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| 1 | Burden of care in caregivers of patients with alcohol use disorder and schizophrenia and its association with anxiety, depression and quality of life显示文摘Background Caregivers play a pivotal role in providing care for mentally ill patients.Increase in caregiver burden can make them vulnerable to mental illness themselves.Aims We assessed the severity of burden of care and its association with depression,anxiety and quality of life among caregivers of patients with alcohol use disorder(AUD)and schizophrenia.Methods This was an observational,cross-sectional,single-centred study of 50 consecutive caregivers of patients with AUD and schizophrenia.Participants were recruited from the psychiatry outpatient department of a tertiary care hospital between January and June 2017.The caregivers were further assessed by demographic details,Hospital Anxiety Depression Scale for assessment of depression and anxiety,Zarit Burden Interview for assessment of caregiver burden and WHO Quality Of Life-BREF for assessment of quality of life.Statistical data were analysed using GraphPad InStat V.3.06(California).Multiple linear regression analysis was applied to identify the predictors of caregiver burden.Results Burden of care experienced by caregivers of patients with AUD is as high as that of caregivers of patients with schizophrenia(U=1142.5,p=0.46).Caregivers experiencing high burden of care are likely to have symptoms of anxiety(U=22,p<0.001),depression(U=32,p<0.001)and poor quality of life(U=84.5,p<0.001).Female caregivers are likely to experience higher burden of care(U=819.5,p=0.006).For caregivers of patients with schizophrenia,anxiety,environmental health,socioeconomic status and patients,occupation can predict burden of care,while for caregivers of patients with AUD,depression and environmental health can predict burden of care.Conclusion Our study suggests that caregivers of patients with AUD experience burden of care as high as that of caregivers of patients with schizophrenia.Caregivers with high burden of care are more likely to have depression,anxiety and poor quality of life.Trial registration number CTRI/2017/03/008224. | Sneha Vadher Rishi Desai Bharat Pancha Ashok Vala Imran Jahangirali Ratnani Mihir P Rupani Kinjal Vasava | 2020 | General Psychiatry2020，33，4： | 7 |
| 2 | MPEG coding for variable bit rate video transmission显示文摘 | PANCHA P ZARKI M E1 | 1994 | IEEE Communications Magazine1994，32，5： | 1 |
| 3 | MPEG coding for variable bit rate video transmission显示文摘 | El Zarki M | 1994 | IEEE Communication Magazine1994，，： | 1 |
| 4 | Closure of mill whitewater systems reduces water use, conserves energy显示文摘 | Pancha P B | 1992 | Pulp&Paper1992，66，3： | 1 |
| 5 | Closure of mill whitewater systems reduces water use,conserves energy显示文摘 | PANCHA PAKESAN B | 1992 | Pulp & Paper1992，66，3： | 1 |
| 6 | PPAR gamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose显示文摘 | Pancha Pakesan U Sumual S Pollock CA | 2005 | Am J Physiol2005，289，5： | 1 |
| 7 | Closure of mill whitewater systems reduces water use, conserves energy 显示文摘 | Pancha Pakesan B | 1992 | Pulp & Paper1992，66，3： | 1 |
| 8 | Building smaller sized surrogate models of complex bipartite networks based on degree distributions显示文摘 | LE Q PANCHA J H | 2012 | Systems and Humans2012，42，5： | 1 |
| 9 | MPEG coding for variable bit rate video transmission显示文摘 | Pancha P Zarki M El | 1994 | IEEE Communications Magazine1994，32，5： | 1 |
| 10 | Comparative thermal performance of shell and tube heat exchanger with continuous helical baffle using 显示文摘 | SHINDE P S PANCHA M H | 2012 | International Journal of Engineering Research and Applications2012，2，4： | 1 |
| 11 | Closure of mill whitewater systems reduces water use,conserves energy显示文摘 | Pancha Pakesan B | 1992 | Pulp & Paper1992，66，3： | 1 |
| 12 | Fatty acids as biomarkers of microalgae显示文摘 | Abhishek Sahu Imran Pancha Deepti Jain Chetan Paliwal Tonmoy Ghosh Shailesh Patidar Sourish Bhattacharya Sandhya Mishra | 2013 | Phytochemistry2013，，： | 1 |
| 13 | Fatty acids as biomarkers of microalgae显示文摘 | SAHU A PANCHA I JAIN D | 2013 | Phytochemistry2013，89，： | 1 |
| 14 | MPEG coding for variable bit rate video transmission显示文摘 | PANCHA P EL ZARKI M | 1994 | IEEE Communications Magazine1994，32，5： | 1 |
| 15 | Evaluation of the diuretic effects of crude stem bark extraction of Zanthoxylum heitzii(Rutaceae) in Wistar rats显示文摘OBJECTIVE: Zanthoxylum heitzii is a medicinal plant widely used in central Africa for the treatment of many diseases, especially cardiovascular diseases and hypertension. The diuretic effects of crude stem bark extraction were determined and its safety in rats was evaluated.METHODS: The diuretic effects of crude stem bark extraction of Z. heitzii were investigated in Wistar rats(250 g ± 10 g) of both sexes. The crude stem bark extraction of Z. heitzii at the doses of 225, 300 and 375 mg/kg was administered to rats at 5 m L/kg body weight. Urine volume was determined 1, 2, 3, 4, 5, 6 and 24 h after administration of the extract. Kinetics of electrolyte elimination in response to a single oral administration dose of acute treatment was measured. The experiments were performed under the same conditions with two synthetic pharmacological diur etics considered as reference(furosemide and hydrochlorothiazide). Urinary and plasma concentrations of sodium and potassium ions were determined using fl ame photometry. Concentrations of creatinine, urea, glucose, albumin and electrolytes in the plasma and urine samples were evaluated using a two-way digital bidirectional spectrophotometer. The osmolarity of plasma and urine samples was measured by cytometry using an osmometer. Aldosterone was measured by radioimmunoassay.RESULTS: The plant extract accelerated the elimination of overloaded fl uid and increased urine volume and the excretion of Na+, K+ and Cl- 24 h after administration(P<0.05). The increase in elimination of Na+, K+, and Cl- induced by the extract caused alkalinization of the urine, and showed a strong inhibitory effect on carbonic anhydrase and saluretic. These effects were mainly observed at the dose of 375 mg/kg. At the maximum diuretic response, urinary osmolarity decreased significantly(P < 0.05) when compared to controls. The stability of aldosterone level, the absence of correlation with the plasma levels of Na+, and increased clearance of free water in the animals treated with extract indicated that increased diuresis and natriuresis were tubular in origin. No significant(P > 0.05) changes were observed in the body temperature of the animals.CONCLUSION: The significant increase in urine volume 24 h after treatment followed a doseresponse pattern. The excretion of Na+, K+ and Cl- caused a decrease in urine osmolarity. The stability of aldosterone, the absence of correlation with the plasma levels of sodium, and increased clearance of free water in animals treated with aqueous extract suggest that increased diuresis and moderate natriuresis elevation were of tubular origin. | Fidèle Ntchapda Maguirgue Kakesse Michel Archange Tagne Fokam Olivier Mbouemboue Pancha Djedouboum Abakar Théophile Dimo | 2015 | Journal of Integrative Medicine2015，13，5： | 0 |
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