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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation显示文摘血浆膜(下午) 水泡是发生的动态充满肌动朊的房间伸出,例如在胞质分裂期间,似变形虫的房间活动性和房间附件。用对 21 个肌动朊成核因素的一幅指向的 siRNA 屏幕,我们在房间粘附期间在下午 blebbing 识别一篇小说和人的透明 formin DIAPH3 的必要角色。DIAPH3 的抑制禁止了 blebbing 支持快速的房间传播包含 β 1-integrin。DIAPH3 的多重 isoforms 在 mRNA 和 isoforms, 3 和 7 是然而没导致充满肌动朊的伸出的形成的最大、很丰富的 isoforms 的蛋白质水平上被检测。更确切地说,下午 blebbing 明确地包含了低丰富 isoform 7 由透明自动调整的领域的删除引起了 filopodia 的形成的 isoform 的 1 DIAPH3 和激活。Dimerization 和肌动朊集会活动为由 DIAPH3 isoforms 的特定的房间伸出的正式就职是必要的 1 和 7。我们的数据建议包括 GTPase 有约束力的域的 N 终端区域象它在水泡和 filopodia 之间的伸出活动一样决定了 formin 的 subcellular 本地化。我们建议由 DIAPH3 的 isoform 选择的肌动朊汇编施加特定并且调整的差别在房间粘附和活动性期间工作。 | Jana Stastna Xiaoyu Pan Haicui Wang Alina Kollmannsperger Stefan Kutscheidt Volker Lohmann Robert Grosse Oliver T Fackler | 2012 | Cell Research2012，22，4： | 6 |
| 3 | 地面堆载作用下黏弹性地层盾构施工诱发土体响应时域解显示文摘目前针对软土地层盾构施工诱发周围土体变形影响的研究一般是基于瞬时开挖工况,较少考虑黏弹性土体的流变特性,也较少考虑地表堆载给盾构隧道施工所带来的影响。从地基黏弹性角度出发,引入隧道洞周的椭圆化收敛变形模式,采用复变函数理论并运用Laplace变换技术,提出了地表堆载作用下盾构隧道开挖引起的周围土体位移和应力的时域解。依托相关工程监测数据与简化时域解对比,得到了较好的一致性。研究结果表明:所得出的时域解能较好地反映地表堆载作用下盾构隧道开挖对周围土体位移场的影响,以及地层变形随时间的发展趋势。在地表堆载影响下,随着时间推移,开挖引起的地层变形不断增加,沉降速率则呈现出逐渐衰弱直至为零规律,而堆载突变导致其地表沉降值尤其沉降速率变化显著。研究成果对黏性地层密集堆载群范围内的隧道施工控制具有一定理论指导意义。 | 张治国 张洋彬 张成平 王志伟 PAN Y T | 2021 | 岩土工程学报2021，43，1： | 4 |
| 4 | Ganglioside patterns in neuroepithelial tumors of childhood显示文摘 | Pan X L Izumi T Yamada H | 2000 | Brain Dev2000，22，3： | 2 |
| 5 | 饲料中添加蛋白酶对肉鸡性能、养分利用率、肠道形态和胴体品质的影响显示文摘试验在饲喂玉米、高粱为主的肉鸡日粮中补充大豆,并添加蛋白酶,研究蛋白酶对肉鸡性能、养分消化率、肠道形态和胴体品质的影响。试验选取1日龄AA肉仔鸡(43.8±1.31 g)256只,均为公鸡,随机分配到2×2试验设计方阵中,方阵包括正常组(玉米组和高粱组)和蛋白酶组(空白组和添加蛋白酶150 mg·kg^(-1)的试验组)。试验1~21 d为第一阶段,22~42 d为第二阶段。试验结果表明,第二阶段中,日粮中添加蛋白酶极显著提高肉鸡的平均日增重(ADG,P<0.01),在整个试验过程中显著提高(P<0.05)。在各个时期,正常组对肉鸡生产性能均无显著影响(P>0.05)。19~21 d时,添加蛋白酶可显著提高肉鸡的表观代谢能(AME),干物质(DM)、总能量(GE)和养分消化率(P<0.05)。此外,日粮以高粱为主时,AME、GE消化率有降低趋势(P=0.05),氮沉积率也有降低趋势(P=0.08)。40~42 d时,日粮中添加蛋白酶可显著提高AME,DM、GE和氮沉积率(P<0.05)。21 d时,日粮中添加蛋白酶极显著增加肠绒毛高度、肠绒毛与隐窝深度比值,极显著降低十二指肠、空肠、回肠的隐窝深度(P<0.01)。42 d时,日粮中添加蛋白酶显著增加空肠肠绒毛高度、绒毛高度与隐窝深度比值,显著降低隐窝深度(P<0.05)。日粮中添加蛋白酶显著增加胸肌重、24 h p H,显著降低胸肌的滴水损失(P<0.05)。试验结果表明,饲养阶段日粮中添加复合蛋白酶可提高肉鸡ADG;在第一阶段可改善AME、DM、GE和氮沉积率和肠道形态。补充蛋白酶可提高出栏重、胸肌重和24 h pH,降低胸肌的滴水损失。低单宁高粱日粮与玉米日粮相比,对肉鸡性能的影响相近。 | Xu X Wang H L Pan L Ma X K Tian Q Y Xu Y T Long S F Zhang Z H Piao X S | 2017 | 饲料博览2017，0，1： | 2 |
