4篇
您的检索式：作者名="Elisabeth Paramythiotou"
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| 1 | Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients显示文摘The incidence of gram-negative multidrug-resistant(MDR) bacterial pathogens is increasing in hospitals and particularly in the intensive care unit(ICU) setting. The clinical consequences of infections caused by MDR pathogens remain controversial. The purpose of this review is to summarize the available data concerning the impact of these infections on mortality in ICU patients. Twenty-four studies, conducted exclusively in ICU patients, were identified through Pub Med search over the years 2000-2015. Bloodstream infection was the only infection examined in eight studies, respiratory infections in four and variable infections in others. Comparative data on the appropriateness of empirical antibiotic treatment were provided by only seven studies. In ten studies the presence of antimicrobial resistance was not associated with increased mortality; on the contrary, in other studies a significant impact of antibiotic resistance on mortality was found, though, sometimes, mediated by inappropriate antimicrobial treatment. Therefore, a direct association between infections due to gram-negative MDR bacteria and mortality in ICU patients cannot be confirmed. Sample size, presence of multiple confounders and other methodological issues may influence the results. These data support the need for further studies to elucidate the real impact of infections caused by resistant bacteria in ICU patients. | Elisabeth Paramythiotou Christina Routsi | 2016 | World Journal of Critical Care Medicine2016，5，2： | 3 |
| 2 | Tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens显示文摘 | Garyphallia Poulakou Flora V. Kontopidou Elisabeth Paramythiotou Maria Kompoti Maria Katsiari Efstratios Mainas Chara Nicolaou Dimitrios Yphantis Anastasia Antoniadou Eleftheria Trikka-Graphakos Zoi Roussou Phyllis Clouva Nina Maguina Kyriaki Kanellakopou | 2009 | Journal of Infection2009，，4： | 1 |
| 3 | Invasive fungal infections in the ICU:how to approach,how to treat显示文摘 | Elisabeth Paramythiotou Frantzeska Frantzeskaki Aikaterini Flevari | 2014 | Molecules2014，19，1： | 1 |
| 4 | Severe Candida infections in critically ill patients with COVID-19显示文摘The frequency of co-infections with bacterial or fungal pathogens has constantly increased among critically ill patients with coronavirus disease 2019(COVID-19)during the pandemic.Candidemia was the most frequently reported invasive fungal co-infection.The onset of candidemia in COVID-19 patients was often delayed compared to non-COVID-19 patients.Additionally,Candida invasive infections in COVID-19 patients were more often linked to invasive procedures(e.g.,invasive mechanical ventilation or renal replacement therapy)during the intensive care stay and the severity of illness rather than more“classic”risk factors present in patients without COVID-19(e.g.,underlying diseases and prior hospitalization).Moreover,apart from the increased incidence of candidemia during the pandemic,a worrying rise in fluconazole-resistant strains was reported,including a rise in the multidrug-resistant Candida auris.Regarding outcomes,the development of invasive Candida co-infection had a negative impact,increasing morbidity and mortality compared to non-co-infected COVID-19 patients.In this narrative review,we present and critically discuss information on the diagnosis and management of invasive fungal infections caused by Candida spp.in critically ill COVID-19 patients. | Despoina Koulenti Marios Karvouniaris Elisabeth Paramythiotou Nikolaos Koliakos Nikolaos Markou Paschalis Paranos Joseph Meletiadis Stijn Blot | 2023 | Journal of Intensive Medicine2023，3，4： | 0 |
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