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| 1 | Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients显示文摘The incidence of gram-negative multidrug-resistant(MDR) bacterial pathogens is increasing in hospitals and particularly in the intensive care unit(ICU) setting. The clinical consequences of infections caused by MDR pathogens remain controversial. The purpose of this review is to summarize the available data concerning the impact of these infections on mortality in ICU patients. Twenty-four studies, conducted exclusively in ICU patients, were identified through Pub Med search over the years 2000-2015. Bloodstream infection was the only infection examined in eight studies, respiratory infections in four and variable infections in others. Comparative data on the appropriateness of empirical antibiotic treatment were provided by only seven studies. In ten studies the presence of antimicrobial resistance was not associated with increased mortality; on the contrary, in other studies a significant impact of antibiotic resistance on mortality was found, though, sometimes, mediated by inappropriate antimicrobial treatment. Therefore, a direct association between infections due to gram-negative MDR bacteria and mortality in ICU patients cannot be confirmed. Sample size, presence of multiple confounders and other methodological issues may influence the results. These data support the need for further studies to elucidate the real impact of infections caused by resistant bacteria in ICU patients. | Elisabeth Paramythiotou Christina Routsi | 2016 | World Journal of Critical Care Medicine2016，5，2： | 3 |
| 2 | Tigecycline in the treatmentof infections from multi-drug resistant gram-nega- tive pathogens 显示文摘 | Poulakou G Kontopidou FV Paramythiotou E | 2009 | Infect2009，58，4： | 1 |
| 3 | Acquisition of multidrug resistant Pseudomonas aeruginosa in patients in intensive care units:role of antibiotics with antipseudomonal activity显示文摘 | Paramythiotou E Lucet JC Timsit JF | 2004 | Clin Infect Dis2004，38，： | 1 |
| 4 | Acquisition of multiresis-tant Pseudomona aeruginosa in patients in intensive care units:role of antibiotics with antipseudomonal activity显示文摘 | Paramythiotou E Lueet jc Timsit JF | 2004 | Clin Infect Dis2004，38，5： | 1 |
| 5 | Tigecy- cline in the treatment of infections from multi-drug resistant gram-negative pathogens显示文摘 | Poulakou G Kontopidou FV Paramythiotou E | 2009 | J Infect2009，58，4： | 1 |
| 6 | Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens显示文摘 | Poulakou G Kontopidou F V Paramythiotou E | 2009 | J Infect2009，58，4： | 1 |
| 7 | Acquisition of multidrug-resistant Pseudomonsa aeruginosa in patients in intensive care units: role of antibiotics with antipseudomonal activity 显示文摘 | Paramythiotou E Lucet J C Timsit J F | 2004 | Clin Infect Dis2004，38，5： | 1 |
| 8 | Invasive fungal infections in the ICU: how to approach, how to treat 显示文摘 | Paramythiotou E Frantzeskaki F Flevari A | 2014 | Molecules2014，19，1： | 1 |
| 9 | Acquisition ofmultidrug-resistantPseudomonas aeruginosain patients in intensive care units:role of antibiotics with antipseudomonal activity显示文摘 | Paramythiotou E Lucet JC Timsit JF | 2004 | Clin Infect Dis2004，38，2： | 1 |
| 10 | Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens显示文摘 | Poulakou G Kontopidou F V Paramythiotou E | | 0，，04： | 1 |
| 11 | Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens显示文摘 | Garyphallia Poulakou Flora V. Kontopidou Elisabeth Paramythiotou Maria Kompoti Maria Katsiari Efstratios Mainas Chara Nicolaou Dimitrios Yphantis Anastasia Antoniadou Eleftheria Trikka-Graphakos Zoi Roussou Phyllis Clouva Nina Maguina Kyriaki Kanellakopou | 2009 | Journal of Infection2009，，4： | 1 |
| 12 | Co- listin for KlebsieUa pneumoniae-associated sepsis显示文摘 | Karabinis A Paramythiotou E Mylona-Petropoulou D | 2004 | Clin Infect Dis2004，38，1： | 1 |
| 13 | Posterior reversible encephalopathy syndrome in an intensive care unit patient receiving tacrolimus显示文摘 | Frantzeskaki F Paramythiotou E Papathanasiou M | 2008 | Acta Anaesthesiol Scand2008，52，8： | 1 |
| 14 | Invasivefungal infections in the ICU:how to approach,how to treat显示文摘 | Paramythiotou E Frantzeskaki F Flevari A | 2014 | Molecules2014，19，1： | 1 |
| 15 | Invasive fungal infections in the ICU:how to approach,how to treat显示文摘 | Paramythiotou E Frantzeskaki F2 Flevari A | 2014 | Molecules2014，19，1： | 1 |
| 16 | Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens显示文摘 | Poulakou G Kontopidou FV Paramythiotou E | 2009 | J Infect2009，58，4： | 1 |
| 17 | Acquisition of multidrug - resistant Pseudomonas aerugincsa in patients in intensive Care units: role of antibiotics with antipsandomonal activity显示文摘 | PARAMYTHIOTOU E LUCET JC TIMSIT J F | 2004 | Clin Infect Dis2004，38，： | 1 |
| 18 | Acquisition of muhiresistant pseudomona aeruginosa in patients in intensive care units; role of antibiotics with antipsiudomonal activity显示文摘 | Paramythiotou E Lucet JC Timsit JF | 2004 | Clin Infect Dis2004，38，5： | 1 |
| 19 | Acquisition of multidrug-resistant Pseudomonas aeruginosa in pa- tients in intensive care units:role of antibiotics with antip- seudomonal activity显示文摘 | Paramythiotou E Lucet JC Timsit JF | 2004 | Clin Infect Dis2004，38，5： | 1 |
| 20 | Acquisition of multidrug-resistant Pseudomonas aeruginosain patients in intensive care units:role of antibiotics with antipseudomonal activity显示文摘 | Paramythiotou E Lucet JC Timsit JF | | 0，，02： | 1 |
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