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| 1 | Inflammatory role of the acinar cells during acute pancreatitis显示文摘Pancreatic acinar cells are secretory cells whose main function is to synthesize, store and f inally release digestive enzymes into the duodenum. However, in response to noxious stimuli, acinar cells behave like real inflammatory cells because of their ability to activate signalling transduction pathways involved in the expression of inflammatory mediators. Mediated by the kinase cascade, activation of Nuclear factor-κB, Activating factor-1 and Signal transducers and activators of transcription transcription factors has been demonstrated in acinar cells, resulting in overexpression of inflammatory genes. In turn, kinase activity is down-regulated by protein phosphatases and the f inal balance between kinase and phosphatase activity will determine the capability of the acinar cells to produce inflammatory factors. The kinase/ phosphatase pair is a redox-sensitive system in which kinase activation overwhelms phosphatase activity under oxidant conditions. Thus, the oxidative stress developed within acinar cells at early stages of acute pancreatitis triggers the activation of signalling pathways involved in the up-regulation of cytokines, chemokines and adhesion molecules. In this way, acinar cells trigger the release of the f irst inflammatory signals which can mediate the activation and recruitment of circulating inflammatorycells into the injured pancreas. Accordingly, the role of acinar cells as promoters of the inflammatory response in acute pancreatitis may be considered. This concept leads to amplifying the focus from leukocyte to acinar cells themselves, to explain the local inflammation in early pancreatitis. | Isabel De Dios | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，1： | 11 |
| 2 | Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor显示文摘Approximately 10% of patients with gastrointestinal stromal tumors (GIST) develop other neoplasms, either synchronously or metachronously. In this report we describe coexistence of a gastrointestinal stromal tumor and a hepatic perivascular epithelioid cell tumor (PEComa) in a 51-year-old woman with no evidence of tuberous sclerosis. A subcapsular hepatic nodule (0.8 cm in diameter) was found during surgery for symptomatic gastric neoplasm (15 cm in diameter) arising from the lesser curvature. Both tumors revealed histomorphological and immunohistochemical features confirming a diagnosis of a small incidental hepatic PEComa and a high risky extramural gastric GIST, respectively. The patient remained disease-free 25 mo after surgery with no evidence of tumor recurrence or new neoplasms. To our knowledge, this is the first report of PEComa in a patient with GIST. Hepatic lesions detected synchronously or metachronously in patients with GISTs may represent histogenetically distinct lesions and should be sampled to confirm or exclude metastatic GISTs. | Carlos Eduardo Paiva Francisco Alves Moraes Neto Abbas Agaimy Maria Aparecida Custódio Domingues Silvia Regina Rogatto | 2008 | World Journal of Gastroenterology2008，14，5： | 6 |
| 3 | Interplay between HEAT SHOCK PROTEIN 90 and HY5 Controls PhANG Expression in Response to the GUN5 Plastid Signal显示文摘把 organellar 蛋白质编码为不同细胞的分隔空间的基因的存在由真核细胞的房间的不同染色体要求表示的紧密的协作。基因表示的这协作被 organelle-to-nucleus 完成或后退通讯。tetrapyrrole 小径的导致压力的不安在植物在原子基因表示触发大变化。最近,我们作为通常认为的质体信号 Mg-ProtoIX 的 ligands 识别了 HSP90 蛋白质。以便调查在 HSP90 和 Mg-ProtoIX 之间的相互作用是否是生物学上相关的,我们与 cytosolic HSP90 的减少的层次生产了转基因的线在野类型并且 gun5 背景。我们的工作揭示蛋白质回答到调停 tetrapyrrole 的质体信号在对氧化应力的反应期间控制联系光合作用的原子基因(PhANG ) 的表示的那 HSP90。我们也证明 hy5 异种对 tetrapyrrole 累积感觉迟钝并且 Mg-ProtoIX, cytosolic HSP90,和 HY5 都是一样的发信号小径的部分。这些调查结果建议包括 HSP90 蛋白质和被 tetrapyrroles 修改响应的一个抄写因素的规章的复杂控制基因表情在环境变化 evolutionarily 在酵母和工厂之间被保存。 | Peter Kindgren Louise Noren Juan de Dios Barajas Lopez Jehad Shaikhali Asa Strand | 2012 | Molecular Plant2012，5，4： | 4 |
