vourlias G Pavlidou E | 2007 | Journal of Optoelectronics and Advanced Materials2007，9，6： | 1 |
| 14 | Predictors of long term event free survival after percutaneous balloon mitral valvuloplasty显示文摘 | Nahhas GT London J | 1997 | Am J Cardiol1997，79，： | 1 |
| 15 | Caveolin-1 and regulation of cellular cholesterol homeostasis显示文摘 | Frank P G Cheung M W Pavlides S | 2006 | Am J Physiol Heart Circ Physiol2006，291，2： | 1 |
| 16 | A review on polymer- layered silicate nanocomposites显示文摘 | Pavlidou S Papaspyrides C D | 2008 | Progress in Poly- mer Science2008，33，12： | 1 |
| 17 | JNKI stress signaling is hyper-activated in high breast density and the tumor stroma: Con- necting fibrosis, inflammation, and sternness fnr cancer prevention 显示文摘 | I isanti MP Tsirigos A Pavlides S | 2014 | Cell Cycle2014，13，4： | 1 |
| 18 | The combined effect of nickel and bismuth on the structure of hot-dip zinc coatings 显示文摘 | PISTOFIDIS N VOURLIAS G KONIDARIS S PAVLIDOU EL STERGIOUDIS G | 2007 | Mater Lett2007，61，： | 1 |
| 19 | Caveolin-1 and regulation of cellular cholesterol homeostasis 显示文摘 | Frank PG Cheung MW Pavlides S | 2006 | Am J Physiol Heart Circ Physiol2006，291，2： | 1 |
| 20 | Predictors of long-term event-free survival after percutaneous balloon mitral valvuloplasty 显示文摘 | Pavlides GS Nahhas GT London J | 1997 | Am J Cardiol1997，79，： | 1 |
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