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| 1 | 黔中岩溶山区表土层中~7Be的分布特征及其侵蚀示踪研究显示文摘岩溶山区表土侵蚀是一突出环境问题,为认识其侵蚀特征,用宇宙线散落核素^7Be进行示踪分析。^7Be比活度随土层深度呈对数下降趋势,渗透深度深度约2-5mm,且秋季大于春季,在表土界层春季表观比活度大于秋季,土层中^7Be的累计值在土粒堆积区大于侵蚀区。 | 白占国 万国江 王长生 万曦 黄荣贵 P.H.Santschi M. Baskaran | 1997 | 自然科学进展(国家重点实验室通讯)1997，7，1： | 25 |
| 2 | Clinical and experimental research in antituberculosis drug-induced hepatotoxicity:a review显示文摘Drug-induced liver injury is the common adverse effect seen in patients receiving antituberculosis drugs(ATDs). There are several risk factors associated with the development of hepatotoxicity in such patients. Though there have been appreciable efforts taken by carrying out studies investigating the efficacy of several natural and synthetic compounds in minimising this effect, the only choice available for clinicians is withdrawal of drugs. This review would give a precise idea of ATD-induced hepatotoxicity,its underlying mechanisms and alternative therapies for the same. | Udhaya Lavinya Baskaran Evan Prince Sabina | 2017 | Journal of Integrative Medicine2017，15，1： | 20 |
| 3 | Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats显示文摘Objective:To assess the effect of quercetin(flavonoid) against lindane induced alterations in lipid profile of wistar rats.Methods:Rats were administered orally with lindane(100 mg/kg body weight) and quercetin(10 mg/kg body weight) for 30 days.After the end of treatment period lipid profile was estimated in serum and tissue.Results:Elevated levels of serum cholesterol, triglycerides,low density lipoprotein(LDL),very Low Density Lipoprotein(VLDL) and tissue triglycerides,cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.Conclusions:Our study suggests that quercetin has hypolipidemic effect and offers protection against lindane induced toxicity in liver by restoring the altered levels of lipids.The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane. | Viswanadha Vijaya Padma Gurusamy Lalitha Nichokon Puthanveedu Shirony Rathinasamy Baskaran | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 9 |
| 4 | Role of essential oils in food safety: Antimicrobial and antioxidant applications显示文摘Essential oils(EOs)are more complex and comprise a number of volatile and natural bioactive compounds,which often used in food industries as the best alternatives.This review focuses on the impact of EOs and the roles of their major components in food manufacturing as natural preservatives with the related mechanisms of action.In addition,the major bioactive molecules of different types of EOs and their pharmacological activities such as antioxidant,antifungal and antimicrobial effects on crop protection were also discussed.The major compounds of EOs represent potential antioxidant,antimicrobial and antifungal activities through various mechanisms.Different types of EOs such as tea tree oil,lemon oil,clove oil,cinnamon oil and thyme oil from various traditional plants,have significantly showed better antimicrobial and antioxidant activities,and also effectively increased the shelf lives of the cereal products and increased the quality of food safety.The major groups of EOs such as terpenes and aromatic volatile compounds,play a key role in food safety without affecting the quality.Due to their various activities including antioxidant and antimicrobial activities,EOs could be used as alternative preservatives to increase the shelf lives of cereals and crops. | Sundaresan Bhavaniramya Selvaraju Vishnupriya Mohammad Saleh Al-Aboody Rajendran Vijayakumar Dharmar Baskaran | 2019 | Grain & Oil Science and Technology2019，2，2： | 8 |
