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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Particle segregation in fluidized binary mixtures显示文摘 | Hoffmann A C Janssen M L P B J Prins | 1993 | Chem Eng Sci1993，48，9： | 1 |
| 3 | Genes prefereutially induced by depolarization after con-cussive brain injury: effects of age and injury sever- ity显示文摘 | GIZA C C PRINS M L HOVDA D A | 2002 | J Neurotrauma2002，19，4： | 1 |
| 4 | The tomato gene Sw-5 is a member of the coiled coil,nucle- otide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco 显示文摘 | Spassova M L Prins T W Folkertsma R T | 2001 | Mol Breed2001，7，2： | 1 |
| 5 | Ocean circulation and iceberg discharge in the glacial North Atlantic:inferences from unmixing of sediment distributions显示文摘 | PRINS M A BOUWER L M BEETS C J | 2002 | Journal of Geology2002，30，： | 1 |
| 6 | Genome-wide Association Study Identifies Candidate Genes for Male Fertility Traits in Humans显示文摘 | Gülüm Kosova Nicole M. Scott Craig Niederberger Gail S. Prins Carole Ober | 2012 | The American Journal of Human Genetics2012，，6： | 1 |
| 7 | Potential global fire monitoring from EOS-MODIS显示文摘 | Kaufman Y J Justice C O Flynn L P Kendall J D Prins E M Giglio L Ward D E Menzel W P & Setzer A W | 1998 | Journal of Geophysical Research1998，103，32： | 1 |
| 8 | Sex and the course of HIVinfection in the pre- and highly active antiretroviral ther-apy eras 显示文摘 | Prins M Meyer L Hessol NA | 2005 | AIDS2005，19，4： | 1 |
| 9 | Applying the Job Demands-resources Model to the Work-home Interface: A Study among Medical Residents and Their Partners 显示文摘 | Bakker A B ten Brummelhuis L L Prins J T van der Heijden F M M A | 2011 | Journal of Vocational Behavior2011，，79： | 1 |
| 10 | Characterization of RNA mediated resistance to tomato spotted wilt virus in transgenic tobacco plants显示文摘 | DE HAAN P GIELEN J J L PRINS M | 1992 | Bio/Technology1992，10，： | 1 |
| 11 | Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability显示文摘 | Prins M L Alexander D Giza C C | 2013 | J Neuro- trauma2013，30，1： | 1 |
| 12 | Release of tumor necrosis factor alpha and interleukin 6 during antibioctics killing of Escherichia coli in whole blood:influence of antibiotic class,antibiotic concentration,and presence of septic serum显示文摘 | PRINS J M KUIJPER E D J MEVISSEN M L C | 1995 | Infect Immun1995，63，6： | 1 |
| 13 | β-adrenergic activation and memory for emotional events显示文摘 | Cahill L Prins B Weber M | 1994 | Nature1994，371，6499： | 1 |
| 14 | Functional study of a monoclonal antibody to IgE Fc receptor (FceR2) of eosinophils, platelets and macrophages显示文摘 | Capron M Jouault T Prin L | 1986 | J Exp Med1986，164，1： | 1 |
| 15 | Ocean circulation and iceberg discharge in the glacial North Atlantic: inferences from unmixing of sediment size distributions 显示文摘 | Prins M A Bouwer L M Beets C J | 2002 | Journal of Geology2002，30，： | 1 |
| 16 | Ocean circulation and iceberg discharge in the glacial North Atlantic:inferences from unmixing of sediment distributions显示文摘 | Prins M A Bouwer L M Beets C J | 2002 | Journal of Geology2002，30，： | 1 |
| 17 | Patient-reported treatment satisfaction with oral rivaroxaban versus standard therapy in the treatment of acute symptomatic deep-vein thrombosis显示文摘 | BAMBER L WANG M Y PRINS M H | 2013 | Thromb Haemost2013，110，4： | 1 |
| 18 | Fast N-body simulation with CUDA显示文摘 | Nyland L Harris M Prins J | 2007 | GPU Germs2007，3，： | 1 |
| 19 | Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T- cell responses modulated by the local central nervous system tumor micrcenvironment显示文摘 | LIAU L M PRINS R M KIERTSCHER S M | 2005 | Clinical Cancer Research2005，11，： | 1 |
| 20 | Mechanistic explanation of the formation of high quality MCM-41 with high hydrothermal stability显示文摘 | LUECHINGER M FRUNZ L PIRNGRUBER G D PRINS R | 2003 | Microporous and Mesoporous Materials2003，64，123： | 1 |
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