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| 1 | IRG1 induced by heme oxygenase- 1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production显示文摘 | Md Jamal Uddin Yeonsoo Joe Seul-Ki Kim Sun Oh Jeong Stefan W Ryter Hyun-Ock Pae Hun Taeg Chung | 2016 | Cellular & Molecular Immunology2016，13，2： | 10 |
| 2 | 1,2,3,4,6-penta-O-galloyl-β-D-glucose up-regulates heme oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular signal-regulated kinase-dependent manner in HepG2 cells显示文摘AIM: To examine the potency of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) as a hepatic heme oxygen-ase-1(HO-1) inducer and its regulation in HepG2 cells. METHODS: Expression of HO-1 and NF-E2-related factor 2 (Nrf2) and activation of mitogen-activated protein (MAP) kinases were analyzed by Western blot, immuno-fluorescence assay, and flow cytometry. Transfections of HO-1 gene, small interfering RNAs for HO-1 and Nrf2, and dominant-negative gene for MAP/extracellular signal-regulated kinase (ERK) were carried out to dissect the signaling pathways leading to HO-1 expression in HepG 2 cells. RESULTS: PGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide. Moreover, PGG induced Nrf2 nuclear translocation, which was found to be an upstream step of PGG-induced HO-1 expression, and ERK activation, of which pathway was involved in PGG-induced Nrf2 nuclear translocation, HO-1 expression and cytoprotection. CONCLUSION: PGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK-depen-dent manner, and HO-1 expression by PGG may serve as one of the important mechanisms for its hepatoprotective effects. | Hyun-Ock Pae Gi-Su Oh Sun-On Jeong Gil-Saeng Jeong Bok-Soo Lee Byung-Min Choi Ho-Sub Lee Hun-Taeg Chung | 2006 | World Journal of Gastroenterology2006，12，2： | 3 |
| 3 | Negative oncologic impact of poor postoperative pain control in left-sided pancreatic cancer显示文摘AIM To investigate the association between postoperative pain control and oncologic outcomes in resected pancreatic ductal adenocarcinoma(PDAC).METHODS From January 2009 to December 2014, 221 patients were diagnosed with PDAC and underwent resection with curative intent. Retrospective review of the patients was performed based on electronic medical records system. One patient without records of numerical rating scale(NRS) pain intensity scores was excluded and eight patients who underwent total pancreatectomy were also excluded. NRS scores during 7 postoperative days following resection of PDAC werereviewed along with clinicopathologic characteristics. Patients were stratified into a good pain control group and a poor pain control group according to the difference in average pain intensity between the early(POD 1, 2, 3) and late(POD 5, 7) postoperative periods. Cox-proportional hazards multivariate analysis was performed to determine association between postoperative pain control and oncologic outcomes.RESULTS A total of 212 patients were dichotomized into good pain control group(n = 162) and poor pain control group(n = 66). Median follow-up period was 17 mo. A negative impact of poor postoperative pain control on overall survival(OS) was observed in the group of patients receiving distal pancreatectomy(DP group; 42.0 mo vs 5.0 mo, P = 0.001). Poor postoperative pain control was also associated with poor disease-free survival(DFS) in the DP group(18.0 mo vs 8.0 mo, P = 0.001). Patients undergoing pancreaticoduodenectomy or pylorus-preserving pancreaticoduodenectomy(PD group) did not show associations between postoperative pain control and oncologic outcomes. Poor patients' perceived pain control was revealed as an independent risk factor of both DFS(HR = 4.157; 95%CI: 1.938-8.915; P < 0.001) and OS(HR = 4.741; 95%CI: 2.214-10.153; P < 0.001) in resected left-sided pancreatic cancer.CONCLUSION Adequate postoperative pain relief during the early postoperative period has important clinical implications for oncologic outcomes after resection of left-sided pancreatic cancer. | Eun-Ki Min Jae Uk Chong Ho Kyoung Hwang Sang Joon Pae Chang Moo Kang Woo Jung Lee | 2017 | World Journal of Gastroenterology2017，23，4： | 2 |
