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| 1 | 长期食用含糖和人工甜味剂的饮料与美国成年人死亡风险的关系显示文摘摄入含糖饮料(sugar-sweetened beverages,SSB)或含人工甜味剂饮料(artificially sweetened beverages,ASB)是否与死亡风险相关,这关乎公共卫生利益。研究者分析了卫生专业人员随访研究(1986-2014年)中男性37 716人和护士健康研究(1980-2014年)中女性80 647人(基线无慢性病)的SSB和ASB的消费与总死亡率和病因特异性死亡率之间的关系。应用Cox比例风险回归估计风险比和95%CI。结果显示,在随访3415564人年期间,研究者记录了36436例死亡,其中心血管病死亡7896例,癌症死亡12380例。 | 刘青(译) 叶鹏(摘、审校) Malik VS Li Y Pan A De Koning L Schernhammer E Willett WC Hu FB | 2019 | 中华高血压杂志2019，27，5： | 9 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 4 | Development of biomedical publications on ametropia research in PubMed from 1845 to 2010:a bibliometric analysis显示文摘We have carried out a bibliometric analysis on the development of ametropia literature to determine its growth rule and tendency,and to provide the basis for the problems related to ametropia research.Literatures that contained the descriptors of ametropia in title or paper published before Nov.10,2010 in PubMed databases(www.ncbi.nlm.nih.gov/Pubmed) were selected.As bibliometric indicators of ametropia,biomedical journals referring to ophthalmology by ISSN were calculated.The principal bibliometric indicators:Price's and Bradford's laws were applied on the increase or dispersion of scientific literature,the participation index of languages and the journals.By means of manual coding,literatures were classified according to documents study and statistical analysis.The literatures cited in ametropia,astigmatism,myopia and hypermetropia had accumulated to 26475,which consists of Review(n =1560),Randomized Controlled Trial(n =776),Practice Guideline(n =10),Meta-Analysis(n =23),Letter(n =1222),Editorial(n =328),Clinical Trial(n =1726) and Others(n =20830);and Humans(n =23073),Animals(n=1434) and Others(n =1968).1136 literatures were included in PubMed Central,22384 in MEDLINE and 2955 in others.The ametropia literatures rose every 5 years which of the ametropia-year cumulated amount of the literatures had three periods:before 1900,slowly increasing from 1901 to 1950,rapidly rising from 1951 to 2010(increased approximate exponentiation exponent).Sixty kinds of languages were listed in PubMed databases,of which English was dominant for aborting to ametropia research documents before 2010(77.32%,20471/26475).The document language of top eight accounted for 95.58%(English,German,French,Japanese,Russian,Italian,Spanish,Chinese),and others for 4.42%(1171/26475).The SCI database includes 48 ophthalmologic journals and the impact factor of 39 journals is ≥ 1 on Thomson-Reuters in 2010.Of 48 ophthalmologic journals,there were 14785 documents(55.85%) of ametropia,astigmatism,myopia,and hypermetropia.Others were without exception.The bibliometric analysis results show that ametropia literature are increased progressively,approximate exponentiation exponent during 1951-2010.In addition,ametropia research has become more popular since nearly half century. | Chang-Tai Xu, Bo-Rong Pan | 2011 | International Journal of Ophthalmology(English edition)2011，4，1： | 7 |
| 5 | Investigation of recombinant Schistosoma japonicum paramyosin fragments for immunogenicity and vaccine efficacy in mice显示文摘 | Zhang DM Pan WQ Qian L Duke M Shen LH McManus DP | 2006 | 第二军医大学学报2006，27，6： | 6 |
