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| 1 | Comparison of renal safety of tenofovir and entecavir in patients with chronic hepatitis B: Systematic review with meta-analysis显示文摘BACKGROUND Recently, the American Association for the Study of Liver Disease suggested no preference between tenofovir(TDF) and entecavir(ETV) regarding potential long-term risks of renal complications. Over the years, renal safety has become a critical concern in nucleos(t)ide analog-treated patients due to the long-term use of these drugs. However, existing studies do not show significant differences in renal dysfunction between these two drugs. Further, there is a paucity of studies comparing the long-term renal effects of TDF and ETV.AIM To investigate the effects of TDF and ETV on renal function, we performed systematic review and meta-analysis.METHODS Two investigators independently searched the Cochrane Library, MEDLINE, and Embase databases for randomized controlled trials and nonrandomized studies(NRSs) using the keywords 'CHB', 'Tenofovir', and 'Entecavir', and additional references were obtained from the bibliographies of relevant articles published through December 2017. The quality of each study was assessed using the Newcastle-Ottawa scale and the Grading of Recommendations Assessment,Development and Evaluation criteria. The primary outcome was the change in serum creatinine level in the TDF and ETV groups at baseline, 6 mo, 12 mo and24 mo.RESULTSNine NRSs comprising 2263 participants met the inclusion criteria. Changes in creatinine levels were higher in the TDF group than in the ETV group at 6 mo[mean difference(MD) = 0.03 mg/dL;95%CI: 0.02-0.04;I2 = 0%], 12 mo(MD =0.05 mg/dL;95%CI: 0.02-0.08;I2 = 78%), and 24 mo(MD = 0.07 mg/dL;95%CI:0.01-0.13;I2 = 93%). The change in estimated glomerular filtration rate(eGFR) was significantly higher in the TDF group than in the ETV group at 6 mo[standardized mean difference(SMD),-0.22;95%Cl:-0.36--0.08;I2 = 0%], 12 mo(SMD =-0.24;95%Cl:-0.43--0.05;I2 = 50%), and 24 mo(-0.35;95%Cl:-0.61--0.09;I2= 67%).CONCLUSION TDF statistically significantly increased serum creatinine levels and decreased the eGFR in 6-24 mo compared to ETV, with moderate to low quality of evidence.However, the differences are negligible. | Hyo-Young Lee Hyunwoo Oh Chan-Hyuk Park Yee-Hui Yeo Mindie H Nguyen Dae-Won Jun | 2019 | World Journal of Gastroenterology2019，25，23： | 6 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | 过瘤胃蛋氨酸、赖氨酸和组氨酸对泌乳奶牛生产性能的影响显示文摘试验旨在研究饲料中单独添加或综合添加过瘤胃(RP)蛋氨酸、赖氨酸和组氨酸及可代谢蛋白(MP)对泌乳后期奶牛生产性能的影响。试验选取72头荷斯坦奶牛,随机分为6组,试验期9周。奶牛随机分配到6个试验组中,2周作为1个变量周期:MPA组,根据美国国家科学研究委员会(2001)标准,在饲料中添加调节MP到243 g·d-1;MPD组,不添加MP,MP含量低于标准量54 g·d-1;MPDM组,在MPD组的基础上加入RP蛋氨酸;MPDL组,在MPD组的基础上加入RP赖氨酸;MPDH组,在MPD组的基础上加入组氨酸;MPDMLH组,在MPD组的基础上加入RP蛋氨酸、RP赖氨酸和RP组氨酸。