| 4 | Hepatitis B vaccine in celiac disease:Yesterday,today and tomorrow显示文摘Some studies showed that in celiac patients the immunological response to vaccination is similar to that one found in general population except for vaccine against hepatitis B virus (HBV).The non-responsiveness to HBV vaccine has also been described in healthy people,nevertheless the number of non-responders has been demonstrated to be higher in celiac disease (CD) patients than in healthy controls.Several hypothesis explaining this higher rate of unresponsiveness to HBV vaccine in CD patients have been described,such as the genetic hypothesis,according with CD patients carrying the disease-specific haplotype HLA-B8,DR3,and DQ2,show a lower response to HBV vaccine both in clinical expressed CD patients and in healthy people carrying the same haplotype.On the other hand,it has been demonstrated that the gluten intake during the vaccination seems to influence the response to the same vaccine.Moreover,it has been demonstrated a possible genetic predisposition to hepatitis B vaccine nonresponsiveness likely due to the presence of specific human leukocyte antigen haplotypes and specific single nucleotide polymorphism in genes of cytokine/cytokinereceptors and toll like receptors,but the pathogenic mechanism responsible for this low responsiveness still remains unclear.The aim of this review is to focus on the possible pathogenic causes of unresponsiveness to HBV vaccine in CD patients and to propose an alternative vaccination schedule in order to improve the responsiveness to HBV vaccine in this at-risk patients. | Giovanna Vitaliti Andrea Domenico Praticò Carla Cimino Giovanna Di Dio Elena Lionetti Mario La Rosa Salvatore Leonardi | 2013 | World Journal of Gastroenterology2013，19，6： | 3 |
| 5 | Nanovesicles Are Secreted during Pollen Germination and Pollen Tube Growth: A Possible Role in Fertilization显示文摘Dear Editor, During recent decades,a novel mechanism of secretion has been identified in a wide range of mammalian cells.It involves the release of bioactive membrane nanovesicles (30-100 nm),termed exosomes,upon the fusion of multivesicular bodies with the plasma membrane (Théry et al.,2009).Exosomes are implicated in diverse functions,such as scavenging of archaic proteins,intercellular messengers delivering cell-specific signals,and vehicles for transmissible pathogens.Exosomes have also been described in other organisms such as bacteria,Drosophila,and fungi. | Noela Prado Juan de Dios Alche Juan Casado-Vela Salvador Mas Mayte Villalba Rosalia Rodriguez Eva Batanero | 2014 | Molecular Plant2014，7，3： | 3 |
| 6 | GOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer显示文摘Non-small cell lung cancer(NSCLC) is a heterogeneous disease accounting for approximately 85% of all lung cancers. Only 17% of patients are diagnosed at an early stage. Treatment is multidisciplinary and radiotherapy plays a key role in all stages of the disease. More than 50% of patients with NSCLC are treated with radiotherapy(curative-intent or palliative). Technological advancesincluding highly conformal radiotherapy techniques, new immobilization and respiratory control systems, and precision image verification systems-allow clinicians to individualize treatment to maximize tumor control while minimizing treatment-related toxicity. Novel therapeutic regimens such as moderate hypofractionation and advanced techniques such as stereotactic body radiotherapy(SBRT) have reduced the number of radiotherapy sessions. The integration of SBRT into routine clinical practice has radically altered treatment of early-stage disease. SBRT also plays an increasingly important role in oligometastatic disease. The aim of the present guidelines is to review the role of radiotherapy in the treatment of localized, locally-advanced, and metastatic NSCLC. We review the main radiotherapy techniques and clarify the role of radiotherapy in routine clinical practice. These guidelines are based on the best available evidence. The level and grade of evidence supporting each recommendation is provided. | Nuria Rodriguez De Dios Arturo Navarro-Martin Cristina Cigarral Rodolfo Chicas-Sett Rafael Garcia Virginia Garcia Jose Antonio Gonzalez Susana Gonzalo Mauricio Murcia-Mejia Rogelio Robaina Amalia Sotoca Carmen Vallejo German Valtuena Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，4： | 2 |