| 6 | Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions显示文摘 | Jian Gu Xuhao Ni Xiongxiong Pan Hao Lu Yunjie Lu Jie Zhao Song Guo Zheng Keli L Hippen Xuehao Wang Ling Lu | 2017 | Cellular & Molecular Immunology2017，14，6： | 6 |
| 7 | Predictive factors of recurrent angina after acute coronary syndrome: the global registry acute coronary events from China (Sino-GRACE)显示文摘背景:有急性冠的症候群(交流) 的许多病人在住院期间开发周期性的咽峡炎(RA ) 。非使随机化的、未来的学习是与交流在 unselected 病人调查 RA 的预兆的因素的这的目的在中国在住院期间在全球登记注册了尖锐冠的事件(优雅) 。方法:在 2001 年 3 月和 2004 年 10 月之间,注册了是有交流的 1433 个病人,包括圣片断举起心肌的梗塞(662, 46.2%) ,非圣片断举起心肌的梗塞(239, 16.7%) 并且不稳定的咽峡炎(532, 37.1%) 。人口统计的分发,病历和临床的数据被收集由逻辑回归调查 RA 的预兆的因素。结果:(19.2%) 在住院 275 期间,病人们包括不稳定的咽峡炎(53.2%) 与 RA 被记录,非圣片断举起心肌的梗塞(27.5%) ,圣片断举起心肌的梗塞(19.3%) 。dyslipidemia 的 comorbidity,优先的咽峡炎,在 6 个月以内的经皮的冠的干预(一种总线标准) 在有 RA 的病人是更普通的, P <
0.05。在有 RA 的病人,有尖锐肺水肿的病人的一个显著地更高的比例被观察, 23 (8.4%) 对 43 (3.7%) , P = 0.001。尖锐肾衰竭在 8 是在场的(2.9%) 有 RA 的病人对 19 (1.6%) 没有 RA 的病人, P = 0.165。出血性的事件在 6 是在场的(2.2%)有 RA 的病人对 8 (0.7%)没有 RA ,在 12 个病人(4.3%)的室的 tachycardia/ventricular 纤维性颤动事件对 22 个病人(1.9%)的病人,在 69 个病人(25.0%)的充血心力衰竭对 94 个病人(8.1%),在 28 个病人(10.1%)对 15 个病人(1.3%)的心肌的重新梗塞, P <
0.05 分别地。有 RA 的病人的一个更低的比例经历了在里面医院一种总线标准, 687 (59.3%) 对 114 (41.5%) , P = 0.000。有 RA 的病人的一个更高的比例收到了肝磷脂, 260 (94.5%) 对 1035 (89.4%) , P = 0.006;并且 beta-blockers 176 (64.0%) 对 864 (74.5%) , P = 0.000。 Multivarible 回归分析证明 RA 与优先的咽峡炎被联系(或 2.086 ,95% CI 1.466 - 2.967 ),在里面医院一种总线标准(或 0.579 ,95% CI 0.431 - 0.778 ),在里面医院充血心力衰竭(或 2.410 ,95% CI 1.634 - 3.555 ),心肌的重新梗塞(或 7.695 ,95% CI 3.701 - 15.999 ),贝它块(或 0.626 ,95% CI 0.458 - 0.855 ),并且肝磷脂(或 3.411 ,95% CI 1.604 - 7.382 )。结论:在里面医院充血心力衰竭,心肌的重新梗塞,优先的咽峡炎历史和肝磷脂的使用是 RA 的更强壮的独立预言者;beta-blockers 和一种总线标准也是为 RA 的重要预兆的因素。 | ZHAO Fu-hai CHEN Yun-dai SONG Xian-tao PAN Wei-qi JIN Ze-ning YUAN Fei LI Yong-bin Ren Fang Lü Shu-zheng | 2008 | Chinese Medical Journal2008，，1： | 6 |
| 8 | Regenerative Role of Soil Seed Banks of Different Successional Stages in A Saline-alkaline Grassland in Northeast China显示文摘Soil seed banks can act as a potential seed source for natural revegetation and restoration. However, in a saline-alkaline grassland, it remains unclear how the stages of vegetation succession affect the characteristics of soil seed banks and the potential of soil seed banks of different successional stages for vegetation restoration. In this study, seasonal changes of the soil seed bank, and seed production and dispersal dynamics along degradation successional gradients were investigated in a saline-alkaline grassland in Northeast China, where the dominant grass during the 1960 s, Leymus chinensis was replaced with the secondary successional order of Puccinellia chinampoensis, Chloris virgata, and Suaeda salsa, together with bare patches. It was found that the soil seed bank composition varied according to the changing vegetation and had the highest species richness(7–16) in the climax successional stage, but had a low S?rensen similarity(0.22–0.37) with the aboveground vegetation. There was a high seed density of the soil seed bank(21 062–62 166/m2 in August and December) and also high S?rensen similarity