试验结果表明,与MPA组对比,MPD组的干物质采食量(DMI)、产奶量、乳成分(乳脂肪、乳蛋白和乳糖)及能量校正的牛乳(ECM)、ECM饲料利用效率、牛奶和血浆中的N均降低。在MPD基础上补充RP赖氨酸可使乳蛋白率、血浆中葡萄糖浓度增加,且牛奶中N元素含量有增加的趋势;补充RP组氨酸可使DMI、牛奶浓缩蛋白增加,且乳脂肪、乳蛋白和ECM显著增加;补充3种RP氨基酸时,增加了乳蛋白率,使DMI和乳脂率有增加趋势,也提高了乳脂肪、乳蛋白含量和ECM及ECM饲料利用效率。与MPA相比,MPD组牛奶中N的含量有降低趋势,且血浆中必需氨基酸(除赖氨酸和蛋氨酸)浓度均降低。补充RP赖氨酸、RP蛋氨酸和RP组氨酸提高了血浆中蛋氨酸(除MPDM组)、赖氨酸和组氨酸浓度。饲喂MPD的奶牛血红蛋白浓度降低,血浆生长素含量高于MPA组。MPD组牛奶中总饱和脂肪酸浓度有高于MPA和MPDMLH组的趋势。MPD组的多元不饱和脂肪、牛奶中奇链与支链脂肪酸含量与MPA组相比,有降低趋势。试验结果表明,对于饲料中缺乏MP的奶牛,在饲料中添加组氨酸和添加3种RP氨基酸(赖氨酸、蛋氨酸和组氨酸)均有提高牛奶产量和牛奶组分含量的可能性。 | Giallongo F Harper M T Oh J Lopes J C Lapierre H Patton R A Parys C Shinzato I Hristov A N | 2016 | 饲料博览2016，0，7： | 4 |
| 4 | Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice显示文摘Epigenetic 基因规定畸形包括精神分裂症和消沉在各种各样的 neuropsychiatric 混乱,以及在心情和焦虑的规定被含有。另外, epigenetic 机制涉及精神病学的药的行动。当前的 anxiolytic 药有新药的重要缺点,和开发被保证。二蛋白质, G9a (也作为 EHMT2 或 KMT1C 知道) 并且 GLP (象 G9a 一样蛋白质,也作为 EHMT1 或 KMT1D 知道) ,它甲醇化物离氨酸 9 histone H3 (H3K9 ) ,能正在答应 anxiolytic 目标。G9a 的出生后的基因大美人减少焦虑相关的行为,与由过去常对待焦虑(amitriptyline, imipramine 和 paroxetine ) 的一些药的 G9a 层次的减小一致。相反地,在有 GLP haplodeficiency 的老鼠有增加的像焦虑的行为。我们寻求了决定是否 G9a/GLP, UNC0642 和 A-366 的二个药理学禁止者,将有类似的效果到基因 G9a/GLP 不足。当予成年老鼠以时,我们发现有任何一个化合物的 G9a/GLP 抑制减少了像焦虑的行为,与在大脑的减少的 H3K9 methylation 一起。相反,到这些的暴露从胚胎的白天加重(E9.5 ) 9.5 增加了像焦虑的行为直到出生并且减少在成人生活的社会相互作用,当 H3K9 methylation 在在成年老鼠的大脑的正常层次时。这些调查结果增强 G9a/GLP 在大脑开发的不同阶段在像焦虑的行为上有不同效果的基因证据,并且建议指向这条 histone methyltransferase 小径能为开发新 anxiolytic 药是有用的。这些数据也建议在 utero 的抗抑郁剂暴露能在成人生活有否定效果,并且这些效果的进一步的调查被保证。 | Dong-yao WANG Joel KOSOWAN James SAMSOM Laura LEUNG Kai-lai ZHANG Ying-xiang LI Yan XIONG Jian JIN Arturas PETRONIS Gabriel OH Albert H C WONG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 4 |
| 5 | 乳腺癌生殖性危险因素与乳腺组织成分的关系显示文摘绝大多数乳腺肿瘤是由乳腺上皮细胞引起的癌变,被认为起源于乳腺间质成分的乳腺肉瘤则较罕见。由钼靶测量的乳腺密度越大,即有越高比例乳腺纤维腺体组织(由上皮和间质组成)的女性,乳腺癌风险越高。与生育相关的生殖因素也被认为是乳腺癌的风险因素,如胎次、初产年龄及母乳喂养等。为研究与生育相关的生殖因素与乳腺腺体组织成分关系,研究人员采用美国护士健康研究队列中经活检证实的良性乳腺疾病(BBD)女性开展研究。获取所有研究对象活检标本,使用深度学习技术在全切片图像上测量每种组织类型(上皮、间质和脂肪)百分比。研究共纳入经活检证实的BBD无癌女性983例,活检年龄范围19~58岁,平均活检年龄42岁。所有样本中上皮组织、间质组织及脂肪组织的比例范围分别为0.5%~52.2%(平均9.1%)、23.6%~99.0%(平均72.4%)及0~71.3%(平均18.5%)。多因素调整的广义线性回归分析结果显示,与已生育女性相比,未生育女性良性乳腺活检标本中上皮组织(β=-0.26,95%CI:-0.41~-0.11)和脂肪组织(β=-0.34,95%CI:-0.54~-0.13)比例较少,而间质组织比例较多(β=0.04,95%CI:0.01~0.08),尤其在绝经前女性中,组织分布比例差异更明显。在已生育女性中,生育胎次与间质组织比例呈负相关(每个孩子β=-0.01,95%CI:-0.02~-0.00);与初产年龄<25岁相比,初产年龄25~29岁女性良性乳腺活检标本中上皮组织比例较高(β=0.12,95%CI:0.03~0.21)。与母乳喂养时间0~1个月相比,母乳喂养持续时间≥24个月与良性乳腺活检标本中降低的脂肪组织比例有关(β=-0.30,95%CI:-0.54~-0.06;P_(趋势性)=0.04)。绝经前女性中,生育胎次多和初产年龄晚与较高比例上皮组织和较低比例间质组织有关。该研究结果也提示了上皮-间质相互作用的重要性。 | 高鹰(编译) Yaghjyan L Austin-Datta RJ Oh H | 2022 | 中华健康管理学杂志2022，16，2： | 3 |
