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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Depot-related gene expression in human subcutaneous and omental adipocytes显示文摘 | Montague CT Prins JB Sanders L | 1998 | Diabetes1998，47，9： | 1 |
| 3 | Tracking rodent - dispersed large seeds with passive integrated transponder ( PIT ) tags 显示文摘 | Suselbeek L Jansen P A Prins H H T | 2013 | Methods in Ecology and Evolution2013，4，6： | 1 |
| 4 | MAS NMR, TPR and TEM studies of the interaction of NiMo with alumina and silica-alumina supports显示文摘 | QU L ZHANG W KOOYMAN P J PRINS R | 2003 | J Catal2003，215，1： | 1 |
| 5 | Particle segregation in fluidized binary mixtures显示文摘 | Hoffmann A C Janssen M L P B J Prins | 1993 | Chem Eng Sci1993，48，9： | 1 |
| 6 | Autogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis显示文摘 | Prin L Lefebre P Gruart V | 1997 | Bone Marrow Transplant1997，19，10： | 1 |
| 7 | MAS NMR, TPR, and TEM studies of the interaction of NiMo with alumina and silica-alumina supports显示文摘 | QU L ZHANG W KOOYMAN P J PRINS R | 2003 | J Catal2003，215，1： | 1 |
| 8 | Calphad显示文摘 | Prins S N Cornish L A Stumpf W E | 2003 | 27(1):792003，27，1： | 1 |
| 9 | Fat as an endocrine organ:relationship to the metabolic syndrome 显示文摘 | Hutley L Prins JB | 2005 | Am J Med Sci2005，330，6： | 1 |
| 10 | Genes prefereutially induced by depolarization after con-cussive brain injury: effects of age and injury sever- ity显示文摘 | GIZA C C PRINS M L HOVDA D A | 2002 | J Neurotrauma2002，19，4： | 1 |
| 11 | The tomato gene Sw-5 is a member of the coiled coil,nucle- otide binding,leucine-rich repeat class of plant resistance genes and confers resistance to TSWV in tobacco 显示文摘 | Spassova M L Prins T W Folkertsma R T | 2001 | Mol Breed2001，7，2： | 1 |
| 12 | Validation of the fibro test biochemical markers score in assessing liver fibrosis in hepatitis C patients 显示文摘 | Rose E Adams L Prins A | 2003 | Clin Chem2003，49，： | 1 |
| 13 | Patient-reported treatment satisfaction with oral rivaroxaban versus standard therapy in the treatment of acute symptomatic deep-vein thrombosis 显示文摘 | Bamber L Wang MY Prins MH | 2013 | Thromb Haemost2013，110，4： | 1 |
| 14 | Depot-and sexspeeioc difter- ences in human leptin mRNA expression:implieations for the control of regional fat distribution 显示文摘 | Montague CT Prins JB Sanders L | 1997 | Diabetes1997，46，3： | 1 |
| 15 | Structure of oxidic NiMo/SiO2 hydrotreating cat- alyst precursors显示文摘 | Medici L Prins R | 1996 | Journal of Catalysis1996，163，1： | 1 |
| 16 | Ocean circulation and iceberg discharge in the glacial North Atlantic:inferences from unmixing of sediment distributions显示文摘 | PRINS M A BOUWER L M BEETS C J | 2002 | Journal of Geology2002，30，： | 1 |
| 17 | Fat as endocrine organ:relationship to the metabolic syndrome显示文摘 | PRINS JB | 2005 | Med Sci2005，330，6： | 1 |
| 18 | Anonymous fingerprinting with robust QIM watermarking techniques显示文摘 | Prins J P Erkin Z Lagend R L | 2007 | EURASIP Journal on Information Security2007，8，： | 1 |
| 19 | Validation of the Fibro Test biochemical markers score in assessing liver fibrosis in hepatitis C patients显示文摘 | Adams L Prins A | 2003 | Clim chem2003，49，3： | 1 |
| 20 | GenEST, a powerful bidirectional link between cDNA sequence data and gene expression profiles generated by cDNA-AFLP显示文摘 | Qin L Prins P Jones J T | 2001 | Nucleic Acids Research2001，29，7： | 1 |
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