index values(0.47–0.60) in the secondary successional stages of P. chinampoensis, C. virgata, and S. salsa. In bare patches, there were many seeds in the soil seed bank and some seedlings also appeared in the aboveground vegetation, indicating the existence of a persistent soil seed bank. Seed density and species richness differed substantially among the different successional stages, which was related to the reproductive characteristics of the standing plants in vegetation communities. Due to the lack of propagules of perennial species, especially the climax species of L. chinensis, in the soil, the successful restoration of the degraded saline-alkaline grassland was not possible. The study proved that in a degraded saline-alkaline grassland dominated by biennial or annual species, the soil seed bank was important for the revegetation of the current dominant plants, but not for the restoration of the original target species. Therefore, it is necessary to induce seeds or other propagules of the target perennial species. | MA Hongyuan LI Jingpeng YANG Fan Lü Xiaotao PAN Yuepeng LIANG Zhengwei | 2018 | Chinese Geographical Science2018，28，4： | 5 |
| 9 | Revisiting the Concentration Observations and Source Apportionment of Atmospheric Ammonia显示文摘While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East China.As the high nitrate abundances are strongly linked with ammonia,reducing ammonia emissions is becoming increasingly important to improve the air quality of China.Although satellite data provide evidence of substantial increases in atmospheric ammonia concentrations over major agricultural regions,long-term surface observation of ammonia concentrations are sparse.In addition,there is still no consensus on whether agricultural or non-agricultural emissions dominate the urban ammonia budget.Identifying the ammonia source by nitrogen isotope helps in designing a mitigation strategy for policymakers,but existing methods have not been well validated.Revisiting the concentration measurements and identifying source apportionment of atmospheric ammonia is thus an essential step towards reducing ammonia emissions. | Yuepeng PAN Mengna GU Yuexin HE Dianming WU Chunyan LIU Linlin SONG Shili TIAN Xuemei LÜ Yang SUN Tao SONG Wendell WWALTERS Xuejun LIU Nicholas AMARTIN Qianqian ZHANG Yunting FANG Valerio FERRACCI Yuesi WANG | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 10 | Preparation of Al matrix nanocomposites by diluting the composite granules containing nano-SiCp under ultrasonic vibaration显示文摘In this work, an efficient process by diluting the nano-SiCp/Al composite granules in the molten matrix under ultrasonic vibration(UV) was developed to prepare metal matrix nano-composites(MMNCs).Millimeter-sized composite granules with high content of SiC particle(8 wt%) were specially fabricated by dry high-energy ball milling(HBM) without process control agent, and then remelted and diluted in molten Al alloy under UV. The MMNCs melt was finally squeeze cast under a squeeze pressure of 200 MPa, Microstructure of the composite granules during dry HBM was investigated, and the effect of UV on microstructure and mechanical properties of the