| 6 | 降雨诱发滑坡对非连续接口输气管道受力影响分析显示文摘既有成果还较少涉及降雨条件下滑坡对管道结构时域变形的解析分析,且针对滑坡–管道相互作用的理论研究仅限于连续管道,未考虑管道接口和管内气压的影响。首先,基于Green-Ampt模型得出的边坡降雨入渗规律,以边坡湿润锋作为滑坡滑动面,采用不平衡推力法计算出滑坡推力;其次,将滑坡推力施加到非连续接口管道上,基于Pasternak地基模型并考虑输气压力作用,求解出降雨条件下滑坡区域输气管道任意截面的内力和位移。在此基础上,结合工程实测值与本文解析解进行对比验证,获得了较好的一致性。最后,针对降雨强度参数进行了敏感性分析和输气管道安全评价。结果表明:随着降雨历时发展,降雨强度的增大引起非连续管道的变形值和变形速率显著增大,管道最大位移增长速率开始迅速下降的时间点逐渐提前;管道最大当量应力随着连续降雨历时增长而增大,直至超出输气管道安评范围。 | 张治国 方蕾 张成平 Y T Pan 吴钟腾 | 2022 | 岩土工程学报2022，44，2： | 2 |
| 7 | Vapor pressure measurements of dimethyl ether from 233 to 399 K 显示文摘 | Wu J T Liu Z G Pan J | 2004 | Journal of Chemical and Engineering Data2004，49，1： | 2 |
| 8 | Restrictions to HIV-1 replication in resting CD4+T lymphocytes显示文摘CD4 + T 淋巴细胞代表人的免疫不全病毒(HIV ) 的主要目标房间人口。处于一个激活的状态,居住在淋巴的器官的 CD4 + T 细胞是在感染的个人的进行中的 HIV-1 复制的一座主要水库。相反,放松 CD4 + T 房间对生产 HIV-1 感染高度抵抗,还大规模在疾病前进期间被弄空并且代表为在 vivo 的病毒的一座实质的潜伏的水库。在放松 CD4 + T 房间阻止 HIV-1 的复制的障碍包括外皮的肌动朊的僵硬的层并且,在 HIV-1 入口以后早,限制到来的病毒的 RNA 染色体的反向的抄写的块。定义这些限制的分子的底在 HIV 研究仍然是中央待研究的问题之一。最近的进展解开了 HIV-1 由绕过入口的机制堵住并且建立了主人房间限制因素 SAMHD1, deoxynucleoside triphosphate triphosphohydrolase,到在放松 CD4 + T 房间的 HIV-1 反向的抄写的细胞的限制的一个中央决定因素。这评论总结我们分子的水流和和放松 CD4 + T 淋巴细胞的 HIV-1 的滑稽得多的相互作用的 pathophysiological 理解。 | Xiaoyu Pan Hanna-Mari Baldauf Oliver T Keppler Oliver T Fackler | 2013 | Cell Research2013，23，7： | 2 |
| 9 | LDL-C levels,lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA显示文摘Background and purpose Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack(TIA).This study aimed to investigate the association between baseline low-density lipoprotein cholesterol(LDL-C)level,lipid-lowering treatment and short-term risk of new stroke in patients with a minor ischaemic stroke or TIA.Methods We derived data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Patients with a minor stroke or TIA were categorised by LDL-C level at baseline(<2.6 or≥2.6 mmol/L(100 mg/dL))and with or without lipid-lowering treatment after symptom onset.The primary outcome was a new ischaemic stroke at 3 months.The association of baseline LDL-C level,lowering treatment and outcomes were assessed.Results Among 3027 patients,2154(71.2%)patients had an initial LDL-C≥2.6 mmol/L,of which 1267(41.9%)received lipid-lowering treatment.Elevated LDL-C level was associated with a higher risk of new ischaemic stroke at 3 months in patients without lipid-lowering treatment(adj.HR=1.35,95%CI:1.19 to 1.53),but not in those with lipid-lowering treatment(adj.HR=0.99,95%CI:0.82 to 1.19)(p for interaction=0.007).Patients with LDL-C≥2.6 mmol/L had a numerically higher risk of ischaemic stroke(11.8%vs 8.0%,adj.HR=1.37,95%CI:0.96 to 