| 5 | An overview on recent in vivo biological application of cerium oxide nanoparticles显示文摘Cerium oxide nanoparticles(CNPs)possess a great potential as therapeutic agents due to their ability to self-regenerate by reversibly switching between two valences+3 and+4.This article reviews recent articles dealing with in vivo studies of CNPs towards Alzheimer’s disease,obesity,liver inflammation,cancer,sepsis,amyotrophic lateral sclerosis,acute kidney injury,radiation-induced tissue damage,hepatic ischemia reperfusion injury,retinal diseases and constipation.In vivo anti-cancer studies revealed the effectiveness of CNPs to reduce tumor growth and angiogenesis in melanoma,ovarian,breast and retinoblastoma cancer cell-induced mice,with their conjugation with folic acid,doxorubicin,CPM,or CXC receptor-4 antagonist ligand eliciting higher efficiency.After conjugation with triphenylphosphonium or magnetite nanoparticles,CNPs were shown to combat Alzheimer’s disease by reducing amyloid-β,glial fibrillary acidic protein,inflammatory and oxidative stress markers in mice.By improving muscle function and longevity,the citrate/EDTA-stabilized CNPs could ameliorate amyotrophic lateral sclerosis.Also,they could effectively reduce obesity in mice by scavenging ROS and reducing adipogenesis,triglyceride synthesis,GAPDH enzyme activity,leptin and insulin levels.In CCl4-induced rats,stress signaling pathways due to inflammatory cytokines,liver enzymes,oxidative and endoplasmic reticulum messengers could be attenuated by CNPs.Commercial CNPs showed protective effects on rats with hepatic ischemia reperfusion and peritonitis-induced hepatic/cardiac injuries by decreasing oxidative stress and hepatic/cardiac inflammation.The same CNPs could improve kidney function by diminishing renal superoxide,hyperglycemia and tubular damage in peritonitis-induced acute kidney injury in rats.Radiation-induced lung and testicular tissue damage could be alleviated in mice,with the former showing improvement in pulmonary distress and bronchoconstriction and the latter exhibiting restoration in spermatogenesis rate and spermatid/spermatocyte number.Through enhancement of gastrointestinal motility,the CNPs could alleviate constipation in both young and old rats.They could also protect rat from light-induced retinal damage by slowing down neurodegenerative process and microglial activation. | Baskaran Stephen Inbaraj Bing-Huei Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 6 |
| 6 | Au–Pd单原子合金(SAA)催化剂的催化机理和成键分析:CO氧化反应显示文摘单原子催化剂(SACs)在催化科学领域引起了人们的广泛关注,包括被称为单原子合金(SAAs)的包含金属-金属键合的双金属催化剂.本文通过量子化学计算方法研究了Au–Pd单原子合金模型Au37Pd1上CO氧化反应的催化机理和成键分析,确定了CO@Au–Pd,O2@Au–Pd和CO/O2@Au–Pd等吸附构型的几何结构以及吸附物与底物间的结合能.Pd原子位于核芯位置的核-壳结构被证实为Au–Pd单原子合金的最稳定构型,该结构的稳定性来源于Pd原子向Au原子的电荷转移.根据结合能和化学成键分析,CO和O2分子均优先吸附在配位数低且位于顶点位置的Pd原子上.本文报道了一种新的CO和O2共吸附结构,其中CO和O2分别在两个相邻Au–Pd键上以垂直和平行桥联方式吸附,该Au–Pd单原子合金的CO氧化反应具有低能垒且遵循Langmuir-Hinshewood(L-H)机理.本文探讨了单原子合金催化剂中单原子在催化反应中的重要作用,可以为设计具有优异催化活性的新型单原子合金催化剂提供依据. | Sambath Baskaran 许聪俏 王阳刚 Ig nacio LGarzon 李隽 | 2020 | Science China Materials2020，63，6： | 5 |
| 7 | 磷钨酸负载的非贵金属单原子催化剂:乙烯环氧化的理论研究显示文摘基于第一性原理,本文系统研究了过渡金属单原子(铁,钴,镍,钌,铑,钯,锇,铱,铂)负载在磷钨酸(PTA)催化剂上的几何和电子结构,并进一步研究了乙烯环氧化在铁单原子催化剂上的可能反应机理.我们发现PTA最可能结合过渡金属单原子的位置是四配位中空位.乙烯环氧化催化活性的理论计算表明,非贵金属Fe1-PTA具有可观的吸附能,这是引发此催化循环的关键物理量.我们进一步进行了铁单原子和PTA结合的成键分析,发现电荷从铁单原子转移到PTA团簇,并且强烈的Fe–O共价金属-载体相互作用(CMSI)是其高稳定性的基础.在催化剂Fe1-PTA上可能的乙烯环氧化催化机理共包括三步:1)氧气分子通过电荷转移吸附在Fe1-PTA上;2)第一个乙烯分子攻击吸附在Fe1-PTA上的氧气分子,随后形成C2H4O;3)表面吸附的氧原子和第二个乙烯分子生成C2H4O,完成催化循环.本研究发现,Fe1-PTA对于乙烯环氧化主要通过Eley-Rideal机理进行.本工作为发展高效多相非贵金属单原子乙烯环氧化催化剂提供了理论依据. | Shamraiz Hussain Talib 于小虎 于琦 Sambath Baskaran 李隽 | 2020 | Science China Materials2020，63，6： | 5 |