MMNCs was discussed. The results indicate that nano-SiC particles are uniformly distributed in the nano-SiCp/Al composite granules, which are covered by vestures of pure Al. During diluting, nano-SiC particles released from the composite granules are quickly dispersed in the molten matrix by UV within 4 min. Microstructure of MMNCs is significantly refined under UV and squeeze casting, eutectic Si phase modified to fine islands with an average length of 1.4 μm. Tensile strength of the squeeze cast MMNCs with 1 wt% of nano-SiC particles is 269 MPa, which is improved by 25% compared with the A356 alloy matrix. | Shulin Lü Pan Xiao Du Yuan Kun Hu Shusen Wu | 2018 | Journal of Materials Science & Technology2018，34，9： | 3 |
| 11 | Evaluation of 5 versus 10 granulocyteaphaeresis sessions in steroid-dependent ulcerative colitis: A pilot, prospective, multicenter, randomized study显示文摘瞄准:与活跃类固醇依赖者 ulcerative 在病人与 10 个 granulocyteaphaeresis 会议相比评估 5 的功效。方法:在这名飞行员,未来,多集中使随机化的试用,有中等活跃的类固醇的 20 个病人 -- 依赖 ulcerative 被使随机化到 5 或 10 个 granulocyteaphaeresis 会议。主要目的是在 wk 的临床的宽恕 17。第二等的措施包括了内视镜的宽恕和类固醇消费。结果:九个病人被使随机化到 5 个 granulocyteaphaeresis 会议(组 1 ) 和 11 个病人到 10 个 granulocyteaphaeresis 会议(组 2 ) 。在 wk 17,在在组 2 的组 1 病人和 45.45% 的 37.5% 病人在临床的宽恕。临床的宽恕被内视镜的宽恕在所有情况中伴随。完成宽恕的百分之 86 个病人在 wk 是没有类固醇的 17。每日的类固醇要求在组 2 是显著地更低的。病人的 89% 在一年后续期间留在宽恕。一个严肃的不利事件不与学习治疗有关,被报导。结论:Granulocyteaphaeresis 为类固醇依赖者 ulcerative 的治疗安全、有效。在这张人口,增加 aphaeresis 会议的数字没与更高的宽恕率被联系,但是负担得起重要类固醇圆材效果。 | Elena Ricart Maria Esteve Montserrat Andreu Francesc Casellas David Monfort Miquel Sans Natalia Oudovenko Raúl Lafuente Julián Panés | 2007 | World Journal of Gastroenterology2007，13，15： | 3 |
| 12 | Ganglioside patterns in neuroepithelial tumors of childhood显示文摘 | Pan X L Izumi T Yamada H | 2000 | Brain Dev2000，22，3： | 2 |
| 13 | 饲料中添加蛋白酶对肉鸡性能、养分利用率、肠道形态和胴体品质的影响显示文摘试验在饲喂玉米、高粱为主的肉鸡日粮中补充大豆,并添加蛋白酶,研究蛋白酶对肉鸡性能、养分消化率、肠道形态和胴体品质的影响。试验选取1日龄AA肉仔鸡(43.8±1.31 g)256只,均为公鸡,随机分配到2×2试验设计方阵中,方阵包括正常组(玉米组和高粱组)和蛋白酶组(空白组和添加蛋白酶150 mg·kg^(-1)的试验组)。试验1~21 d为第一阶段,22~42 d为第二阶段。试验结果表明,第二阶段中,日粮中添加蛋白酶极显著提高肉鸡的平均日增重(ADG,P<0.01),在整个试验过程中显著提高(P<0.05)。在各个时期,正常组对肉鸡生产性能均无显著影响(P>0.05)。19~21 d时,添加蛋白酶可显著提高肉鸡的表观代谢能(AME),干物质(DM)、总能量(GE)和养分消化率(P<0.05)。此外,日粮以高粱为主时,AME、GE消化率有降低趋势(P=0.05),氮沉积率也有降低趋势(P=0.08)。40~42 d时,日粮中添加蛋白酶可显著提高AME,DM、GE和氮沉积率(P<0.05)。21 d时,日粮中添加蛋白酶极显著增加肠绒毛高度、肠绒毛与隐窝深度比值,极显著降低十二指肠、空肠、回肠的隐窝深度(P<0.01)。42 d时,日粮中添加蛋白酶显著增加空肠肠绒毛高度、绒毛高度与隐窝深度比值,显著降低隐窝深度(P<0.05)。日粮中添加蛋白酶显著增加胸肌重、24 h p H,显著降低胸肌的滴水损失(P<0.05)。试验结果表明,饲养阶段日粮中添加复合蛋白酶可提高肉鸡ADG;在第一阶段可改善AME、DM、GE和氮沉积率和肠道形态。补充蛋白酶可提高出栏重、胸肌重和24 h pH,降低胸肌的滴水损失。低单宁高粱日粮与玉米日粮相比,对肉鸡性能的影响相近。 | Xu X Wang H L Pan L Ma X K Tian Q Y Xu Y T Long S F Zhang Z H Piao X S | 2017 | 饲料博览2017，0，1： | 2 |
| 14 | Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells显示文摘 | Pan J Xia L McEver RP | 1998 | J Biol Chem1998，273，10： | 2 |
