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| 1 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 2 | Increased incidence of and microbiologic changes in pyogenic liver abscesses in the Mexican population显示文摘BACKGROUND Pyogenic liver abscess(PLA)is a rare disease with an estimated incidence that varies widely across the globe,being as high as 115.4/100000 habitants in Taiwan and as low as 1.1-1.2/100000 habitants in Europe and Canada.Even though there are multiple microorganisms capable of producing an abscess in the liver,including Entamoeba histolytica,fungi,and viruses,most abscesses are derived from bacterial infections.The epidemiology of PLA in Mexico is currently unknown.AIM To describe the clinical,demographic and microbiologic characteristics of PLA in Mexico.METHODS This is a retrospective study carried out in two centers,and included patients seen between 2006 and 2018 with the diagnosis of pyogenic abscess.We collected demographic,clinical,and microbiological information,treatment,complications,and outcomes.A logistic regression analysis was used to determine the association between different variables and mortality rates.RESULTS A total of 345 patients were included in this study.233(67.5%)had confirmed PLA,133(30%)patients had no positive culture and negative serology and 9(2.5%)had mixed abscesses.The mean age was 50 years(ranging from 16-97 years)and 63%were female.65%of the patients had positive cultures for Extended Spectrum Beta-Lactamases(ESBL)-Escherichia coli and Klebsiella pneumoniae.Cefotaxime was administered in 60%of cases.The most common sources of infection were ascending cholangitis and cholecystitis in 34(10%)and 31(9%),respectively.The median length of hospital stay was 14 d.165 patients underwent percutaneous catheter drainage.The inpatient mortality rate was 63%.Immunocompromised state[OR 3.9,95%CI:1.42-10.46],ESBL-Escherichia coli[OR 6.7,95%CI:2.7-16.2]and Klebsiella pneumoniae[OR 4-8,95%CI:1.6-14.4]predicted inpatient mortality by multivariate analysis.CONCLUSION The prevalence of PLA is increasing in Mexico and has a very high mortality rate.ESBL-Escherichia coli and Klebsiella pneumoniae are the most common microorganisms causing PLA and are independent predictors of inpatient mortality. | Juanita Pérez-Escobar Wagner Ramirez-Quesada Daniel Alejandro Calle-Rodas Luis Alberto Chi-Cervera Nalu Navarro-Alvarez Jorge Aquino-Matus Juan Pablo Ramírez-Hinojosa Carlos Moctezuma-Velázquez Aldo Torre | 2020 | World Journal of Hepatology2020，12，10： | 5 |
| 3 | Can testosterone therapy be offered to men on active surveillance for prostate cancer? Preliminary results显示文摘这份报告在活跃监视上在 T 缺乏的人的一个队与 T 治疗介绍我们的经验(作为) 为 Gleason 3 + 3 并且 Gleason 3 + 4 前列腺癌症(PCa ) 。回顾的图表评论与 T 缺乏识别了 28 个人经历 T 治疗(T 组) 至少 6 个月了当时在上至于 PCa。96 个人在上的一个比较组至于有未经治疗的 T 缺乏的 PCa (别组织) 在一样的机构被识别。同样协议跟随了修改爱泼斯坦标准和有小量的 Gleason 3 + 的一个单个核心的人的允许的包括 4 PCa。吝啬的年龄是 59.5 和 61.3 年,并且意味着后续是为 T 的 38.9 和 42.4 个月并且不分别地组织。在 T 组的所有 28 个人, 3 (10.7%) 人们在格利森分数开发了增加当时在上作为。22,在 T 的人与 Gleason 3 + 组织 3 疾病, 7 (31.8%) 人们包括开发了 Gleason 3 + 的 3 个人(13.6%) 开发了活体检视前进 4 PCa。有 Gleason 3 + 的 6 个人在基线的 4 疾病, 2 (33.3%) 人们在肿瘤体积开发了增加,并且任何一个都没发展在 Gleason 3 + 以外升级 4。所有 96 个人在别组织有的 Gleason 3 + 在基线的 3 疾病并且,(44.7%) 43 开发了活体检视前进,包括有升级到 Gleason 7 的 9 个人(9.38%)(3 + 4 ) 。活体检视前进率为组和历史的控制是类似的。在人在上的活体检视前进作为在 3 年由 T 治疗显得未受影响。在 T 缺乏的人在上的 T 治疗的未来的控制安慰剂的试用作为应该被认为给对待的人经验丰富的征兆的好处。 | Ravi Kacker Mariam Hult Ignacio F San Francisco William P Conners Pablo A Rojas William C Dewolf Abraham Morgentaler | 2016 | Asian Journal of Andrology2016，18，1： | 2 |