| 8 | Ivabradine in the treatment of systolic heart failure- A systematic review and meta-analysis显示文摘AIM To perform a systematic-review and meta-analysis to compare outcomes of ivabradine combined with betablocker to beta-blocker alone in heart failure with reduced ejection fraction(HFr EF).METHODS We searched PubM ed, Cochrane, EMBASE, CINAHL and Web of Science for trials comparing ivabradine + betablocker to beta-blocker alone in HFr EF. We performed a systematic-review and meta-analysis of published literature. Primary end-point was combined end point of cardiac death and hospitalization for heart failure.RESULTS Six studies with 17671 patients were included. Mean follow-up was 8.7 ± 7.9 mo. Combined end-point of heart failure readmission and cardiovascular death was better in ivabradine + beta-blocker group compared to beta-blocker alone(RR: 0.93, 95%CI: 0.79-1.09, P = 0.354). Mean difference(MD) in heart rate was higher in the ivabradine + beta-blocker group(MD: 6.14, 95%CI: 3.80-8.48, P < 0.001). There was no difference in all cause mortality(RR: 0.98, 95%CI: 0.89-1.07, P = 0.609), cardiovascular mortality(RR: 0.99, 95%CI: 0.86-1.15, P = 0.908) or heart failure hospitalization(RR: 0.87, 95%CI: 0.68-1.11, P = 0.271). CONCLUSION From the available clinical trials, ivabradine + betablocker resulted in a significantly greater reduction in HRcoupled with improvement in combined end-point of heart failure readmission and cardiovascular death but with no improvement in all cause or cardiovascular mortality. Given the limited evidence, further randomized controlled trials are essential before widespread clinical application of ivabradine + beta-blocker is advocated for HFrEF. | Mahesh Anantha Narayanan Yogesh NV Reddy Janani Baskaran Abhishek Deshmukh David G Benditt Ganesh Raveendran | 2017 | World Journal of Cardiology2017，9，2： | 5 |
| 9 | Pupil constriction can alter the accuracy of dark room provocative test显示文摘背景主要角度闭合绿内障( PACG )是在东方Asia.Dark房间挑衅性的测试( DRPT )的视觉病态的一个主要原因被用来决定狭窄的角度哪个有风险开发角度 closure.However ,因为, DRPT 的精确性可能被改变那在从黑暗房间出现以后,角度的配置被裂缝灯的光影响,这研究的同位格地关上的角度 reopens.The 目的是在不同轻 conditi | WANG Bing-song WANG Ning-li Nathan Congdon LEI Kun Baskaran Mani | 2009 | Chinese Medical Journal2009，，21： | 4 |
| 10 | Rare earth(Gd,La) co-doped ZnO nanoflowers for direct sunlight driven photocatalytic activity显示文摘In this work Gd/La@ZnO nanoflower photocatalyst was successfully synthesized by a co-precipitation method and applied for rhodamine B(Rh B) and tetracycline(TCN) degradation under direct sunlight irradiation.The doping of rare earth elements extends the optical absorption wavelength of ZnO from UV region(390 nm) to visible-light region(401 nm).In addition,the co-doped ZnO nanoflower exhibits a lower charge recombination efficiency which was confirmed by photoluminescence emission analysis.Moreover,the co-doped ZnO nanoflower exhibits the maximum degradation efficiency of 91% for Rh B and 74% for TCN under sunlight irradiation.The calculated synergistic index of co-doped ZnO is higher than that of the pure ZnO.Reactive radicals’ production was confirmed by terephthalic acid(TA) and nitro-blue tetrazolium(NBT) tests.The holes and hydroxyl(·OH) radicals play the major role in degradation reaction and it was confirmed by scavenger’s test.Moreover,the recycling test confirms the stability of the photocatalyst. | Baskaran Palanivel Romulo R.Macadangdang Jr Md Shahadat Hossain Fahad A.Alharthi Mohanraj Kumar Jih-Hsing Chang Sreedevi Gedi | 2023 | Journal of Rare Earths2023，41，1： | 3 |