| 7 | Detection of non-alcoholic steatohepatitis in patients with morbid obesity before bariatric surgery: preliminary evaluation with acoustic radiation force impulse imaging显示文摘 | F. Guzmán-Aroca M. D. Frutos-Bernal A. Bas J. A. Luján-Mompeán M. Reus Juan Dios Berná-Serna P. Parrilla | 2012 | European Radiology2012，，11： | 2 |
| 8 | An update on infective endocarditis of dental origin显示文摘 | Carmona I T Dios P D Posse J L | 2002 | J Dent2002，30，： | 1 |
| 9 | Down syn- drome: Lip lesionS (angular stomatitis and fissures ) and Candida albicans显示文摘 | Sculty C van Bruggen W Diz Dios P | 2002 | Br J Dermatol2002，147，1： | 1 |
| 10 | Khin M M,Physiologie specialization of pyricularia oryzae in philippines显示文摘 | Bonman J M Vergel de Dios T I | 1986 | Plant Disease1986，70，： | 1 |
| 11 | Aneurysmal bone cyst: a clinicopatholigic study of 238 cases 显示文摘 | Vergel De Dios A M Bond J R Shires T C | 1992 | Cancer1992，69，： | 1 |
| 12 | Time spent with symptoms in a cohort of bipolar disorder outpatients in Spain:a prospective,18-month follow-up study显示文摘 | De Dios C Ezquiaga E Garcia A | 2010 | J Affect Disord2010，125，13： | 1 |
| 13 | The tautomerase active site of macrophage migrationinhibitory factor is a potential target for discovery of novel anti-inflammatory agents显示文摘 | Lubetsky J B Dios A Han J Aljabari B Ruzsicska B MitchellR | 2002 | J Biol Chem2002，277，24： | 1 |
| 14 | Proliferation and differentiation of a human colon cancer cell line (CaCO2) in associated with significant changes in the expression of insulin-like growth factor(IGF) Ⅱ and IGF binding protein 4:role of IGF-Ⅱ显示文摘 | Singh P Dio B Yarapedlj U | 1996 | Endocrinology1996，137，5： | 1 |
| 15 | Critically ill patients with cancer: A clinical perspective显示文摘Cancer patients account for 15%of all admissions to intensive care unit(ICU)and 5%will experience a critical illness resulting in ICU admission.Mortality rates have decreased during the last decades because of new anticancer therapies and advanced organ support methods.Since early critical care and organ support is associated with improved survival,timely identification of the onset of clinical signs indicating critical illness is crucial to avoid delaying.This article focused on relevant and current information on epidemiology,diagnosis,and treatment of the main clinical disorders experienced by critically ill cancer patients. | Frank Daniel Martos-Benítez Caridad de Dios Soler-Morejón Karla Ximena Lara-Ponce Versis Orama-Requejo DailéBurgos-Aragüez Hilev Larrondo-Muguercia Rahim W Lespoir | 2020 | World Journal of Clinical Oncology2020，11，10： | 1 |
| 16 | Prevalence of air bron-chograms in small perpheral carcinomas of the lung on thin-section CT,comparison with benign tumors显示文摘 | Kuriyama K Tateishi R Dio O | 1991 | AJR1991，156，5： | 1 |
| 17 | Combined QT interval and voltage criteria improve left ventricular hypertrophy detection in resistant hypertension显示文摘 | Salles G Leocádio S Bloch K | 2005 | Hypertension2005，46，： | 1 |
| 18 | Performance of quantitative ultrasound in the discrimination of prevalent osteoporotic fractures in a bone metabolic unit显示文摘 | Lopez-Rodriguez F Mezquita-Raya P de Dios Luna J | 2003 | Bone2003，32，： | 1 |
| 19 | An update on the controversies in bacterial endocarditis of oral origin显示文摘 | Carmona IT Dios PD Scully C | 2002 | Oral Surg Oral Med Oral Pathol2002，93，： | 1 |
| 20 | The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents显示文摘 | Lubetsky JB Dios A Han J | 2002 | J Biol Chem2002，277，24： | 1 |
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