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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | lpxA/lpxC/lpxD基因突变致鲍曼不动杆菌耐多黏菌素作用机制显示文摘目的探讨细胞膜脂质A生物合成基因lpxA/lpxC/lpxD突变导致鲍曼不动杆菌临床株对多黏菌素耐药的机制。方法用透射电子显微镜(TEM)观察细菌细胞壁、细胞内外膜的变化;用气相色谱(GC)法定量测定脂肪酸含量观察脂多糖(LPS)的变化。此外,用分子生物学方法确定菌株编码细胞膜脂质生物合成的lpxA/lpxC/lpxD基因突变。结果 TEM显示多黏菌素耐药鲍曼不动杆菌细胞外膜和内膜完整性降低,失去细胞壁膜间隙的均一性。GC结果表明短碳链饱和脂肪酸和脂肪酸醇有下降趋势,且几乎失去了所有的未知脂肪酸,但长碳链饱和、不饱和脂肪酸和脂肪酸醇的量都增加了。参与细胞膜脂质生物合成的lpx、lpxC和lpxD基因发现有缺失、点突变和插入等改变。结论多黏菌素耐药鲍曼不动杆菌存在lpxA/lpxC/lpxD基因突变及细胞内外膜改变。 | 张文利 Joan-Miquel Balada-Llasat Vijay Pancholi Bhowmik Aurosree Bhavani Gopalakrishnan Preeti Pancholi | 2015 | 中国感染与化疗杂志2015，15，6： | 2 |
| 3 | 强化与标准降压治疗对脑卒中亚型的影响显示文摘在收缩压干预试验(systolic blood pressure intervention trial, SPRINT)中,各治疗组的脑卒中发生比例差异无统计学意义,但脑卒中亚型的病因不同,可能对强化降压治疗的反应不同。SPRINT纳入患者(n=9 361)随机分为目标收缩压<120 mm Hg(1 mm Hg=0.133 kPa)的强化治疗与目标收缩压<140 mm Hg的标准治疗组。 | Wright CB Auchus AP Lerner A Ambrosius WT Ay H Bates JT Chen J Meschia JF Pancholi S Papademetriou V Rastogi A Sweeney M Willard JJ Yee J Oparil S 赵狄(摘译) 郑武洪(审校) | 2021 | 中华高血压杂志2021，29，3： | 2 |
| 4 | Multifunctional α-enolase: its role in disease显示文摘 | Pancholi V | 2001 | Cell Mol Life Sci2001，58，7： | 1 |
| 5 | Multifunctional a-enolase: its role in diseases 显示文摘 | Pancholi V | 2001 | CMLS2001，58，7： | 1 |
| 6 | Multifunctional c-enolase: its role in diseases 显示文摘 | Pancholi V | 2001 | Cell Mol Life Sci2001，58，7： | 1 |
| 7 | Technology Business Incubators in China and India: A Comparative Analysis显示文摘 | Tang Mingfeng Baskaran Angathevar Pancholi Jatin Lu Yong | 2013 | Journal of Global Information Technology Management2013，，2： | 1 |
| 8 | The effects of growth factors and conditioned media on the proliferation of human corneal epithelial cells and keratocytes显示文摘 | Sunil Pancholi Andrew Tullo Asud Khaliq David Foreman Mike Boulton | 1998 | Graefe’s Archive for Clinical and Experimental Ophthalmology1998，，1： | 1 |
| 9 | A major surface protein on group A streptococci is a glyceraldehyde-3-phosphate-dehydrogenase with multiple binding activity显示文摘 | Pancholi V Fischetti VA | 1992 | Exp Med1992，，176： | 1 |
| 10 | Design and rationale of the TOTAL trial: A randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST elevation myocardial infarction undergoing primary PCI显示文摘 | Sanjit S. Jolly John Cairns Salim Yusuf Brandi Meeks Olga Shestakovska Lehana Thabane Kari Niemel? Philippe Gabriel Steg Olivier F. Bertrand Sunil V. Rao Alvaro Avezum Warrren J. Cantor Samir B. Pancholy Raul Moreno Anthony Gershlick Ravinay Bhindi Robert | 2013 | American Heart Journal2013，，： | 1 |
| 11 | Multifunctional α-enolase: its role in diseases 显示文摘 | Pancholi V | 2001 | Cell Mol Life Sci2001，58，7： | 1 |
| 12 | Multifunctional a--enolase:its role in disease显示文摘 | Pancholi V | 2001 | Cell Mol Life Sci2001，58，： | 1 |
| 13 | Characterization and biological properties of a new staphylococcal exotoxin显示文摘 | Ren K Bannan JD Pancholi V | 1994 | J Exp Med1994，180，5： | 1 |
| 14 | Transradial approach for coronary angiography and interventions, results of the first international transradial practice survey显示文摘 | Bertrand Of Rao SV Pancholy S | 2010 | JACC Cardiovasc Interv2010，11，10： | 1 |
| 15 | Multifunctional alpha-enolase: its role in diseases 显示文摘 | Pancholi V | 2001 | Cell Mol Life Sci2001，58，7： | 1 |
| 16 | Alpha-enolase, a novel strong plasmin (ogen) binding protein on the surface of pathogenic streptococci 显示文摘 | Pancholi V Fischetti VA | 1998 | J Biol Chem1998，273，14： | 1 |
| 17 | DNA prime/canarypox boost-based immunotherapy of chronic hepatitis B virus infection in a chimpanzee显示文摘 | Pancholi P Lee DH Liu Q | 2001 | Hepatology2001，33，2： | 1 |
| 18 | A Period Study-Term Performance Pressure: Case of the British Biotech-nology Industry 显示文摘 | Angathevar Baskaran Jatin Pancholi and Firoozeh Ghaffari | 2006 | The Business Review2006，，5： | 1 |
| 19 | Effect of duration of hemostatic compression on radial artery occlusion after transradial access 显示文摘 | Pancholy SB Patel TM | 2012 | Catheter Cardiovasc Interv2012，79，1： | 1 |
| 20 | Carbohydrases in soil as affected by successional stages of revegetation显示文摘 | Pancholy S K Rice E L | 1973 | Soil Science Society of America Proceedings1973，37，： | 1 |
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