| 11 | Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors显示文摘Human pluripotent stem cells(hPSC)hold considerable promise as a source of adult cells for treatment of diseases ranging from diabetes to liver failure.Some of the challenges that limit the clinical/translational impact of hPSCs are high cost and difficulty in scaling-up of existing differentiation protocols.In this paper,we sought to address these challenges through the development of bioactive microcapsules.A co-axial flow focusing microfluidic device was used to encapsulate hPSCs in microcapsules comprised of an aqueous core and a hydrogel shell.Importantly,the shell contained heparin moieties for growth factor(GF)binding and release.The aqueous core enabled rapid aggregation of hPSCs into 3D spheroids while the bioactive hydrogel shell was used to load inductive cues driving pluripotency maintenance and endodermal differentiation.Specifically,we demonstrated that one-time,1 h long loading of pluripotency signals,fibroblast growth factor(FGF)-2 and transforming growth factor(TGF)-β1,into bioactive microcapsules was sufficient to induce and maintain pluripotency of hPSCs over the course of 5 days at levels similar to or better than a standard protocol with soluble GFs.Furthermore,stem cell-carrying microcapsules that previously contained pluripotency signals could be reloaded with an endodermal cue,Nodal,resulting in higher levels of endodermal markers compared to stem cells differentiated in a standard protocol.Overall,bioactive heparin-containing core-shell microcapsules decreased GF usage five-fold while improving stem cell phenotype and are well suited for 3D cultivation of hPSCs. | Kihak Gwon Hye Jin Hong Alan M.Gonzalez-Suarez Michael Q.Slama Daheui Choi Jinkee Hong Harihara Baskaran Gulnaz Stybayeva Quinn P.Peterson Alexander Revzin | 2022 | Bioactive Materials2022，7，9： | 3 |
| 12 | Cellular metabolic energy modulation by tangeretin in 7,12-dimethylbenz(a) anthracene-induced breast cancer显示文摘Breast cancer is the leading cause of death among women worldwide.Chemoprevention and chemotherapy play beneficial roles in reducing the incidence and mortality of cancer.Epidemiological and experimental studies showed that naturally-occurring antioxidants present in the diet may act as anticancer agents.Identifying the abnormalities of cellular energy metabolism facilitates early detection and management of breast cancer.The present study evaluated the effect of tangeretin on cellular metabolic energy fluxes in 7,12-dimethylbenz(a)anthracene(DMBA)-induced proliferative breast cancer.The results showed that the activities of glycolytic enzymes significantly increased in mammary tissues of DMBA-induced breast cancer bearing rats.The gluconeogenic tricarboxylic acid(TCA) cycle and respiratory chain enzyme activities significantly decreased in breast cancer-bearing rats.In addition,proliferating cell nuclear antigen(PCNA) was highly expressed in breast cancer tissues.However,the activities of glycolytic enzymes were significantly normalized in the tangeretin pre- and post-treated rats and the TCA cycle and respiratory chain enzyme activities were significantly increased in tangeretin treated rats.Furthermore,tangeretin down-regulated PCNA expression on breast cancerbearing rats.Our study demonstrates that tangeretin specifically regulates cellular metabolic energy fluxes in DMBA-induced breast cancer-bearing rats. | Kuppusamy Periyasamy Venkatachalam Sivabalan Kuppusamy Baskaran Kannayiram Kasthuri Dhanapal Sakthisekaran | 2016 | The Journal of Biomedical Research2016，30，2： | 3 |
