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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 4 | Mechanical properties and oxidation behavior of Ti-Si-N films prepared by plasma-assisted CVD显示文摘 | Kim K H Park B H | 1999 | Adv Mater1999，11，7： | 2 |
| 5 | O′- zirconia and its refractory application显示文摘 | HOGGARD D B PARK Han K | 1990 | Am Ceram Soc Bull1990，69，7： | 2 |
| 6 | The effect of talc on cell nucleation in extrusion foam processing of polypropylene with CO2 and isopentane显示文摘 | Park C B Cheung L K Song S W | 1998 | Cellular Polymers1998，17，4： | 2 |
| 7 | O′-zirconia and its refractory application显示文摘 | HOOGGARD D B PARK H K | 1990 | Am Ceram Soc Bull1990，69，7： | 2 |
| 8 | The gas separation properties of carbon molecular sieve membranes derived from polyimides having carboxylic acid groups显示文摘 | Kim Y K Lee J M Park H B | 2004 | Journal of Membrane Science2004，235，： | 1 |
| 9 | 显示文摘 | Jung K Y Park S B | 1999 | J Photochem Photobiol A Chem1999，127，： | 1 |
| 10 | 显示文摘 | Kweon D K Song S B Park Y Y | 2003 | Biomaterials2003，24，： | 1 |
| 11 | Lesion localization in patients with a previous negative transrectal ultrasound biopsy and persistently elevated prostate specific antigen level using diffusion-weighted imaging at three Tesla before rebiopsy显示文摘 | Park B K Lee H M Kim C K | 2008 | Invest Radiol2008，43，11： | 1 |
| 12 | A study on eyelid localization considering image focus for iris recognition显示文摘 | JANG Y KANG B PARK K | 2008 | Pattern Recognition Letters2008，29，11： | 1 |
| 13 | Overexpression of phos- pholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Spl-mediated signaling pathways显示文摘 | Park M H Ahn B H Hong Y K | 2009 | Carcino- genesis2009，30，2： | 1 |
| 14 | Surface plasmon resonance immunosensor for the detection of Salmonella typhimurium 显示文摘 | OH B K KIM Y K PARK K W | 2004 | Biosens Bioelectron2004，19，11： | 1 |
| 15 | Effect of the addition of Ag on the strengthening of Al3 Li phase in Al-Li single crystals显示文摘 | Lee B C Park J K | 1998 | Acta Mater1998，46，： | 1 |
| 16 | Contour parallel offset machining without tool-retractions 显示文摘 | Park S C Chung Y C Choi B K | 2003 | Computer-Aided Design2003，35，9： | 1 |
| 17 | Galactosylated chitosan-graft-dextran as hepatocyte-targeting DNA carrier 显示文摘 | Park Y K Park Y H Shin B A | 2000 | Journal of Controlled Release2000，69，： | 1 |
| 18 | Hepatitis C Virus NS5B Protein is a Membrane-associated Phosphoprotein with a Prodiminantly Perinuclear Localizatin显示文摘 | Hwang S B Park K J Kim Y S | 1997 | Virology1997，227，： | 1 |
| 19 | A particle swarm optimization for economic dispatch with nonsmooth cost functions 显示文摘 | J B Park K S Lee J R Shin | 2005 | IEEE Transactions on Power Systems2005，20，1： | 1 |
| 20 | Reflective mode of HPDLC with various structures of polyurethane acrylates显示文摘 | PARK M S KIM B K KIM J C | 2003 | Polymer2003，44，5： | 1 |
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