|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications显示文摘Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects. | MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 2 | Prognostic value of epidermal growth factor receptors in gastric cancer: a survival analysis by Weibull model incorporating long-term survivors显示文摘 | Alexandre Andrade Anjos Jácome Durval R. Wohnrath Cristovam Scapulatempo Neto Estela C. Carneseca Sérgio V. Serrano Luciano Souza Viana Jo?o S. Nunes Edson Z. Martinez José Sebasti?o Santos | 2014 | Gastric Cancer2014，，1： | 2 |
| 3 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavoudngs显示文摘 | MARTINEZ O SALMERON L GUILLEN M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 4 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavourings显示文摘 | Martinez O Salmeron J Guillen M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 5 | Grating and prism compressor in the case of finite beam size显示文摘 | Martinez O E | 1986 | J Opt Soc Am B1986，3，7： | 1 |
| 6 | Modeling the reduction of pectin methyl esterase activity in orange juice by high intensity pulsed electric field 显示文摘 | Elez- Martinez P Sudrez- Recio M Martin- Belloso O | 2007 | Journal of Food Engineering2007，78，1： | 1 |
| 7 | Early up-regulation of Th2cytokines and late surge of Th1cytokines in an aopic dermatitis model显示文摘 | Chen L Martinez O Ovebergh L | 2004 | Clin Exp Immunol2004，138，3： | 1 |
| 8 | Aluminium anodisation for Au-CeO2/Al2O3-AI monoliths preparation显示文摘 | Sanz O Martinez L M Echave F J | 2009 | Chemical Engineering Journal2009，151，13： | 1 |
| 9 | Induction of settlement and metamorphosis of the scallop Argopecten purpuratus Larmark by excess K^+ and epinephrine:energetic costs显示文摘 | Martinez G Aguilera C Caropos E O | 1999 | J Shellfish Res1999，18，： | 1 |
| 10 | Dynamic and static hysteresis in crayfish receptors显示文摘 | SEGUNDO J P MARTINEZ O D | 1985 | Biol Cybern1985，52，5： | 1 |
| 11 | Effect of selected aldehydes on the growth and fermentation of ethanologenic Escherichia coli 显示文摘 | Zaldivar J Martinez A Ingram L O | 1999 | Biotechnol Bioeng1999，65，： | 1 |
| 12 | Tumour necrosis factor alpha and troponin T as predictors of poor prognosis in patients with stable heart failure 显示文摘 | Rodriguez-Reyna TS Arrieta O Castilo - Martinez L | 2005 | Clin Invest Med2005，28，1： | 1 |
| 13 | Optimization of the shear strengths of ultrasonically consolidated Ti/AI 3003 dual-material structures显示文摘 | Obielodan J O Stucker B E Martinez E | 2011 | Journal of Materials Processing Technology2011，，6： | 1 |
| 14 | 3D beamforming with ultrasonic divided ring arrays显示文摘 | ULLATE L G MARTINEZ O PARRILLA M | 2002 | Ultrasoincs2002，40，1： | 1 |
| 15 | Estrogen receptor-Alpha methylation predicts melanoma progression显示文摘 | Mori T Martinez S R O'Day S J | 2006 | Cancer Res2006，66，13： | 1 |
| 16 | Automatic thermographic and RGB texture of as-built BIM for energy rehabilitation purposes显示文摘 | Lagüela S Díaz-Vilari(n)o L Martinez J | | 0，，： | 1 |
| 17 | Compact system for high-speed velocimetry using heterodyne tech- niques显示文摘 | Strand O T Goosman D R Martinez C | 2006 | Review of Scientific Instruments2006，77，08： | 1 |
| 18 | Texture profile analysis of meat products treated with commercial liquid smoke flavourings显示文摘 | Martinez O Salmeron J Guillen M D | | 0，，06： | 1 |
| 19 | Comparison of metabolic effects of arip- iprazole,quetiapine and ziprasidone after 12 weeks of treatment in first treated episode of psychosis 显示文摘 | Perez -Iglesias R Ortiz -Garciade la Foz V Martinez Garcia O | 2014 | Schizophr Res2014，159，1： | 1 |
| 20 | Biodesulphurisation of coal by microorganisms isolated from the coal itseli显示文摘 | Aller A Martinez O Linaje J A | 2001 | Fuel Processing Technology2001，69，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员