| 13 | Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats显示文摘The present study aimed to evaluate the effects of chrysoeriol from Cardiospermum halicacabum in streptozotocin induced Wistar rats.Thirty rats were categorized as control,diabetic control supplemented with 0,20 mg/kg chrysoeriol and 600μg/kg BW of glibenclamide for 45-day trial period.Our results indicated that the inclusion of chrysoeriol(20 mg/kg)showed a significant reduction in plasma glucose,hemoglobin and glycosylated hemoglobin level with a rising of plasma insulin sensitivity.Further,downregulated enzymes including glucose 6-phosphatase,fructose 1,6-bisphosphatase,and glycogen phosphorylase as well upregulated enzymes such as hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,and hepatic glycogen content.There was a diminish action found in liver glycogen synthase of tested rat with a rise in gamma-glutamyl transpeptidase,towards normal levels upon treatment with chrysoeriol.The histopathological study confirmed that renewal of the beta cells of pancreatic of chrysoeriol and glibenclamide treated rats.In addition,the molecular docking of chrysoeriol against glycolytic enzymes including hexokinase,glucose-6-phosphate dehydrogenase,pyruvate kinase,using Argus software shows chrysoeriol had greatest ligand binding energy as equivalent to glibenclamide,as a standard drug.Thus,chrysoeriol found to be non-toxic with potential regulation on glycemic control and upregulation of the carbohydrate metabolic enzymes. | Baskaran Krishnan Abirami Ramu Ganesan Ravindran Balasubramani Dinh Duc Nguyen Soon Woong Chang Shaoyun Wang Jianbo Xiao Balamuralikrishnan Balasubramanian | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 14 | Proton Conducting Polymer Electrolytes and Its Applications显示文摘 | S. Selvasekarapandian G. Hirankumar R. Baskaran M.S. Bhuvaneswari | 2005 | 复旦学报(自然科学版)2005，44，5： | 3 |
| 15 | Follow-up of Primary Angle Closure Suspects After Laser Peripheral Iridotomy Using Ultrasound Biomicroscopy and A-Scan Biometry for a Period of 2 Years显示文摘 | Krishna Kumar Ramani Baskaran Mani Ronnie J. George Vijaya Lingam | 2009 | Journal of Glaucoma2009，，7： | 2 |
| 16 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 17 | 非贵金属单原子催化剂Co_(1)/MXene(Mo_(2)CS_(2))的CO氧化反应机理研究显示文摘MXene是一类由前过渡态金属碳化物、氮化物或碳氮化物构成的新型二维材料.我们利用量子化学方法研究了单原子Co在新型二维MXene材料Mo2CS2上的吸附构型、稳定性和催化性质.研究发现Co原子可以稳定锚定在MXene材料的表面,形成的单原子催化剂适合于催化低温CO氧化.计算表明,吸附的CO和O2分子与Co_(1)/Mo_(2)CS_(2)催化剂表面之间的电荷转移在活化这些小分子时起着重要作用.我们研究了Co1/Mo2CS2催化氧化CO的三种机理:Eley-Rideal(ER),Langmuir-Hinshelwood(LH)和Termolecular Eley-Rideal(TER),发现在低温下这三种反应机理都是可行的.其中在Co_(1)/Mo_(2)CS_(2)催化剂上TER机理具有最高的催化活性,计算的决速步能垒分别为0.67(TER),0.78(LH)和0.88 eV(ER).我们的研究结果表明,利用二维材料MXene发展和设计经济的、非贵金属单原子催化剂具有重要应用前景. | Shamraiz Hussain Talib Sambath Baskaran 于小虎 于琦 Beenish Bashir Shabbir Mahammad Sajjad Hussain 陈学年 李隽 | 2021 | Science China Materials2021，64，3： | 2 |
| 18 | Prevalence of Plateau Iris in Primary Angle Closure Suspects显示文摘 | Rajesh S. Kumar Mani Baskaran Paul T.K. Chew David S. Friedman Swati Handa Raghavan Lavanya Lisandro M. Sakata Hon-Tym Wong Tin Aung | 2008 | Ophthalmology2008，，3： | 2 |
| 19 | 蕨类植物治疗人类疾病的应用概况(英文)显示文摘蕨类植物全世界约48科250属12000种,目前只有少数蕨类植物的生物学活性得到了研究,这些研究已经证明蕨类植物的药用价值及其在植物科学领域的重要性。本文旨在总结关于蕨类植物的主要化学成分及药理活性,特别是其抗氧化活性、抗肿瘤活性、抗糖尿病活性、抗病毒活性、抗炎活性、抗菌活性、抗老年痴呆症和脑疾病活性等,可用于替代医学的各种人类疾病治疗。然而,它们的最佳剂量和治疗策略仍需要进一步研究。 | Xavier-ravi BASKARAN Antony-varuvel GEO VIGILA Shou-zhou ZHANG Shi-xiu FENG Wen-bo LIAO | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，2： | 2 |
| 20 | Study on vital static properties of fine blanking of GFRP composites with that of conventional drillingl显示文摘 | BASKARAN G GOWRI S KRISHNAMURTHY R | 2010 | Int J Adv Manuf Techno2010，，50： | 1 |
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