| 15 | A review on MBE-grown HgCdSe infrared materials on GaSb(211)B substrates显示文摘We review our recent efforts on developing HgCdSe infrared materials on Ga Sb substrates via molecular beam epitaxy(MBE) for fabricating next generation infrared detectors with features of lower production cost and larger focal plane array format size. In order to achieve high-quality HgCdSe epilayers, ZnTe buffer layers are grown before growing HgCdSe, and the study of misfit strain in ZnTe buffer layers shows that the thickness of ZnTe buffer layer needs to be below 300 nm in order to minimize the generation of misfit dislocations. The cut-off wavelength/alloy composition of HgCdSe materials can be varied in a wide range by varying the ratio of Se/Cd beam equivalent pressure during the HgCdSe growth.Growth temperature presents significant impact on the material quality of HgCdSe, and lower growth temperature leads to higher material quality for HgCdSe. Typically, long-wave infrared HgCdSe(x = 0.18, cut-off wavelength of 10.4 μm at 80 K) presents an electron mobility as high as 1.3×10~5cm^2·V^(-1)·s^(-1), a background electron concentration as low as 1.6×10^(16)cm^(-3), and a minority carrier lifetime as long as 2.2 μs. These values of electron mobility and minority carrier lifetime represent a significant improvement on previous studies of MBE-grown HgCdSe reported in the open literatures,and are comparable to those of counterpart HgCdTe materials grown on lattice-matched CdZnTe substrates. These results indicate that HgCdSe grown at the University of Western Australia, especially long-wave infrared can meet the basic material quality requirements for making high performance infrared detectors although further effort is required to control the background electron concentration to below 10^(15)cm^(-3). More importantly, even higher quality HgCdSe materials on GaSb are expected by further optimizing the growth conditions, using higher purity Se source material, and implementing postgrowth thermal annealing and defect/impurity gettering/filtering. Our results demonstrate the great potential of HgCdSe infrared materials grown on GaSb substrates for fabricating next generation infrared detectors with features of lower cost and larger array format size. | Z K Zhang W W Pan J L Liu W Lei | 2019 | Chinese Physics B2019，28，1： | 2 |
| 16 | Pharmacological evaluation of several major ingredients of Chinese herbal medicines in human hepatoma Hep3B cells 显示文摘 | Chou C C Pan S L Teng C M | 2003 | Eur J Pharm Sci2003，19，5： | 2 |
| 17 | Auxin Binding Protein 1 Reinforces Resistance to Sugarcane Mosaic Virus in Maize显示文摘 | Pengfei Leng Qing Ji Torben Asp Ursula K. Frei Christina R. Ingvardsen Yongzhong Xing Bruno Studer Margaret Redinbaugh Mark Jones Priyanka Gajjar Sisi Liu Fei Li Guangtang Pan Mingliang Xu Thomas Lǖbberstedt | 2017 | Molecular Plant2017，10，10： | 2 |
| 18 | Analysis on the impact of aerosol optical depth on surface solar radiation in the Shanghai megacity, China显示文摘 | Xu J. Li C. Shi H. He Q. Pan L | 2011 | Atmospheric Chemistry and Physics2011，，224： | 2 |
| 19 | Experimental and numerical study of the vortex filaments in the wake of an operational horizontal-axis wind turbine 显示文摘 | GRANT l PAN X | 2000 | Journal of Wind Engineering and Industrial Aerodynamics2000，85，2： | 1 |
| 20 | PCBs, PCNs and PBDEs in sedin2ents and mussels from Qingdso coastal sea in the frame of current circulations and influence of sewage sludge 显示文摘 | PAN J YANG Y L XU Q etal | 2007 | Chemosphere2007，66，： | 1 |
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