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| 1 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 2 | Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity显示文摘AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Paracellular hyperpermeability was induced in Caco2.BBE and HT-29CL.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were studied.An inhibitor of glutamate transport(L-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were used.RESULTS:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,P<0.001).Glutamine application reduced hyperpermeability by 19%and 39%in the respective cell lines.Glutamate application reduced hyperpermeability by 30%and 20%,respectively.Incubation of HT29CL.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability levels.Incubation of Caco2.BBE cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability levels.CONCLUSION:Apical glutamate-similar to glutaminecan decrease induced paracellular hyperpermeability.Extracellular conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine. | Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van Leeuwen Alexander PJ Houdijk | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 3 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 4 | Mice lacking connex in40 have cardiac conduction abnormalities characteristic of at rioventricular block and bundle branch block显示文摘 | Simon AM Goodenough DA Paul DL | 1998 | Curr Boil1998，8，5： | 1 |
| 5 | Identification of DIBLO,a mammalian protein that promotes by binding to and antagonizing IAP proteins显示文摘 | Paul GE Pakusch M | 2000 | Cell2000，102，1： | 1 |
| 6 | Inducing differentiation of tramsformed cells with hybrid polar compounds: a cell cycle-dependent process 显示文摘 | Paul AM Victoria MR Hiroaki K | 1994 | PNAS1994，91，10： | 1 |
| 7 | Histone deacetylases显示文摘 | Paul AM Thomas M Victoria MR | 2003 | Curr Opin Pharmacol2003，3，4： | 1 |
| 8 | Preexisting conditions and mortality in older trauma patients 显示文摘 | Gerald McG Paul AM Jessaka BF | 2004 | J Trauma2004，56，6： | 1 |
| 9 | Agrobacterium-mediated transformation as a tool for functional genomics in fungi 显示文摘 | CAROLINE B M PAUL JJH CEES AM J | 2005 | Current Genet2005，48，1： | 1 |
| 10 | Effects of micronization on digestive adsorption of diosmin显示文摘 | Johnsyon AM Paul HJ Young CG | | 0，，01： | 1 |
| 11 | Effects of micronization on diges-tive adsorption of diosmin显示文摘 | Johnsyon AM Paul HJ Young CG | 1994 | Phlebology1994，1，2： | 1 |
| 12 | Niacinamide blocks 3- acetylpyridine toxicity of cerebellar granule cells in vitro显示文摘 | Weller M Marini AM Paul SM | 1992 | Brain Res1992，594，1： | 1 |
| 13 | Histone deacetylases and cancer: causes and therapies 显示文摘 | Paul AM Richard AR VictoriaMR | 2001 | Nat Reviews Cancer2001，1，12： | 1 |
| 14 | Comparative analysis of cost of endoscopic endonasal minimally invasive and sublabiahransseptal approaches to the pituitary 显示文摘 | OOSMANALLY N PAUL JE ZANATION AM | 2011 | Int Forum Al- lergy Rhinol2011，1，4： | 1 |
| 15 | Spinal Cord and Intradural-Extraparenchymal Spinal Tumors: Current Best Care Practices and Strategies显示文摘 | Andrew T. Parsa Janet Lee Ian F. Parney Philip Weinstein Paul C. McCormick Christopher Ames | 2004 | Journal of Neuro - Oncology (-)2004，，1： | 1 |
| 16 | Mice lacking oonnexin40have cardiac conduction abnormalities chauacteristic of atrioventricular block and bundle branch block显示文摘 | Simon AM Goodenough DA Paul DL | 1998 | Curr Biol1998，8，5： | 1 |
| 17 | Mice lacking connexin 40have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block显示文摘 | Simon AM Goodenough DA Paul DL | 1998 | Curr Biol1998，8，5： | 1 |
| 18 | Laparoscopic surgery in the treatment of Mirizzi's syndrome显示文摘 | Paul MG Burns DG McGiure AM | 1992 | J Laparoendosc Surg1992，2，： | 1 |
| 19 | Root development and absorption of ammonium and nitrate from the rhizo- sphere 显示文摘 | Arnold JB Paul AM Alison RT | 2003 | Plant Growth Regul2003，21，： | 1 |
| 20 | Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients显示文摘AIM:To analyze the change of dimethylarginine plasma levels in cirrhotic patients receiving transjugular intrahepatic portosystemic shunt(TIPS).METHODS:To determine arginine,asymmetric dimethylarginine(ADMA),symmetric dimethylarginine(SDMA),and nitric oxide(NO) plasma levels,blood samples were collected from the superior cava,hepatic,and portal vein just before,directly after,and 3 mo after TIPS-placement.RESULTS:A significant increase in the arginine/ADMA ratio after TIPS placement was shown.Moreover,TIPS placement enhanced renal function and thereby decreased systemic SDMA levels.In patients with renal dysfunction before TIPS placement,both the arginine/ADMA ratio and creatinine clearance rate increased significantly,while this was not the case in patients with normal renal function before TIPS placement.Hepatic function did not change significantly after TIPS placement and no significant decline in ADMA plasma levels was measured.CONCLUSION:The increase of the arginine/ADMA ratio after TIPS placement suggests an increase in intracellular NO bioavailability.In addition,this study suggests that TIPS placement does not alter dimethylarginine dimethylaminohydrolase(DDAH) activity and confirms the major role of the liver as an ADMA clearing organ. | Michiel PC Siroen Reiner Wiest Milan C Richir Tom Teerlink Jan A Rauwerda Friedrich T Drescher Niels Zorger Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，47： | 1 |
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