| 6 | 高性能粉末冶金连杆在V6发动机中的应用显示文摘今天,减轻连杆重量对满足现代内燃机的各项要求是至关重要的。为了降低产品成本、改善NVH特性和提高轴瓦的可靠性,现代汽车公司(HMC)已采用粉末冶金锻造连杆取代传统的热锻连杆。通过提高质量和降低成本的优化设计,开发了轻型连杆。值得注意的是,粉末冶金锻造连杆的质量比传统的热锻连杆的质量小17.7%,而且,连杆大头质量比传统型连杆大头的质量小22.5%。采用轻型连杆可减小曲轴系的质量,从而也减小了主要运动件的质量。由于减小了质量,轴瓦可靠性和NVH特性均可提高。HMC在一台新型V6发动机上进行了疲劳、刚度和装机耐久性等对比试验。 | Paek S Y Ryou H S Oh J S 沈永生 | 1999 | 国外内燃机1999，31，5： | 2 |
| 7 | Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana显示文摘 | OH S A PARK J H LEE G I PACK K H PARK S K NAM H G | 1997 | Plant Journal1997，12，3： | 1 |
| 8 | 显示文摘 | Lee T H Oh C S Lee C G | 2004 | Scripta Materialia2004，5，50： | 1 |
| 9 | Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells显示文摘 | Oh M Choi S Chung H | 1999 | Int J Oncol1999，14，5： | 1 |
| 10 | Mechanical Behavior of Carbon Steels in the Temperature Range of Mushy Zone显示文摘 | Seol D J Won Y M Oh K H | 2000 | ISIJ International2000，40，4： | 1 |
| 11 | A new class of SN2 reactions catalyzed by protic solvents: facile fluorination for isotopic labeling of diagnostic molecules 显示文摘 | Kim D W Ahn D S Oh Y H | 2006 | J Am Chem Soc2006，128，16： | 1 |
| 12 | Microstruetural characterization of Al2O3-Ni composites prepared by electroless deposition 显示文摘 | OH I H LEE J Y HAN J K | 2005 | Surf Coat Technol2005，192，： | 1 |
| 13 | Hydrogen-reduction behavior and microstructural characteristics of WO3-CuO powder mixtures with various milling time显示文摘 | Oh S T Jeon H | 2003 | Journal of Alloys and Compounds2003，，354： | 1 |
| 14 | Preparation and humidity sensing behaviors of nanocrystalline SnO2 /TiO2 bilayered films显示文摘 | Tai W P Oh J H | 2002 | Thin Solid Films2002，422，： | 1 |
| 15 | Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease显示文摘 | Okuda S Oh Y Tsuruda H Onoyama K Fujimi S Fujishima M | 1986 | Kidney Int1986，29，2： | 1 |
| 16 | Selection of a Streptococcus equi mutant and optimization of culture conditions for the production of high molecular weight hyaluronic acid显示文摘 | KIM J H YOO S J OH D K | 1996 | Enzyme Microb Tech1996，19，6： | 1 |
| 17 | Relationship be- tween psychological factors and quality of life in subtypes of gastroesophageal reflux disease显示文摘 | Oh J H Kim T S Choi M G | 2009 | Gut Liver2009，3，4： | 1 |
| 18 | Axiomatic design of machine control System显示文摘 | LEE K D SUH N P OH J H | 2001 | Annals of the CIRP2001，50，1： | 1 |
| 19 | Effects of oral administration of Phellinus linteus on the production of Th1-and Th2-type cytokines in mice显示文摘 | Oh G S Lee M S Pae H O | 2006 | Immunopharmacology and immunotoxicology2006，28，2： | 1 |
| 20 | Hsp110 protects heatdenatured proteins and confers cellular thermoresistance 显示文摘 | Oh H J Chen X Subjeck JR | 1997 | J Biol Chem1997，272，31： | 1 |
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