| 4 | Seasonal tourism spaces in Estonia: Case study with mobile positioning data显示文摘 | Rein Ahas Anto Aasa ülar Mark Taavi Pae Ain Kull | 2006 | Tourism Management2006，，3： | 2 |
| 5 | Power, satisfaction, and relationship commitment in Chinese store–tenant relationship and their impact on performance显示文摘 | B. Ramaseshan Leslie S.C. Yip Jae H. Pae | 2005 | Journal of Retailing2005，，1： | 2 |
| 6 | Effect of biofeedback accompanying occupational therapy and functional electrical stimulation in hemiplegic patients显示文摘 | Maria Inês Paes Louren??o Linamara Rizzo Battistella Christina May Moran de Brito Gracinda Rodrigues Tsukimoto Margarida Harumi Miyazaki | 2008 | International Journal of Rehabilitation Research2008，，1： | 2 |
| 7 | Molsidomine ameliorates experimental allergic encephalomyelitis in lewis rats显示文摘 | Kwak HJ Pae HO Oh GS | 2003 | Immunopharmacol Immunotoxicol2003，25，1： | 1 |
| 8 | Roles of heme oxygenase-1 incurcumin-induced growth inhibition in rat smooth muscle cells显示文摘 | Pae HO Jeong GS Jeong SO | 2007 | Exp Mol Med2007，39，3： | 1 |
| 9 | Orbital lymphangioma with non-contiguous cerebral arteriovenous malformation,manifesting with thrombocytopenia (Kasabach-Merritt syndrome) and intracerebral hemorrhage显示文摘 | Vachharajani A Paes B | 2002 | Acta Pediatr2002，91，1： | 1 |
| 10 | Effects of oral administration of Phellinus linteus on the production of Th1-and Th2-type cytokines in mice显示文摘 | Oh G S Lee M S Pae H O | 2006 | Immunopharmacology and immunotoxicology2006，28，2： | 1 |
| 11 | Differentiation - inducing effects of verticinone ,an isostemidal alkaloid isolated from the bulbs of Fritillar- ia ussuriensis, on human promyelocytic leukemia HL - 60 cells 显示文摘 | Pae HO Oh H Choi BM | 2002 | Biol Pharm Bull2002，25，11： | 1 |
| 12 | Acetylcholinesteraseactivity changes on visceral organs of VMH lesion-induced obeserats显示文摘 | Paes AM Camiatto SR Francisco FA | 2006 | Int J Neurosci2006，116，11： | 1 |
| 13 | Acute bacterial suppurative thyroiditis: a clinical review and expert opinion显示文摘 | Paes JE Burman KD Cohen J | 2010 | Thyroid2010，20，3： | 1 |
| 14 | Heme oxygenase-1 : its therapeutic roles in inflammatory diseases 显示文摘 | Pae H O Chung H T | 2009 | Immune Netw2009，9，1： | 1 |
| 15 | Exogenous nitric oxide inhibits experimental autoimmune uveoretinitis development in lewis rats by modulation of the Th1-dependent immune response显示文摘 | Kwak HJ Yang YS Pae HO | 2001 | Mol cells2001，12，2： | 1 |
| 16 | Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression 显示文摘 | Choi B M Pae H O Jeong Y R | 2005 | Biochem Biophys Res Commun2005，327，4： | 1 |
| 17 | Increase in crystallinity in poly(vinylidene fluoride) by electron beam radiatipon显示文摘 | PAE K D BHATEJA K K GILBERT J R | 1987 | Polym Sci Phys Ed1987，25，8： | 1 |
| 18 | DNA vaccines against dengue virus based on the nsl gene: the influence of different signal sequences on the protein expression and its correlation to the immune response elicited in mice显示文摘 | Costa S M Azevedo A S Paes M V | 2007 | Virology2007，358，： | 1 |
| 19 | Tryptase inhibition blocks airway inflammation in a mouse asthma model显示文摘 | Oh SW Pae CI Lee DK | 2002 | J Immunol2002，168，4： | 1 |
| 20 | Expression of the angiogenetic factors, vascular endothelial cell growth factor, acidic and basic libroblast growth factor, tumor growth factor beta-1,plate let- derived endothelial cell growth factor, placenta growth factor, and pleiotophin in human primary breast cancer and its relation to angiogenesis显示文摘 | RELF M LEJEUNE S SCOTT PAE | 1997 | Cancer Res1997，57，： | 1 |
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