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| 1 | Negative oncologic impact of poor postoperative pain control in left-sided pancreatic cancer显示文摘AIM To investigate the association between postoperative pain control and oncologic outcomes in resected pancreatic ductal adenocarcinoma(PDAC).METHODS From January 2009 to December 2014, 221 patients were diagnosed with PDAC and underwent resection with curative intent. Retrospective review of the patients was performed based on electronic medical records system. One patient without records of numerical rating scale(NRS) pain intensity scores was excluded and eight patients who underwent total pancreatectomy were also excluded. NRS scores during 7 postoperative days following resection of PDAC werereviewed along with clinicopathologic characteristics. Patients were stratified into a good pain control group and a poor pain control group according to the difference in average pain intensity between the early(POD 1, 2, 3) and late(POD 5, 7) postoperative periods. Cox-proportional hazards multivariate analysis was performed to determine association between postoperative pain control and oncologic outcomes.RESULTS A total of 212 patients were dichotomized into good pain control group(n = 162) and poor pain control group(n = 66). Median follow-up period was 17 mo. A negative impact of poor postoperative pain control on overall survival(OS) was observed in the group of patients receiving distal pancreatectomy(DP group; 42.0 mo vs 5.0 mo, P = 0.001). Poor postoperative pain control was also associated with poor disease-free survival(DFS) in the DP group(18.0 mo vs 8.0 mo, P = 0.001). Patients undergoing pancreaticoduodenectomy or pylorus-preserving pancreaticoduodenectomy(PD group) did not show associations between postoperative pain control and oncologic outcomes. Poor patients' perceived pain control was revealed as an independent risk factor of both DFS(HR = 4.157; 95%CI: 1.938-8.915; P < 0.001) and OS(HR = 4.741; 95%CI: 2.214-10.153; P < 0.001) in resected left-sided pancreatic cancer.CONCLUSION Adequate postoperative pain relief during the early postoperative period has important clinical implications for oncologic outcomes after resection of left-sided pancreatic cancer. | Eun-Ki Min Jae Uk Chong Ho Kyoung Hwang Sang Joon Pae Chang Moo Kang Woo Jung Lee | 2017 | World Journal of Gastroenterology2017，23，4： | 2 |
| 2 | Molsidomine ameliorates experimental allergic encephalomyelitis in lewis rats显示文摘 | Kwak HJ Pae HO Oh GS | 2003 | Immunopharmacol Immunotoxicol2003，25，1： | 1 |
| 3 | Roles of heme oxygenase-1 incurcumin-induced growth inhibition in rat smooth muscle cells显示文摘 | Pae HO Jeong GS Jeong SO | 2007 | Exp Mol Med2007，39，3： | 1 |
| 4 | Differentiation - inducing effects of verticinone ,an isostemidal alkaloid isolated from the bulbs of Fritillar- ia ussuriensis, on human promyelocytic leukemia HL - 60 cells 显示文摘 | Pae HO Oh H Choi BM | 2002 | Biol Pharm Bull2002，25，11： | 1 |
| 5 | Exogenous nitric oxide inhibits experimental autoimmune uveoretinitis development in lewis rats by modulation of the Th1-dependent immune response显示文摘 | Kwak HJ Yang YS Pae HO | 2001 | Mol cells2001，12，2： | 1 |
| 6 | Critial role of heme oxgenase-1 in Foxp3-mediated immune suppression显示文摘 | Pae HO Jeong YR | 2005 | Biochem Biophys Res Commun2005，327，4： | 1 |
| 7 | Role of heme oxygenase-1 in vascular disease显示文摘 | CHUNG HT PAE HO CHA YN | 2008 | Curr Pharm Des2008，14，5： | 1 |
| 8 | Heme oxygenase-1 : its therapeutic roles in inflammatory diseases 显示文摘 | Pae HO Chung HT | 2009 | Immune Network2009，9，1： | 1 |
| 9 | Nitric oxide as a bioregulator of apeptosis显示文摘 | Chung HT Pae HO Choi BM | 2001 | Biochem Biophys Bes Commun2001，282，5： | 1 |
| 10 | 3-Hydroxyanthranilic acid,one of L-tryptophan metabolites,inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells显示文摘 | Pae HO Oh GS Lee BS | 2006 | Atherosclerosis2006，187，2： | 1 |
| 11 | Antiproliferative effects of alkaloids from Sedum sarmentosum on murine and human hepatoma celll ines显示文摘 | Kang TH Pae HO Yoo JC | 2000 | Ethnopharmacology2000，，70： | 1 |
| 12 | Heme oxygenase-1:its therapeutic roles in inflammatory diseases显示文摘 | Pae HO Chung HT | | 0，，01： | 1 |
| 13 | Role of heine oxygenasel in vascu- lar disease 显示文摘 | Chung HT Pae HO Cha YN | 2008 | Curt Pharrn Des2008，14，5： | 1 |
| 14 | Curcumin inducespro -apoptotic endoplasmic reticulum stress in humanleukemia HL-60 cells显示文摘 | Pae HO Jeong SO Jeong GS | 2007 | Biochem Biophys Res Commun2007，353，4： | 1 |
| 15 | Effects of oral administration of Phellinus linteus on the production of Thl and Th2 type cytokines in mice 显示文摘 | OH GS LEE MS PAE HO | 2006 | Immunopharmacol Immunotoxicol2006，28，2： | 1 |
| 16 | Carbon monoxide in- duces heme oxygenase-1 via activation of protein kinase R- like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress 显示文摘 | Kim KM Pae HO Zheng M | 2007 | Circ Res2007，101，9： | 1 |
| 17 | In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-Dglucose on human hepatocellular carcinoma cell line,SK-HEP-1 cells显示文摘 | OH GS PAE HO OH H | 2001 | Canc- er Lett2001，174，1： | 1 |
| 18 | Roles of heme oxygenase 1 in curcumin-induced growth inhibitionin rat smooth muscle cells显示文摘 | Pae HO Jeong GS Jeong SO | | 0，，03： | 1 |
| 19 | Role of heme oxygenase-1 in vascular disease显示文摘 | Chung HT Pae HO Cha YN | 2008 | Curr Pharm Des2008，14，5： | 1 |
| 20 | Induction of granμlocytic differentiation in acute promyelocytic leukemia cells (HL-60) by water-soluble chitosan oligomer显示文摘 | Pae HO Seo WG Kim NY | 2001 | Leuk Res2001，25，： | 1 |
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