| 4 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 5 | Rapid determination of particle velocity from space-time images using the Radon transform 显示文摘 | Drew P J Pablo B Gert C | 2010 | Journal of Computational Neuro- science2010，29，1： | 1 |
| 6 | Age-related changes in the avian primary lymphoid organs (thymus and bursa of Fabricius)显示文摘 | Emilia C Pablo P P Belen D | 2003 | Mierosc Res Techniq2003，62，： | 1 |
| 7 | 'Grain mumber and its relationship with dry matter, N and P in the spikes at heading in response to N × P fertilization in barly显示文摘 | Pablo P Roxana S Gustavo A S | 2004 | Field Crops Research2004，90，： | 1 |
| 8 | Western and Eastern Views on Social Net- works 显示文摘 | Pablos P O D | 2005 | The Learning Organisation2005，，5： | 1 |
| 9 | Multifractal analysis of ground-level ozone concentrations at urban, suburban and rural background monitoring sites in Southwestern Iberian Peninsula显示文摘 | Pablo P D Francisco J J H Eduardo G de R | 2013 | Atmospheric Pollution Research2013，4，2： | 1 |
| 10 | Increased fibrin polymerization rate in patients with primary antiphospholipid syndrome and systemic lupus erythematosus显示文摘 | De Pablo P Ramirez A Cortina E | 2003 | Clin Appl Thrombo Hemost2003，9，3： | 1 |
| 11 | Post traumatic partial seizures显示文摘 | Carvajal P Almarcegui C Pablo MJ | 2001 | Rev Neurol2001，33，8： | 1 |
| 12 | Determinants of initial satisfaction with the succession process in family firms:A conceptual model显示文摘 | Sharma P Chrisman J J Pablo A and Chua J H | 2001 | Entrepreneurship Theory & Practice2001，25，3： | 1 |
| 13 | Distribution and abundance of microsatellites in the genome of bivalves显示文摘 | Fernando Cruz Montse Pérez Pablo Presa | 2004 | Gene2004，，： | 1 |
| 14 | Periodontitis in sys- temic rheumatic diseases显示文摘 | de Pablo P Chappie IL Buckley CD | 2009 | Nat Rev Rheumatol2009，5，4： | 1 |
| 15 | Western and eastern views on so- cial networks 显示文摘 | Ordenez de Pablos P | 2005 | Learning Organisation2005，12，5： | 1 |
| 16 | Human resource management systems and their role in the development of strategic resources: empirical evidence 显示文摘 | Ord6fiez de Pablos P | 2004 | Journal of European Industrial Training2004，28，6： | 1 |
| 17 | Global lithium resources : relative importanceof pegmatite,brine and other deposits 显示文摘 | Stephen E Kealer Paul W Gruber Pablo A Medina Gregory A Keoleian Mark P Everson Timothy J Wall-ington | 2012 | Ore GeologyReviews2012，48，： | 1 |
| 18 | Determinants of Initial Satisfaction with the Succession Process in Family Firms: A Conceptual Model显示文摘 | SHARMA P CHRISMAN J J PABLO A | 2001 | Entrepreneurship Theory and Practice2001，25，3： | 1 |
| 19 | Effect of damaged starch levels on flour-thermal behaviour and bread staling显示文摘 | Alberto E. León Gabriela N. Barrera Gabriela T. Pérez Pablo D. Ribotta Cristina M. Rosell | 2006 | European Food Research and Technology2006，，2： | 1 |
| 20 | Periodontitis in systemic rheumatic diseases显示文摘 | de Pablo P Chapple IL Buckley CD | 2009 | Nat Rev Rheumatol2009，5，4： | 1 |
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