1.96)in those without lipid-lowering treatment.For patients with LDL-C≥2.6 mmol/L,lipid-lowering treatment was associated with reduced risk of ischaemic stroke at 3 months(7.9%vs 11.8%;adj.HR=0.54,95%CI:0.39 to 0.75).Conclusions Elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischaemic stroke among patients presenting with minor ischaemic stroke or TIA.There was potential benefit of lipid-lowering treatment in minor stroke or TIA patients with LDL-C≥2.6 mmol/L.Trial registration number NCT00979589. | Yuesong Pan Runqi Wangqin Hao Li Aoming Jin Jiejie Li Jinxi Lin Xia Meng Ying Xian Daniel T Laskowitz Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 10 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 11 | Three-dimensional analysis of single pile response to lateral soil movements显示文摘 | Pan J L Goh A T C Wong K S | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，，26： | 1 |
| 12 | Improvements in sintered density and dimensional stability of powder injection-molded 316L compacts by adjusting the alloying compositions显示文摘 | Shu G J Hwang K S Pan Y T | 2006 | Acta Materialia2006，54，2006： | 1 |
| 13 | Statins are associated with a reduced incidence of perioperative mortality after coronary artery bypass graft surgery显示文摘 | Pan W Pintar T Anton J | 2004 | Circulation2004，110，111： | 1 |
| 14 | Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes显示文摘 | Pan T T Feng Z N Lee S W | 2006 | J Mol Cell Cardiol2006，40，1： | 1 |
| 15 | Chemokine receptor-8(CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion显示文摘 | Haque NS Fallon J T Pan JJ | 2004 | Blood2004，103，6： | 1 |
| 16 | An improved hysteresis current controller for reducing switching frequency显示文摘 | C T Pan T Y Chang | 1994 | IEEE Trans on Power Electronics1994，，： | 1 |
| 17 | Decreased NURR1 gene expression in patients with Parkinson's disease显示文摘 | Le W Pan T Huang M | 2008 | J Neurol Sci2008，273，12： | 1 |
| 18 | Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways显示文摘 | Hu Y Chen X Pan T T | 2008 | Pflugers Arch2008，455，4： | 1 |
| 19 | Effect of green tea polyphenols on dopamine uptake and on MPP ^+ -induced dopamine neuron injury显示文摘 | Pan T H Fei J Zhou X B | 2003 | Life Sci2003，72，： | 1 |
| 20 | Resistance to ammonia stress of Penaeus monodon Fabricius Juvenile fed diets supplemented with astaxanthin 显示文摘 | PAN C H CHIEN Y H HUNTER B T | 2003 | J Exp Marine Biol Ecol2003，297，1： | 1 |
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